Antenatal sonographic diagnosis of clubfoot: A six-year experience

Pagnotta, Gaetano; Maffulli, Nicola; Aureli, Stefano; Maggi, Elisa; Mariani, Massimo; Yip, Kay‐Pong

doi:10.1016/s1067-2516(96)80015-9

Cited by 41 publications

(25 citation statements)

References 16 publications

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“…The findings of the present study correlated with those of Lee k et al, [15], Pagnotta G et al, [16] and Khronf N et al, [17]. Our values were higher as compared to those of the other studies.…”

Section: Discussionsupporting

confidence: 91%

Frequency of Foetal Anomalies in a Tertiary Care Centre

Babu

Pasula²

2013

JCDR

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Objective: The present study was undertaken to explore the incidence of congenital foetal anomalies and the advantages of ultrasonography in detecting the foetal anomalies during the antenatal period. Method:We focused our study on 1000 consecutive pregnancies that came for check up in the second and third trimesters, with major or minor clinically relevant malformations which were detectable by ultrasonography. Results:The analysis revealed that they were 38 foetal anomalies in 37 foetuses. One had multiple anomalies, with the highest incidence of neural tube defects. There was also significant correlation with consanguinity. Conclusion:The overall incidence of congenital foetal anomalies in the present study was 3.8%.This might be probably due to environmental pollution, radiation, exposure to different chemicals and teratogenic drugs.

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Section: Discussionsupporting

confidence: 91%

Frequency of Foetal Anomalies in a Tertiary Care Centre

Babu

Pasula²

2013

JCDR

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“…Historically, our ability to properly predict a clubfoot has been poor, with the literature reporting positive US with normal feet varying between 0 and 40% [2,3,4,5,6,7,8,9]. We have found similar diagnostic inaccuracy in the current study (31%), as well as in our retrospective analysis (19%) [10].…”

Section: Discussionsupporting

confidence: 77%

“…Several studies have reported on the accuracy of prenatally diagnosed clubfeet [2,5,6,7,8,9], but none have been able to correlate characteristics found on obstetric US to severity at birth. Recently, we described and retrospectively evaluated a novel sonographic severity classification [10].…”

Section: Introductionmentioning

confidence: 99%

Prospective Evaluation of a Prenatal Sonographic Clubfoot Classification System

et al. 2013

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Background: The purpose of this study was to prospectively evaluate our recently described fetal sonographic classification system for prenatal diagnosis of clubfoot. Methods: Over 18 months, we prospectively enrolled consecutive pregnant patients evaluated for a prenatally diagnosed clubfoot. Prenatal sonographic scores assigned by a radiologist were compared to final clinical diagnosis and severity given by a pediatric orthopedic surgeon. Pearson's χ² test and logistic regression were used in statistical analyses on the subject level. Generalized estimating equations were used in analyses on the foot level to account for intrasubject correlation. Results: There were 50 subjects, with 26 unilateral and 24 bilateral clubfeet, according to the prenatal ultrasound (US). A total of 51 (69%) of 74 feet and 36 (72%) of 50 subjects had a postnatal diagnosis of clubfoot. The accuracy of diagnosis in cases of a severe, moderate, and mild US score was 94, 70, and 25%, respectively (p = 0.003 comparing moderate-severe vs. mild). US severity correlated with the Dimeglio classification scoring system (Spearman's correlation 0.30). Conclusion: The fetal sonographic scoring system is predictive of clinical severity after birth, and improves the ability to counsel families with a prenatal diagnosis of clubfoot.

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“…Despite not reporting the percentage of postnatal abnormalities associated with isolated clubfoot, the authors suggested that karyotyping should be done in all suspected cases of isolated clubfoot, since not all foetuses with chromosomal aberrations present structural anomalies. Pagnotta et al 32 showed that out of 27 foetuses affected by clubfoot (41 feet) diagnosed at ultrasonography in the third trimester of pregnancy, only 8 (14 feet) had an isolated clubfoot (6 bilateral, 2 unilateral). Hence, ultrasound diagnosis of clubfoot should lead to doing amniocentesis as it may be associated with an abnormal karyotype in a high percentage of cases.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis of Clubfoot: A Review of Current Available Methodology

et al. 2017

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Background: Clubfoot is one of the most common congenital limb deformities. Prenatal diagnosis of the condition is essential as it can help treat the malformation as early as possible. We reviewed the recent available literature concerning the current methods for prenatal diagnosis of clubfoot. Methods:The following databases were searched from 1966 to 2015: PubMed, OVID, Cochrane, CINAHL, Google scholar and Embase. Results: Out of a total number of 197 retrieved articles, after abstract or title page evaluation, 158 articles not matching the inclusion criteria were excluded. The full text versions of the remaining 39 articles were obtained, and their reference lists screened, with the addition of another 5 full-text articles. Conclusions: Currently, ultrasonography is considered the most reliable method of prenatal diagnosis of clubfoot. Ultrasonographic diagnosis of clubfoot appears more likely between the 18th and the 24th week of pregnancy. Alternative imaging is not indicated. There is no agreement whether to propose foetal karyotyping when isolated clubfoot is diagnosed by prenatal ultrasonography. Early detection of clubfoot should prompt a careful surveillance during pregnancy in order to detect any possible additional abnormalities and, if any of these are detected, invasive testing should be off ered.

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Antenatal sonographic diagnosis of clubfoot: A six-year experience

Cited by 41 publications

References 16 publications

Frequency of Foetal Anomalies in a Tertiary Care Centre

Frequency of Foetal Anomalies in a Tertiary Care Centre

Prospective Evaluation of a Prenatal Sonographic Clubfoot Classification System

Prenatal Diagnosis of Clubfoot: A Review of Current Available Methodology

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