Antagonists of Histamine, 5-Hydroxytryptamine and SRS-A

Green, A. F.; Garland, L.G.; Hodson, H. F.

doi:10.1007/978-3-642-66891-3_15

Cited by 9 publications

(8 citation statements)

References 126 publications

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“…However, in our rat model, a relatively high concentration of this prostanoid did not cause overt venular PMNL accumulation. Our findings in the rat thus suggest that while 5‐HT is crucial for mast cell‐dependent plasma extravasation in the rat (Green et al , 1979; Raud et al , 1995), initiation of PMNL rolling is mainly dependent on the release of histamine.…”

Section: Discussionmentioning

confidence: 61%

“…However, in our rat model, a relatively high concentration of this prostanoid did not cause overt venular PMNL accumulation. Our ®ndings in the rat thus suggest that while 5-HT is crucial for mast cell-dependent plasma extravasation in the rat (Green et al, 1979;Raud et al, 1995), initiation of PMNL rolling is mainly dependent on the release of histamine. By use of intravital microscopy, we have previously shown that, in addition to increased rolling, challenge with compound 48/80 also causes signi®cant ®rm leukocyte adhesion (Thorlacius et al, 1994), most likely due to release of mast cell-derived chemotactic factors, such as plateletactivating factor and dierent leukocyte-attracting cytokines (Harvima & Schwartz 1993).…”

Section: Discussionmentioning

confidence: 62%

“…However, it is not known if 5‐HT, similar to histamine, can induce leukocyte rolling in vivo. Because 5‐HT is an important mediator of acute mast cell‐dependent oedema in the rat and is approximately 100 times more potent than histamine in this respect (Green et al , 1979), we first analysed the relative role of histamine and 5‐HT in acute mast cell‐dependent venular PMNL recruitment. Mast cell activation was achieved by i.p.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of histamine‐induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery

Yamaki

Thorlacius

Xie

et al. 1998

British J Pharmacology

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1 The main objective of this study was to analyse the role and mode of action of the mast cell mediator histamine in leukocyte-endothelium interactions in small venules in vivo. For this purpose, we used a histological approach (combined with intravital microscopy) that allows studies of rapid mediatorinduced venular leukocyte accumulation, re¯ecting leukocyte rolling, in the undisturbed microcirculation of the rat mesentery where rolling is normally absent. 2 We ®rst examined the relative importance of histamine and 5-hydroxytryptamine (5-HT) in acute mast cell-dependent leukocyte recruitment. The mast cell secretagogue compound 48/80 (i.p. for 15 min) induced a marked venular accumulation of polymorphonuclear leukocytes (PMNL) which was almost abolished by combined histamine 1 (H 1 )-and histamine 2 (H 2 )-receptor blockade. In contrast, the 5-HTreceptor antagonist methysergide was inactive in this regard. Moreover, exogenous 5-HT was less active than exogenous histamine in evoking venular PMNL accumulation (histamine response dose-dependent; 5-HT response bell shaped). Prostaglandin D 2 did not cause PMNL accumulation. 3 The venular PMNL response to exogenous histamine peaked between 15 min and 1 h, was still signi®cantly elevated at 2 h, and then returned to prechallenge values after 3 h. At all time points, the histamine-induced PMNL accumulation was nearly abolished by i.v. treatment with the polysaccharide fucoidin (which blocks rolling but not ®rm adhesion per se), suggesting that the PMNL response to histamine was due to rolling rather than ®rm adhesion over the entire 3 h period. At no time point did histamine trigger accumulation of mononuclear leukocytes (MNL). 4 To examine the role of histamine-receptors in the histamine-induced PMNL accumulation (i.e. rolling), the animals were pretreated with diphenhydramine (H 1 -receptor antagonist), cimetidine, or ranitidine (H 2 -receptor antagonists). Diphenhydramine alone inhibited the venular PMNL response to histamine by 52%, while both H 2 -receptor antagonists were completely inactive. However, the combination of cimetidine and diphenhydramine reduced the histamine-induced PMNL rolling by 82%. Furthermore, in contrast to an H 3 -receptor agonist, challenge with either the H 1 -receptor agonist 2-thiazolylethylamine or two di erent H 2 -receptor agonists (impromidine, dimaprit) was su cient to provoke signi®cant venular PMNL accumulation. 5 Treatment with the nitric oxide-synthase inhibitor L-NAME did not a ect the histamine-induced PMNL rolling. On the other hand, 3 h pretreatment with dexamethasone reduced the PMNL response to histamine by 73%, and¯ow cytometric analysis showed that the dexamethasone treatment almost completely inhibited binding of soluble P-selectin to rat isolated PMNLs. 6 We conclude that initial leukocyte recruitment after mast cell activation in the rat mesentery is critically dependent on histamine release. The cellular response to histamine was speci®cally due to PMNL rolling, involved activation of both H 1 -and H 2 -receptors, ...

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of histamine‐induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery

Yamaki

Thorlacius

Xie

et al. 1998

British J Pharmacology

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show abstract

“…Herpes simplex and inflammation in skin All of the PG levels in treated mice were significantly different by Student's t-test from those in untreated mice (P < 0.001) with the exception of those marked: a, P < 0.01; b, P < 0.05; c, P > 0.05. stimulus, but stripping or the application of xylene or DMSO to skin was followed by increased vascular permeability which could be assayed by measuring the intensity and extent of dye leakage into the tissue. Thus, the action of the stimuli could in part be analysed by studying the effects on the extravasation of dye of drugs antagonistic to particular mediators of inflammation (Green et at., 1979). The drugs were mepyramine (antihistamine), methysergide (antiserotonin) and cyproheptadine (non-specific ant±amine).…”

Section: Isolation Jrom Skinmentioning

confidence: 99%