Antenna Applicators for Medical Microwave Radiometers

Sedankin, M. K.; Leushin, V. Yu.; Гудков, А. Г.; Vesnin, Sergey; Сидоров, И. А.; Agasieva, S. V.; Ovchinnikov, Lev; Ветрова, Н. А.

doi:10.1007/s10527-018-9820-1

Cited by 18 publications

(10 citation statements)

References 4 publications

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“…A number of devices called radiometers are functioning in this range. These devices allow one to monitor the functional state of a human body in the event of pathologies 9 , to register the microwave radiation upon excitation of aqueous and protein media 10 , and also to monitor the functional activity of protein systems by registering changes in the brightness temperature 11,12 . The level of background radiation within a typical radiometer bandwidth (~0.1 GHz) at a temperature of 310 К makes up 4 × 10 −13 W 13 , while pathologies in human body are accompanied by radiation in the same frequency range at a level corresponding to a change in the brightness temperature of the order of 0.4 °С 13 .…”

mentioning

confidence: 99%

AFM Imaging of Protein Aggregation in Studying the Impact of Knotted Electromagnetic Field on A Peroxidase

Ivanov

Pleshakova

Shumov

et al. 2020

Sci Rep

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The phenomenon of knotted electromagnetic field (KEMF) is now actively studied, as such fields are characterized by a nontrivial topology. The research in this field is mainly aimed at technical applications-for instance, the development of efficient communication systems. Until present, however, the influence of KEMF on biological objects (including enzyme systems) was not considered. Herein, we have studied the influence of KEMF on the aggregation and enzymatic activity of a protein with the example of horseradish peroxidase (HRP). The test HRP solution was irradiated in KEMF (the radiation power density was 10 −12 W/cm 2 at 2.3 GHz frequency) for 40 min. After the irradiation, the aggregation of HRP was examined by atomic force microscopy (AFM) at the single-molecule level. The enzymatic activity was monitored by conventional spectrophotometry. It has been demonstrated that an increased aggregation of HRP, adsorbed on the AFM substrate surface, was observed after irradiation of the protein sample in KEMF with low (10 −12 W/cm 2) radiation power density; at the same time, the enzymatic activity remained unchanged. the results obtained herein can be used in the development of models describing the interaction of enzymes with electromagnetic field. The obtained data can also be of importance considering possible pathological factors that can take place upon the influence of KEMF on biological objects-for instance, changes in hemodynamics due to increased protein aggregation are possible; the functionality of protein complexes can also be affected by aggregation of their protein subunits. These effects should also be taken into account in the development of novel highly sensitive systems for human serological diagnostics of breast cancer, prostate cancer, brain cancer and other oncological pathologies, and for diagnostics of diseases in animals, and crops. It is known that electromagnetic radiation of various intensity can have different influence on human body. Electromagnetic fields can have various topology, such as transverse and knotted one (knotted electromagnetic field, KEMF) 1,2. The simplest and most common electromagnetic waves are transverse ones, and, to date, their effects have been widely studied in various frequency and intensity ranges. As regards biomedical applications, microwave radiation is interesting in that, depending on its intensity, it is employed in biological research, and in both medical diagnostics and therapy. In this way, upon exposure of biological tissues to high-intensity radiation (~90 W/cm 2), their temperature increases to ~90 °С, and denaturation of biological objects is observed. It was shown that, under such conditions, partial loss of functional activity of proteins (for instance, peroxidase) is observed 3. At lower radiation intensity (10 μW/cm 2 4), both positive therapeutic effects (which usually take place owing to local heating 5) and negative effects are observed. Here, it should be noted that studies on the application of non-thermal effects of low-power microwave r...

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mentioning

confidence: 99%

AFM Imaging of Protein Aggregation in Studying the Impact of Knotted Electromagnetic Field on A Peroxidase

Ivanov

Pleshakova

Shumov

et al. 2020

Sci Rep

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“…4(a)), E is an electric field vector. Values T EMI and T REC characterize electromagnetic interference when measured with a radiometer [17,19]. The coefficient S 11 determines the interaction between the antenna and the biological tissue.…”

Section: Modeling Of the Radiation Field And Numerical Modelmentioning

confidence: 99%

“…The emergence printed antennas for microwave radiothermometry (see [17]) improve the efficiency of diagnosis based on an analysis of the internal temperature of the breast. Switching to textile antennas, that are embedded in clothing and are able to conduct continuous monitoring can make revolutionary advances in breast oncology practice.…”

Section: Modeling Of the Radiation Field And Numerical Modelmentioning

confidence: 99%

“…As mentioned above, this is due to the complexity of creating measuring equipment and the quality of measurements. Interest in this technique has significantly grown after the creation of effective microwave radiometers [8,17,18]. Note that microwave radiothermometry is applicable not only for the diagnosis of breast cancer, but also for the diagnosis of other diseases [19].…”

Section: Introductionmentioning

confidence: 99%

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Creativity in Intelligent Technologies and Data Science

2019

Communications in Computer and Information Science

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The method of microwave radiometry is one of the areas of medical diagnosis of breast cancer. It is based on analysis of the spatial distribution of internal and surface tissue temperatures, which are measured in the microwave (RTM) and infrared (IR) ranges. Complex mathematical and computer models describing complex physical and biological processes within biotissue increase the efficiency of this method. Physical and biological processes are related to temperature dynamics and microwave electromagnetic radiation. Verification and validation of the numerical model is a key challenge to ensure consistency with medical big data. These data are obtained by medical measurements of patients. We present an original approach to verification and validation of simulation models of physical processes in biological tissues. Our approach is based on deep analysis of medical data and we use machine learning algorithms. We have achieved impressive success for the model of dynamics of thermal processes in a breast with cancer foci. This method allows us to carry out a significant refinement of almost all parameters of the mathematical model in order to achieve the maximum possible adequacy. 1

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“…In [2] the results of modeling of a number of printed antennas are presented, which confirmed the possibility of their use in multichannel radiometers. Currently, the following main types of medical antennas for microwave radiometry are the most widely used: waveguide, printed, vibratory or frame antennas, as well as intracavitary antennas [3][4][5][6]. Unlike waveguide antennas, which have a waveguide segment between the emitter and the antenna aperture, printed antennas have the emitter printed directly on the dielectric substrate.…”

Section: Introductionmentioning

confidence: 99%

Numerical simulation of miniature antennas applicators of microwave radiometry for diagnostics of the functional state of the brain

et al. 2019

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This paper describes the use of Finite Difference Time Domain technique of numerical modeling for development and simulation symmetrical dipole with triangular shoulders placed in a cylindrical housing and a spiral antenna placed in a cylindrical housing for use in microwave radiometry. The new sensors have been tested and validated on different phantoms and biological tissues. Results suggest sufficient characteristics of broadband antennas for potential use in brain functional diagnostics.

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Antenna Applicators for Medical Microwave Radiometers

Cited by 18 publications

References 4 publications

AFM Imaging of Protein Aggregation in Studying the Impact of Knotted Electromagnetic Field on A Peroxidase

AFM Imaging of Protein Aggregation in Studying the Impact of Knotted Electromagnetic Field on A Peroxidase

Creativity in Intelligent Technologies and Data Science

Numerical simulation of miniature antennas applicators of microwave radiometry for diagnostics of the functional state of the brain

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