“…Approximately twenty cases in pediatric population could be found with the use of available computer-assisted medical literature search programs. 3 , 5 , 6 , 10-12 Clinical and radiological features of our patient were similar of those described in the literature. 4 , 8 Histopathological analysis was compatible with a nephroblastoma blastemal type as described in the literature.…”
Neonatal nephroblastoma has been rarely reported in African neonate. A premature newborn (a 5-day-old male) was transferred with a history of neonatal abdominal mass. Ultrasonography revealed 75×46 mm, well-defined mass with mixed echogenicity replacing the right kidney. The patient underwent right radical nephrectomy and the tumor was confirmed to be a blastemal predominant Wilms’ tumor by the histopathological examination and has an unfavorable prognosis. The child died secondary to multiple organ failure, three days after surgery. Our case report serves to remind us the need to bear in mind the possibility of the diagnosis of neonatal nephroblastoma in neonate with renal mass.
“…Approximately twenty cases in pediatric population could be found with the use of available computer-assisted medical literature search programs. 3 , 5 , 6 , 10-12 Clinical and radiological features of our patient were similar of those described in the literature. 4 , 8 Histopathological analysis was compatible with a nephroblastoma blastemal type as described in the literature.…”
Neonatal nephroblastoma has been rarely reported in African neonate. A premature newborn (a 5-day-old male) was transferred with a history of neonatal abdominal mass. Ultrasonography revealed 75×46 mm, well-defined mass with mixed echogenicity replacing the right kidney. The patient underwent right radical nephrectomy and the tumor was confirmed to be a blastemal predominant Wilms’ tumor by the histopathological examination and has an unfavorable prognosis. The child died secondary to multiple organ failure, three days after surgery. Our case report serves to remind us the need to bear in mind the possibility of the diagnosis of neonatal nephroblastoma in neonate with renal mass.
“…[1] Antenatal detection of Wilms' tumor is very rare and only nine cases have been reported till now. [1][2][3][4][5][6][7] The index case was prenatally detected to have a renal mass at a primary health center in a peripheral village but no follow-up was done. The child presented to us after 7 months with advanced disease.…”
Antenatal detection of Wilms’ tumor is rare and only nine cases have been reported till now in the English literature. We report a case of a 7-month-old child with prenatally detected renal mass managed by nephroureterectomy associated with intraoperative spill. The child developed recurrence while on DD4A chemotherapy. Salvage chemotherapy was initiated but there was no response after two cycles and the child expired due to tumor rupture.
“…In these reports, prenatal WT is described as a solid echogenic mass or a heterogeneous lesion with multiple cystic areas due to hemorrhage or necrosis [5,21] . The mass may be unencapsulated or well defined.…”
Enlargement of a kidney on prenatal imaging is usually due to hydronephrosis or cystic renal disease, and much less often results from solid tumors such as mesoblastic nephroma, Wilms’ tumor, nephroblastomatosis, renal sarcoma, and angiomyolipoma. All can be diagnosed by ultrasound. Magnetic resonance imaging is useful not only in confirming the presence of a renal mass, but also in the evaluation of the contralateral kidney for subtle abnormalities. We present one case each of Wilms’ tumor and mesoblastic nephroma, both detected on antenatal ultrasound and further studied with fetal magnetic resonance imaging.
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