Antagonists of platelet activating factor from (L.) JACQ

Kadota, Shigetoshi; Marpaung, Lamek; Kikuchi, Tohru; Ekimoto, Hisao

doi:10.1016/s0040-4039(01)80373-7

Cited by 32 publications

(63 citation statements)

References 5 publications

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“…Kadota et al published the first example of limonoids having antagonistic effects on PAF, finding the following rank order of inhibition at 100 μg/mL: swietemahonin A ( 79 ), 97.4%; swietemahonin E ( 83 ), 91.7%; 3- O -acetylswietenolide ( 24 ), 91.6%; swietenolide ( 23 ), 35.2% [ 52 ]. In other examples, swietemahonins A, D, E, G ( 79 , 81 – 82 , 85 ), 3- O -acetylswietenolide ( 24 ) and 6- O -acetylswietenolide ( 25 ), strongly inhibited PAF-induced aggregation of rabbit platelets in vitro, giving IC 50 values of 40.2, 40.3, 51.2, 42.6, 52.9, 80.4 and 55.6 μg/mL.…”

Section: Biological Activitiesmentioning

confidence: 99%

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

et al. 2018

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Swietenia is a genus in the plant family Meliaceae. This genus contains seven to eight known species, found in the tropical and subtropical regions of the Americas and West Africa. Thus far, more than 160 limonoids have been isolated from four species of the genus Swietenia. Limonoids are rich in structure type and biological activity, and these compounds are the main active components in the Swietenia species. This paper will give a comprehensive overview of the recent phytochemical and pharmacological research on the terpenes from Swietenia plants and encourage further drug discovery research.

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Section: Biological Activitiesmentioning

confidence: 99%

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

et al. 2018

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“…Several compounds have been reported with double bond in different positions i.e between C-8 and C-30, C-8 and C-14, and C-8 and C-9. For example, in swietenine (42) [14][15][16][17][18][19] the double bond is present between C-8 and C-30, the concerned signals appeared at 138.2 and 123.6 ppm, respectively, and the carbonyl (C-1) appeared at 216.5 ppm. In swietenolides [20][21] double bond exists between C-8 and C-14, the chemical shift values appeared for these signals are 129.0 and 130.7 ppm, respectively.…”

Section: Methyl Meliacatesmentioning

confidence: 99%

¹³C NMR spectroscopy of D and B, D-ring seco-limonoids of Meliaceae family§

Narender

Khaliq

Shweta

2008

Natural Product Research

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The modified limonoids isolated from the Meliaceae are too complex or obtained in too small quantities to determine their structures by chemical and spectroscopic means, including 1H NMR. One method of dealing with such problem is direct crystallographic analysis, without or having a heavy atom, which requires an able crystallographic collaborator. The determination of the structure Utilin is one example. The analysis of the 13C NMR spectral data for different compounds has been very useful for the identification of the various skeletal types of limonoids and also for the determination of the substitution pattern. Owing to the great utilities that these data could help the scientific community, who are working in the area of limonoids, we here describe the application of NMR spectroscopy in the structure elucidation of D and B, D-ring seco-limonoids and a collection of 177 compound's 13C NMR spectral data.

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“…The three species have previous reports validating some of the traditional uses or of promising bioactivities in the laboratory. In the case of S. mahagoni the antagonist activity of the plateletactivating factor was determined (Kadota et al, 1989). In addition, methyl esters of the cholinergic acid with a high antioxidant activity were reported for this species (Matsuse et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Antioxidants from three Swietenia Species (Meliaceae)

Preciado¹,

Lobo-Echeverri²,

PereaÃ±ez³

et al. 2016

J. Med. Plants Res.

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The genus Swietenia (Meliaceae) has a wide variety of secondary metabolites with reported antioxidant activity, such as flavonoids and limonoids. In the present study, the antioxidant capacity, along with the phenol and flavonoid contents of the leaf extracts of three species of this genus: Swietenia mahagoni, Swietenia macrophylla, and Swietenia humilis were evaluated. The antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), ferric reducing/antioxidant power (FRAP), and oxygen radical absorbance capacity (ORAC) methods. The results showed that the three species had significant antioxidant activity and substantial contents of phenolic compounds and flavonoids. The species S. macrophylla was the most effective, and compounds with recognized antioxidant capability were detected by gas chromatography coupled with mass spectrometry (GC-MS). Catechin was the most abundant constituent in the active fractions, and was confirmed and quantified by high performance liquid chromatography (HPLC).

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Antagonists of platelet activating factor from (L.) JACQ

Cited by 32 publications

References 5 publications

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

¹³C NMR spectroscopy of D and B, D-ring seco-limonoids of Meliaceae family§

Antioxidants from three Swietenia Species (Meliaceae)

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Antagonists of platelet activating factor from (L.) JACQ

Cited by 32 publications

References 5 publications

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

Chemical Structures and Biological Activities of Limonoids from the Genus Swietenia (Meliaceae)

13C NMR spectroscopy of D and B, D-ring seco-limonoids of Meliaceae family§

Antioxidants from three Swietenia Species (Meliaceae)

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Product

Resources

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¹³C NMR spectroscopy of D and B, D-ring seco-limonoids of Meliaceae family§