Antenna-type radiofrequency generator in nanoparticle-mediated hyperthermia

Nasseri, Behzad; Yilmaz, Mehmet; Türk, Mustafa; Kocum, Ismail Cengiz; Pi̇şki̇n, Erhan

doi:10.1039/c6ra03197h

Cited by 13 publications

(16 citation statements)

References 28 publications

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“…Heat generating by using RF wave in the presence of metallic nanoparticles was studied in our previous work [11]. RF (144.00015 MHz, 180 W) exposed to the nanoparticles revealed that the highest heat rate records in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In the RF hyperthermia, the external energy is in the form of RF waves around megahertz (MHz) domain. Despite the advantages such as less harmfulness, high-tech level and costeffectiveness, some other factors should be considered including the wave focusing on target, the SAR index as well as the penetration depth [8] should be considered as a potential disadvantageous [9][10][11]. The other notable factors that can be marked are nanoparticles morphology and the efficient RF wavelength that needed to provide the activation energy [12].…”

Section: Introductionmentioning

confidence: 99%

“…The implication of energy diffusion and the damageable effect of RF induced nanoparticles on the morphology of tissue was considered as a challengeable area in many research articles [23]. The gold‐iron oxide (core‐shell) nanoparticles in our previous study presented significant advantages in case of malignant cells disruption compared to other nanoparticles as well [11].…”

Section: Introductionmentioning

confidence: 99%

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Penetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observations

Nasseri

Kocum

Seymen

et al. 2019

IET nanobiotechnol.

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In present study, the effective penetration of radiofrequency (RF) induced gold decorated iron oxide nanoparticles (GS@IONPs) hyperthermia was investigated. The effective penetration depth of RF also the damage potency of hyperthermia was evaluated during histopathology observations which were done on the chicken breast tissue and hepatocellular carcinoma (HCC) models. The thermal damages are well-documented in our previous cellular study which was engaged with potency of RF hyperthermia in Epithelial adenocarcinoma (MCF-7) and fibroblast (L-929) cells deaths [1]. In recent work, PEGylated iron oxide nanoparticles (IONPs) were used as base platform for gold magnetic nanoparticles (GS@IONPs) formation. The 144.00015 MHz, 180W RF generator was applied for stimulating the nanoparticles. The chicken breast tissue and the hepatocellular tumor model was considered in the experimental section. In histology studies, the structural changes also the effective penetration depth of RF induced nanoparticles was observed through microscopic monitoring of the tissue slices in histology observations (Gazi medical school). The highest damage level was seen in 8.0 µm tissue slices where lower damages were seen in depth of 1.0 cm and more inside tissue. The histology observations clarified the effective penetration depth of RF waves and irreversible damages in the 2.0 cm inside the tissue.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Penetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observations

Nasseri

Kocum

Seymen

et al. 2019

IET nanobiotechnol.

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“…Similarly, AuNPs were prepared according to the well-known citrate-reduction method with some modifications, which was shown in our earlier reports [34][35][36][37][38][39]. Briefly, the proper amount of aqueous solution of HAuCl 4 (50 mL, 1 mM) in a three-neck round bottom flask was heated to boiling under vigorous magnetic stirring.…”

Section: Synthesis Of Agnps and Aunpsmentioning

confidence: 99%

Metallic Nanoparticle-Decorated Polydopamine Thin Films and Their Cell Proliferation Characteristics

2020

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Plasmonic metal nanoparticle (NP)-decorated thin films of biobased and biocompatible polymers provide significant opportunities in various biomedical applications. Inspired from the adhesive proteins of the marine mussels, polydopamine (PDA) serves as a versatile, biocompatible, and simple thin-film material and enhances cell growth and proliferation. Herein, we report the fabrication of the gold NPs (AuNPs) or silver NPs (AgNPs)-deposited thin films of PDA and their employment in cell growth and proliferation. PDA thin film with its numerous functional groups enabled well-controlled adsorption of NPs. The number density of NPs was manipulated simply by tuning the deposition time. Cell viability test for human lung cancer (A549) and human colon cancer (CaCO2) cell lines indicated that a thin layer of PDA film remarkably enhanced the cell growth and proliferation. The lower number density of NPs for the 24 h of the culture time resulted in a higher proliferation rate. However, the increase in both the number density of NPs and culture time led to a decrease in cell growth.

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“…In recent years, the research work involving nanoparticles in cancer treatment has been actively conducted in a wide range of areas, such as drug-delivery, 3,4 imaging contrast agents 5,6 and hyperthermia agents. [7][8][9][10][11][12] These methods are designed to enhance the specificity, in the meantime without introducing negative side effects.…”

Section: Introductionmentioning

confidence: 99%

Laser heating of metallic nanoparticles for photothermal ablation applications

Liu

Shan

et al. 2017

AIP Advances

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In order to search for a suitable frequency and material with higher photothermal efficacy for hyperthermia application in cancer treatment, a comparative study on laser heating of Au/Ag nanoparticles and Ag nanowires has been conducted. It is found that gold nanoparticles are more photothermal efficient in comparison with silver nanoparticles and silver nanowires at 450nm and 532 nm. Gold nanoparticles are more heated by 532 nm laser than 450 nm laser. In contrast, silver nanoparticles show slightly less temperature rise at 532 nm than 450 nm laser. For silver nanowires, no significant photothermal effect has been observed. Size-dependent effect study indicates that the absorption efficiency of single gold nanoparticles of larger diameter is higher than that of smaller diameter, in the diameter range of 0-50nm. A mathematical model for describing the heating profile in the heating sample has been built. The mathematical model can be utilized to predict the optimal treatment size of tumor.

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Antenna-type radiofrequency generator in nanoparticle-mediated hyperthermia

Abstract: This study covers the employment an antenna-type RF generator modulus at varying powers for different nanoparticle types to evaluate viability, apoptosis and necrosis of L-929 fibroblast and MCF-7 breast cancer cell lines.

Cited by 13 publications

References 28 publications

Penetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observations

Penetration Depth in Nanoparticles Incorporated Radiofrequency Hyperthermia into the Tissue: Comprehensive Study with Histology and Pathology Observations

Metallic Nanoparticle-Decorated Polydopamine Thin Films and Their Cell Proliferation Characteristics

Laser heating of metallic nanoparticles for photothermal ablation applications

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