Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3

Ruan, Shuiliang; Han, Chenyang; Sheng, Yongjia; Wang, Jin; Zhou, Xin; Guan, Qing; Li, Wenyan; Zhang, Caiqun; Yang, Yi

doi:10.1016/j.intimp.2021.108126

Cited by 18 publications

(13 citation statements)

References 21 publications

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“…From there, the NLRP3 inflammasome is taken up by other cells, thus mediating inflammation and fibrosis (52). A study has confirmed that inhibition of pyroptosis can alleviate the inflammatory response of liver tissue by targeting the NLRP3 inflammasome (55). There is evidence that NLRP3 inflammasome plays a direct role during the development of NASH/NAFLD in mice models.…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

“…NLRP3 inflammasome gain of function leads to the early and severe onset of diet-induced steatohepatitis in mice ( 9 ). Inhibiting the NLRP3 inflammasome particularly alleviated inflammation, lipid accumulation, and fibrosis in NASH/NAFLD ( 5 , 55 , 57 – 59 ). Whereas there is also evidence that NLRP3 produces a hepatoprotective effect in NASH/NAFLD models.…”

Section: The Role Of Nlrp3 Inflammasome In the Pathomechanism Of Dige...mentioning

confidence: 99%

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NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Qiang

Dai

et al. 2022

Front. Immunol.

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Digestive system diseases remain a formidable challenge to human health. NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is the most characteristic multimeric protein complex and is involved in a wide range of digestive diseases as intracellular innate immune sensors. It has emerged as a research hotspot in recent years. In this context, we provide a comprehensive review of NLRP3 inflammasome priming and activation in the pathogenesis of digestive diseases, including clinical and preclinical studies. Moreover, the scientific evidence of small‐molecule chemical drugs, biologics, and phytochemicals, which acts on different steps of the NLRP3 inflammasome, is reviewed. Above all, deep interrogation of the NLRP3 inflammasome is a better insight of the pathomechanism of digestive diseases. We believe that the NLRP3 inflammasome will hold promise as a novel valuable target and research direction for treating digestive disorders.

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Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Section: The Role Of Nlrp3 Inflammasome In the Pathomechanism Of Dige...mentioning

confidence: 99%

NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Qiang

Dai

et al. 2022

Front. Immunol.

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“…The followed amplified inflammatory response can stimulate the activation of HSC and secrete ECM, leading to the occurrence of liver fibrosis. Macrophages pyroptosis also participates in liver fibrogenesis in NAFLD and CCL4‐induced models 54,55 . In addition, the release of mitochondrial DNA can induce NLRP3 inflammasome activation in Kupffer cells and drive IL‐1β secretion in NASH mouse model 56 .…”

Section: Main Hepatic Cells Undergoing Pyroptosis In Liver Fibrosismentioning

confidence: 99%

“…Macrophages pyroptosis also participates in liver fibrogenesis in NAFLD and CCL4‐induced models. 54 , 55 In addition, the release of mitochondrial DNA can induce NLRP3 inflammasome activation in Kupffer cells and drive IL‐1β secretion in NASH mouse model. 56 Furthermore, recent study reveals that LPS can lead to the expression of cathepsin B, which gradually activates caspase‐11 in Kupffer cells and induce noncanonical pyroptosis, resulting in liver damage.…”

Section: Main Hepatic Cells Undergoing Pyroptosis In Liver Fibrosismentioning

confidence: 99%

Multi‐faceted role of pyroptosis mediated by inflammasome in liver fibrosis

Yang

Wang

Liu

2022

J Cellular Molecular Medi

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Liver fibrosis is a reversible pathological overreaction during the self‐repair of liver injuries, and it is the common period of chronic liver diseases induced by different pathogenesis progress into cirrhosis and even hepatocellular carcinoma. Pyroptosis, a novel form of programmed cell death, is reported to take part in the pathogenesis and progression of acute or chronic liver diseases and liver fibrosis. Caspase‐1 dependent canonical pathway and caspase‐4/‐5/‐11 mediated noncanonical pathway are the two signalling pathways to induce pyroptosis. The activation of inflammasomes under the stimulation of pathogenic microorganisms and danger signals can initiate the pyroptotic pathway and release large amounts of proinflammatory and profibrotic cytokines. This article comprehensively summarizes recent researches focused on the mechanism of pyroptosis and its role in major hepatic cells, which can provide potential therapeutic strategies for liver fibrosis.

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“…The cell membrane pore permeability and the number of pyroptotic cells significantly decreased after treatment with Antcin A. It worked by binding to NLRP3 and inhibiting the assembly and activation of the NLRP3 inflammasome, further mediating the inflammatory response and pyroptosis and thereby improving NASH (Ruan et al, 2021). Ginseng saponins can be divided into Rg1, Re, Rg2, Rh1, Rf, Rb1, Rb2, Rd, Rg3, Rh2, and Ro.…”

Section: Antcin Amentioning

confidence: 99%

Plant-derived bioactive compounds regulate the NLRP3 inflammasome to treat NAFLD

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is a liver disorder characterized by abnormal accumulation of hepatic fat and inflammatory response with complex pathogenesis. Over activation of the pyrin domain-containing protein 3 (NLRP3) inflammasome triggers the secretion of interleukin (IL)-1β and IL-18, induces pyroptosis, and promotes the release of a large number of pro-inflammatory proteins. All of which contribute to the development of NAFLD. There is a great deal of evidence indicating that plant-derived active ingredients are effective and safe for NAFLD management. This review aims to summarize the research progress of 31 active plant-derived components (terpenoids, flavonoids, alkaloids, and phenols) that alleviate lipid deposition, inflammation, and pyroptosis by acting on the NLRP3 inflammasome studied in both in vitro and in vivo NAFLD models. These studies confirmed that the NLRP3 inflammasome and its related genes play a key role in NAFLD amelioration, providing a starting point for further study on the correlation of plant-derived compounds treatment with the NLRP3 inflammasome and NAFLD.

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Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3

Cited by 18 publications

References 21 publications

NLRP3 inflammasome in digestive diseases: From mechanism to therapy

NLRP3 inflammasome in digestive diseases: From mechanism to therapy

Multi‐faceted role of pyroptosis mediated by inflammasome in liver fibrosis

Plant-derived bioactive compounds regulate the NLRP3 inflammasome to treat NAFLD

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