“…However, protection was not observed when the birth occurred before 24 hours of the administration of the first dose (RR 0.54; 95%CI: 0.21 to 1.36), but was observed when birth occurred before 48 hours after the administration of the first dose (RR 0.26; 95%CI: 0.09 to 0.75). 36 Steroid use alone is capable of altering the response of the assessed biomarkers, with decreased production of ROI and IL-6, 27,32,34,37 and may therefore prevent such markers from expressing themselves and being factors independently associated with PIVH. However, studies with controlled exposure to antenatal steroid use, in case of premature birth danger, would not be ethical.…”