Antemortem diagnosis of asbestosis by screening chest radiograph correlated with postmortem histologic features of asbestosis: a study of 273 cases

Mizell, Kelly N.; Morris, Christopher G.; Carter, J Elliot

doi:10.1186/1745-6673-4-14

Cited by 6 publications

(5 citation statements)

References 8 publications

(17 reference statements)

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“…Information on study participants who received industrial injuries' compensation before 1997 was available: of the 363 participants certified as suffering from asbestosis with at least 10% disability, 303 (83%) had died by December 2005, 109 (30%) were listed on the Asbestosis Register, and 33 (30%) of the latter had asbestosis recorded as the underlying cause of death. These statistics highlight the difficulty, which has been reported elsewhere [e.g., Berry, 1981; Mizell et al, 2009], in ascertaining asbestosis cases using death certificate and clinical data rather than pathology/histology. While recognizing the limitations of the Asbestosis Register, and to a lesser extent the Mesothelioma Register, they do provide consistent data series over an extended period.…”

Section: Discussionmentioning

confidence: 72%

Asbestosis and mesothelioma among British asbestos workers (1971–2005)

Harding

Darnton

2010

American J Industrial Med

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Section: Discussionmentioning

confidence: 72%

Asbestosis and mesothelioma among British asbestos workers (1971–2005)

Harding

Darnton

2010

American J Industrial Med

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“…The advent of high resolution computed tomography enabled the identification of earlier radiological findings. However, this method is expensive and less commonly available, and trained professionals are necessary to interpret the examination [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Early Diagnosis of Respiratory Abnormalities in Asbestos-Exposed Workers by the Forced Oscillation Technique

et al. 2016

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BackgroundThe current reference test for the detection of respiratory abnormalities in asbestos-exposed workers is spirometry. However, spirometry has several shortcomings that greatly affect the efficacy of current asbestos control programs. The forced oscillation technique (FOT) represents the current state-of-the-art technique in the assessment of lung function. This method provides a detailed analysis of respiratory resistance and reactance at different oscillatory frequencies during tidal breathing. Here, we evaluate the FOT as an alternative method to standard spirometry for the early detection and quantification of respiratory abnormalities in asbestos-exposed workers.Methodology/Principal findingsSeventy-two subjects were analyzed. The control group was composed of 33 subjects with a normal spirometric exam who had no history of smoking or pulmonary disease. Thirty-nine subjects exposed to asbestos were also studied, including 32 volunteers in radiological category 0/0 and 7 volunteers with radiological categories of 0/1 or 1/1. FOT data were interpreted using classical parameters as well as integer (InOr) and fractional-order (FrOr) modeling. The diagnostic accuracy was evaluated by investigating the area under the receiver operating characteristic curve (AUC). Exposed workers presented increased obstruction (resistance p<0.001) and a reduced compliance (p<0.001), with a predominance of obstructive changes. The FOT parameter changes were correlated with the standard pulmonary function analysis methods (R = -0.52, p<0.001). Early respiratory abnormalities were identified with a high diagnostic accuracy (AUC = 0.987) using parameters obtained from the FrOr modeling. This accuracy was significantly better than those obtained with classical (p<0.001) and InOr (p<0.001) model parameters.ConclusionsThe FOT improved our knowledge about the biomechanical abnormalities in workers exposed to asbestos. Additionally, a high diagnostic accuracy in the diagnosis of early respiratory abnormalities in asbestos-exposed workers was obtained. This makes the FOT particularly useful as a screening tool in the context of asbestos control and elimination. Moreover, it can facilitate epidemiological research and the longitudinal follow-up of asbestos exposure and asbestos-related diseases.

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“…Parallel to mesothelioma risk trends, asbestosis is a fibrotic interstitial lung disease with a comparable latency period that has also generally diminished in both incidence and clinical severity in the past two decades. This trend has raised questions about how many valid asbestosis cases arise from the many claims that today are often based solely on equivocal radiographic findings and questionable occupational history of asbestos exposure (Bang et al, 2008 ; Mizell et al, 2009 ; Harding and Darnton, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Tumors that mimic asbestos-related mesothelioma: time to consider a genetics-based tumor registry?

Kerger¹,

James

Galbraith

2014

Front. Genet.

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The diagnosis of mesothelioma is not always straightforward, despite known immunohistochemical markers and other diagnostic techniques. One reason for the difficulty is that extrapleural tumors resembling mesothelioma may have several possible etiologies, especially in cases with no meaningful history of amphibole asbestos exposure. When the diagnosis of mesothelioma is based on histologic features alone, primary mesotheliomas may resemble various primary or metastatic cancers that have directly invaded the serosal membranes. Some of these metastatic malignancies, particularly carcinomas and sarcomas of the pleura, pericardium and peritoneum, may undergo desmoplastic reaction in the pleura, thereby mimicking mesothelioma, rather than the primary tumor. Encasement of the lung by direct spread or metastasis, termed pseudomesotheliomatous spread, occurs with several other primary cancer types, including certain late-stage tumors from genetic cancer syndromes exhibiting chromosomal instability. Although immunohistochemical staining patterns differentiate most carcinomas, lymphomas, and mestastatic sarcomas from mesotheliomas, specific genetic markers in tumor or somatic tissues have been recently identified that may also distinguish these tumor types from asbestos-related mesothelioma. A registry for genetic screening of mesothelioma cases would help lead to improvements in diagnostic criteria, prognostic accuracy and treatment efficacy, as well as improved estimates of primary mesothelioma incidence and of background rates of cancers unrelated to asbestos that might be otherwise mistaken for mesothelioma. This information would also help better define the dose-response relationships for mesothelioma and asbestos exposure, as well as other risk factors for mesothelioma and other mesenchymal or advanced metastatic tumors that may be indistinguishable by histology and staining characteristics.

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Antemortem diagnosis of asbestosis by screening chest radiograph correlated with postmortem histologic features of asbestosis: a study of 273 cases

Cited by 6 publications

References 8 publications

Asbestosis and mesothelioma among British asbestos workers (1971–2005)

Asbestosis and mesothelioma among British asbestos workers (1971–2005)

Early Diagnosis of Respiratory Abnormalities in Asbestos-Exposed Workers by the Forced Oscillation Technique

Tumors that mimic asbestos-related mesothelioma: time to consider a genetics-based tumor registry?

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