Multi‐faceted role of pyroptosis mediated by inflammasome in liver fibrosis

Yang, Hui; Wang, Juan; Liu, Zhenguo

doi:10.1111/jcmm.17277

Cited by 10 publications

(6 citation statements)

References 86 publications

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“…Pyroptosis, a recently identified form of programmed cell death, exists exclusively in dendritic cells and macrophages [ 8 ]. Moreover, it occurs in other organs, including the liver [ 9 ] and kidneys [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis

Abdellatif

Nasef

El‐Horany

et al. 2022

IJMS

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Doxorubicin (DOX) is an anticancer antibiotic which has various effects in human cancers. It is one of the commonly known causes of drug-induced nephrotoxicity, which results in acute renal injury. Adrenomedullin (ADM), a vasodilator peptide, is widely distributed in many tissues and has potent protective effects. Therefore, the current study aimed to examine the protective potential mechanisms of ADM against DOX-induced nephrotoxicity. A total of 28 male Wistar rats were randomized into four groups: control group, doxorubicin group (15 mg/kg single intraperitoneal injection of DOX), adrenomedullin + doxorubicin group (12 μg/kg/day intraperitoneal injection of ADM) 3 days prior to DOX injection and continuing for 14 days after the model was established, and adrenomedullin group. Kidney function biomarkers, oxidative stress markers, and inflammatory mediators (TNF-α, NLRP3, IL-1β, and IL-18) were assessed. The expressions of gasdermin D and ASC were assessed by real-time PCR. Furthermore, the abundances of caspase-1 (p20), Bcl-2, and Bax immunoreactivity were evaluated. ADM administration improved the biochemical parameters of DOX-induced nephrotoxicity, significantly reduced oxidative damage markers and inflammatory mediators, and suppressed both apoptosis and pyroptosis. These results were confirmed by the histopathological findings and revealed that ADM’s antioxidant, anti-inflammatory, anti-apoptotic, and anti-pyroptotic properties may have prospective applications in the amelioration of DOX-induced nephrotoxicity.

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Section: Introductionmentioning

confidence: 99%

Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis

Abdellatif

Nasef

El‐Horany

et al. 2022

IJMS

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“…Therefore, a large proportion of patients still do not have adequate treatment, and understanding the mechanisms of the proinflammatory pathway in AILDs and potential new therapeutic approaches is critical. Experimental studies on AILDs have repeatedly demonstrated that the inflammasome is essential for the development of liver fibrosis and damage as a result of chronic inflammation ( 202 ). According to the latest available dta, dimethyl fumarate, cucurbitacin E, paeoniflorin, MCC950, IDN-7314, and geniposidic acid could inhibit the activation of NLRP3 inflammasome and the secretion of IL-1β, while bongkrekic acid and schisandra phenol B could inhibit the activation of APAF-1 and GSDME-dependent pyroptosis, thereby alleviating liver inflammatory damage in AILDs mouse models.…”

Section: Discussionmentioning

confidence: 99%

Inflammasome and pyroptosis in autoimmune liver diseases

et al. 2023

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Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and IgG4-related sclerosing cholangitis (IgG4-SC) are the four main forms of autoimmune liver diseases (AILDs), which are all defined by an aberrant immune system attack on the liver. Most previous studies have shown that apoptosis and necrosis are the two major modes of hepatocyte death in AILDs. Recent studies have reported that inflammasome-mediated pyroptosis is critical for the inflammatory response and severity of liver injury in AILDs. This review summarizes our present understanding of inflammasome activation and function, as well as the connections among inflammasomes, pyroptosis, and AILDs, thus highlighting the shared features across the four disease models and gaps in our knowledge. In addition, we summarize the correlation among NLRP3 inflammasome activation in the liver-gut axis, liver injury, and intestinal barrier disruption in PBC and PSC. We summarize the differences in microbial and metabolic characteristics between PSC and IgG4-SC, and highlight the uniqueness of IgG4-SC. We explore the different roles of NLRP3 in acute and chronic cholestatic liver injury, as well as the complex and controversial crosstalk between various types of cell death in AILDs. We also discuss the most up-to-date developments in inflammasome- and pyroptosis-targeted medicines for autoimmune liver disorders.

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“…LPS then binds to procaspase‐4, procaspase‐5, and procaspase‐11 and cleaves them. Activated caspase‐4, ‐5, and ‐11 then hydrolyze GSDMD, and the resulting GSDMD‐N induces cell membrane perforation and activates the receptor pannexin‐1 to open the cell membrane channels, resulting in the efflux of P2X7, ATP, HMGB1, K + , and lactate dehydrogenase (LDH); release of inflammatory factors; and pyroptosis (Jorgensen & Miao, 2015; Yang et al, 2022). Caspase‐11 induces the noncanonical activation of NLRP3, which in turn induces caspase‐1 cleavage and proinflammatory factor production (Moretti et al, 2022).…”

Section: Liver Diseases and Pyroptosismentioning

confidence: 99%

Recent advances in pyroptosis, liver disease, and traditional Chinese medicine: A review

He,

Xu,

Mao

et al. 2023

Phytotherapy Research

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In recent years, the incidence of liver disease has increased, becoming a major cause of death. Various liver diseases are intricately linked to pyroptosis, which is one of the most common forms of programmed cell death. As a powerful weapon in the fight against liver diseases, traditional Chinese medicine (TCM) can affect pyroptosis via a number of routes, including the classical, nucleotide oligomerization domain‐like receptors protein 3/caspase‐1/gasdermin D (GSDMD) pathway, the nonclassical lipopolysaccharide/caspase‐11/GSDMD pathway, the ROS/caspase‐3/gasdermin E pathway, the caspase‐9/caspase‐3/GSDMD pathway, and the Apaf‐1/caspase‐11/caspase‐3 pathway. In this review, we provide an overview of pyroptosis, the interplay between pyroptosis and liver diseases, and the mechanisms through which TCM regulates pyroptosis in liver diseases. The information used in the text was collected and compiled from the databases of PubMed, Web of Science, Scopus, CNKI, and Wanfang Data up to June 2023. The search was not limited with regard to the language and country of the articles. Research and review articles were included, and papers with duplicate results or unrelated content were excluded. We examined the current understanding of the relationship between pyroptosis and liver diseases as well as the advances in TCM interventions to provide a resource for the identification of potential targets for TCM in the treatment of liver diseases.

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Multi‐faceted role of pyroptosis mediated by inflammasome in liver fibrosis

Cited by 10 publications

References 86 publications

Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis

Adrenomedullin Mitigates Doxorubicin-Induced Nephrotoxicity in Rats: Role of Oxidative Stress, Inflammation, Apoptosis, and Pyroptosis

Inflammasome and pyroptosis in autoimmune liver diseases

Recent advances in pyroptosis, liver disease, and traditional Chinese medicine: A review

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