Anterior-Chamber Angle and Axial Length Measurements in Normal Chinese Children

Jin, Peiyao; Li, Meili; He, Xiangui; Lu, Lina; Zhu, Jianfeng; Chang, Ta Chen; Zou, Haidong

doi:10.1097/ijg.0000000000000404

Cited by 23 publications

(24 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We reanalyzed the swept-source ASOCT data (SS-1000 CASIA TM , TOMEY, Nagoya, Japan) obtained from 43 children that were taken in the dark room condition without pupil dilation. [12] Vertical scan images in ASOCT were often disturbed by the eyelids; thus, we selected the clearest horizontal scan images. The ASOCT parameters were evaluated by Y.N.…”

Section: Methodsmentioning

confidence: 99%

“…[11] However Jin P et al first reported an increase in IT in parallel with the increasing age of children (7–15 years). [12] The association between IT changes and age or other ocular parameters has not been investigated. Therefore, our study aimed to investigate the IT in children and determine the association between IT and ocular parameters, especially in those children who were also in developing period, thus, this study may lead to an understanding of ocular structural development.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Nakakura¹,

Nagata²,

Shimizu³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

Purpose The uvea comprises the iris, ciliary body, and choroid. However, the development of the anterior part (iris and ciliary body) in children is not yet fully elucidated. We investigated the iris thickness (IT) in children using swept-source anterior-segment optical coherence tomography (ASOCT). Methods In this retrospective, clinic-based study, we enrolled 41 children (mean ± standard deviation: 6.8 ± 3.3 years; range: 3–16; 17 males) with normal or mild refractive error. Horizontal scanning images of swept-source ASOCT were analyzed in temporal and nasal angle areas. The ITs at 1 and 2 mm from the pupil edge were measured using swept-source ASOCT. The association between IT and age, sex, and ocular morphological parameters (i.e., axial length, average corneal curvature, central corneal thickness, inter-scleral spur distance, and anterior chamber depth) was assessed using Pearson’s correlation coefficient (r) and linear regression analysis. Results The average IT (temporal and nasal) at 1 and 2 mm were 0.432 ± 0.060 (0.302−0.569 mm) and 0.337 ± 0.045 (0.229−0.414 mm), respectively. There was a significant correlation between age and average IT ( r = 0.45, P = 0.002 at 1 mm and r = 0.31, P = 0.042 at 2 mm). Multiple linear regression analysis revealed that age (coefficient: 0.01), axial length (−0.02), average corneal curvature (0.01), and anterior chamber depth (0.01) at 1 mm as well as age (0.00), average corneal curvature (0.09), anterior chamber depth (0.06), and male (–0.02) at 2 mm were identified as predictors of IT. Conclusions IT in children increases with age. Additionally, IT was thinner with longer axial length and in males, thicker in eyes with deeper anterior chamber and flatter corneal curvature. Our study may partly explain the development of eyeball structures in children.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Nakakura¹,

Nagata²,

Shimizu³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…), and only a few such studies have sought to assess the angle in children (Urbak ; Jin et al. ; Fernández‐Vigo et al. ; Tandon et al.…”

Section: Introductionmentioning

confidence: 99%

“…To date most of these angle studies, especially the larger ones, have been performed in adult Asian populations (Usui et al 2011;Shi et al 2012;Hong et al 2013), and only a few such studies have sought to assess the angle in children (Urbak 1999;Jin et al 2016;Fern andez-Vigo et al 2017;Tandon et al 2017). This lack of literature data also means that the possible effects of several factors such as gender, age, refractive error, angle or TM measurements on the size of the anterior chamber angle and its structures have yet to be addressed.…”

Section: Introductionmentioning

confidence: 99%

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Fernández‐Vigo

Kudsieh²,

De‐Pablo‐Gómez‐de‐Liaño

et al. 2018

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose To measure the Schlemm's canal (SC) in vivo by Fourier‐domain optical coherence tomography (FD‐OCT) in a Caucasian paediatric population. Methods Participants of this cross‐sectional study were 290 healthy children. In the right eye of each child, SC cross‐sectional diameter and area measurements were made with the FD‐OCT instrument RTVue® (Optovue Inc, Fremont, CA, USA) in the nasal and temporal quadrants. These SC variables were then assessed for correlation with the factors age, gender, refractive error, anterior chamber angle and trabecular meshwork (TM) metrics. Finally, the reproducibility of the SC measurements was assessed in 30 of the participants. Results Mean participant age was 10.7 ± 3.4 years (range 3–18). SC diameters could be measured in both quadrants in 70.6% and 70.4% of subjects, respectively. Mean SC diameters were similar (p = 0.125) for the temporal and nasal quadrants: 266.7 ± 84.1 μm (range 131–509) and 273.2 ± 77.3 μm (range 124–486), respectively. Mean SC areas were also similar (p = 0.167) for the two quadrants: 9975 ± 3514 μm2 (range 4000–23 000) versus 9688 ± 3297 μm2 (range 3000–24 000). No differences were detected in SC measurements according to gender, refractive error or angle and TM measurements (R ≤ 0.116; p ≥ 0.125). The exception was age which was directly correlated with SC size (p ≤ 0.041). The reproducibility of the SC measurements was excellent (intraclass correlation coefficients ≥0.936). Conclusion FD‐OCT allows the identification of the SC in children. Our data indicate an increase in SC size produced with age.

show abstract

“…The results of this study showed that inter-gender differences in AC indices in patients with Down syndrome have a pattern similar to normal individuals, and females have shallower AC compared to males; this difference is independent of age. [ 20 22 25 26 ] In addition, the ACA gender difference was only observed in the temporal quadrant, and there were no inter-gender differences in the other three meridians. In a study by Aslan,[ 17 ] the correlation of AC indices to gender was not evaluated but Haugen et al .…”

Section: Discussionmentioning

confidence: 88%

Anterior chamber dimensions, angles and pupil diameter in patients with Down syndrome: A comparative population-based study

Asgari

Hashemi

Fotouhi

et al. 2020

Indian J Ophthalmol

View full text Add to dashboard Cite

Purpose: To study the anterior chamber (AC) dimensions, angles and pupil diameter (PD) in patients with Down syndrome compared to normal controls. Methods: Prospective study is comparing the AC parameters in patients with Down syndrome aged 10-30 years and age-matched controls. Extracted indices included average anterior chamber depth on the 2-mm ring (ACD-2 mm), 4-mm ring (ACD-4 mm), at the corneal apex from the endothelium (endo-ACD), at the corneal apex from the epithelium (epi-ACD), anterior chamber volume (ACV), mean anterior chamber angle (ACA), and PD measured by Pentacam. Results: Data from 202 patients with Down syndrome (age 17.2 ± 4.8 years) were compared with 190 normal controls (age 17.2 ± 4.5 years). In Down and normal groups, mean ± SD were 2.51 ± 0.31 and 2.83 ± 0.34 mm for ACD-2 mm, 1.65 ± 0.30 and 1.93 ± 0.31 mm for ACD-4 mm, and 3.03 ± 0.29 and 3.24 ± 0.26 mm for endo-ACD, 3.54 ± 0.29 and 3.80 ± 0.26 mm for epi-ACD, mean 169.31 ± 30.38 and 200.17 ± 33.20 mm 3 for ACV, 40.69 ± 4.50 and 39.97 ± 4.12° for ACA, and 2.79 ± 0.62 and 3.59 ± 0.80 mm for PD, respectively (all P < 0.001). None of the studied indices significantly correlated with age, except for ACA ( P = 0.011). All parameters, except for PD, were significantly higher in males compared to females (all P < 0.001). Temporal ACA was significantly wider in male subjects (44.61 ± 6.52 vs. 42.24 ± 6.52°; P < 0.001). Conclusion: The AC in patients with Down syndrome is smaller than normal individuals. AC in females with Down syndrome is smaller than males, and the narrower ACA is attributable to the difference in the temporal angle and not the ACA in other meridians.

show abstract

Anterior-Chamber Angle and Axial Length Measurements in Normal Chinese Children

Abstract: All angle measurements increased with age and were positively correlated with the ACD in children 7 to 15 years of age. The AL increased logarithmically with age.

Cited by 23 publications

References 22 publications

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Determination of iris thickness development in children using swept-source anterior-segment optical coherence tomography

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Anterior chamber dimensions, angles and pupil diameter in patients with Down syndrome: A comparative population-based study

Contact Info

Product

Resources

About