Antagonistic Activity of Spent Culture Supernatants of Lactic Acid Bacteria against Helicobacter Pylori Growth and Infection in Human Gastric Epithelial AGS Cells

Lin, Wen-Hsin; Lin, Chi-Ying; Sheu, Sen-Je; Hwang, Chin‐Fa; Ye, Wan-Ting; Hwang, Wen-Zhe; Tsen, Hau‐Yang

doi:10.1111/j.1750-3841.2009.01194.x

Cited by 34 publications

(18 citation statements)

References 44 publications

(55 reference statements)

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“…Upon recognition, enterocytes secrete TGF-β and IL-8, which in turn modulate the immune response. Despite the fact that the WHO dictates that microorganisms must be viable to be considered as probiotics, there is evidence that shows that inactivated or heat-killed bacteria, as well as isolated purified molecules, can exert effects on the GALT [18,19,20,21,22,23]. In fact, it has been suggested to name these soluble probiotic-derived molecules as “probiotaceuticals” [24].…”

Section: Probiotics and Gut-associated Lymphoid Tissuementioning

confidence: 99%

Message in a Bottle: Dialog between Intestine and Skin Modulated by Probiotics

Friedrich

Paz

Leoni

et al. 2017

IJMS

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At the beginning, probiotics were used exclusively for gastrointestinal conditions. However, over the years, evidence has shown that probiotics exert systemic effects. In this review article, we will summarize recent reports that postulate probiotic treatment as an efficient one against skin pathologies, such as cancer, allergy, photoaging and skin infections. The focus will be restricted to oral probiotics that could potentially counteract the ultraviolet irradiation-induced skin alterations. Moreover, the possible underlying mechanisms by which probiotics can impact on the gut and exert their skin effects will be reviewed. Furthermore, how the local and systemic immune system is involved in the intestine-cutaneous crosstalk will be analyzed. In conclusion, this article will be divided into three core ideas: (a) probiotics regulate gut homeostasis; (b) gut and skin homeostasis are connected; (c) probiotics are a potentially effective treatment against skin conditions.

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Section: Probiotics and Gut-associated Lymphoid Tissuementioning

confidence: 99%

Message in a Bottle: Dialog between Intestine and Skin Modulated by Probiotics

Friedrich

Paz

Leoni

et al. 2017

IJMS

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“…In addition, heat-killed 06TCa19 and 07MR044 cells did not produce inhibitory zones, respectively. Some H. pylori growth-inhibiting activities by LAB are reportedly attributable to the production of organic acids (Aiba et al, 1998;Lin et al, 2009;Midolo et al, 1995). On the other hand, H. pylori growth inhibition by LAB has been reported to depend on the cell wall fraction and bacteriocin (Rokka et al, 2006;Simova et al, 2009).…”

Section: Identification Of the Active Anti-h Pylori Component(s) In mentioning

confidence: 99%

“…This ability of 06TCa19 may contribute to the anti-H. pylori activity. On the other hand, Lin et al (2009) stated that the anti-H. pylori activity was due to the acetic acid as well as the lactic acid produced in the culture medium. Acetic acid was detected in the H. pylori culture inoculated with PBS, and no significant differences were observed in the concentrations of acetic acid in this study (Table 3).…”

Section: Analysis Of Organic Acids In Co-cultured H Pylori and Labmentioning

confidence: 99%

“…Therefore, the large amount of l-lactic acid produced by strain 06TCa19 during early-stage co-culture was inferred to contribute to the growth inhibition of H. pylori. In addition, the large amount of organic acids, including lactic acid, produced by LAB in culture can reportedly inhibit H. pylori adhesion and invasion of gastric cell lines in vitro (Lin et al, 2009). The large amount of l-lactic acid produced by strain 06TCa19 is expected to inhibit the adhesion of H. pylori to human gastric cells.…”

Section: Strainmentioning

confidence: 99%

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In Vitro and In Vivo Anti-Helicobacter pylori Activity of Probiotics Isolated from Mongolian Dairy Products

Takeda

Takeshita

Matsusaki

et al. 2015

FSTR

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Helicobacter (H.) pylori is known to be a bacterial risk factor for gastric cancer. In this study, 16 strains of lactic acid bacteria (LAB) isolated from Mongolian dairy products were screened for potential probiotic activity against H. pylori strain no. 130 in vitro. Lactobacillus (L.) paracasei 06TCa19 and L. plantarum 07MR044 were identified as LAB strains with anti-H. pylori activities. Compared to strain 07MR044, strain 06TCa19 was more potent in reducing H. pylori counts in co-culture. The ability of strain 06TCa19 to inhibit the growth of H. pylori was attributable to its rapid and excessive generation of lactic acid. Moreover, oral administration of strain 06TCa19 was found to significantly reduce the number of colonizing H. pylori in the stomach of H. pylori strain no. 130-infected mice. Thus, strain 06TCa19 is potentially effective against H. pylori infection.

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“…There is, however, no agreement about the underlying mechanisms. Currently, several hypotheses based on in vitro studies have been proposed: inhibition of adhesion of H. pylori cells to gastric epithelial cells [38,42,44,54,57]; production of organic acids-mainly lactic acid-by the probiotic strains, and low pH [1,8,44]; secretion of an antibacterial substance different from lactic acid [3,12,13,47,57,60]; a combined effect of lactic acid and other extracellularly secreted compounds [52,79]; an intracellular compound that is released after cell lysis [46]; and immunomodulation [63,68,82].…”

Section: Introductionmentioning

confidence: 99%

Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori

Vuyst

Vincent

Makras

et al. 2009

Probiotics & Antimicro. Prot.

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Helicobacter pylori inhibition by probiotic lactobacilli has been observed in vitro and in vivo. Carefully selected probiotic Lactobacillus strains could therefore play an important role in the treatment of H. pylori infection and eradication. However, the underlying mechanism for this inhibition is not clear. The aim of this study was to examine if peptide extracts, containing bacteriocins or other antibacterial peptides, from six Lactobacillus cultures (Lactobacillus acidophilus La1, Lactobacillus amylovorus DCE 471, Lactobacillus casei YIT 9029, Lactobacillus gasseri K7, Lactobacillus johnsonii La1, and Lactobacillus rhamnosus GG) contribute to the inhibition of H. pylori. Peptide extracts from cultures of Lact. amylovorus DCE 471 and Lact. johnsonii La1 were most active, reducing the viability of H. pylori ATCC 43504 with more than 2 log units within 4 h of incubation (P < 0.001). The four other extracts were less or not active. When six clinical isolates of H. pylori were tested for their susceptibility towards five inhibitory peptide extracts, similar observations were made. Again, the peptide extracts from Lact. amylovorus DCE 471 and Lact. johnsonii La1 were the most inhibitory, while the three other extracts resulted in a much lower inhibition of H. pylori. Protease-treated extracts were inactive towards H. pylori, confirming the proteinaceous nature of the inhibitory substance.

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Antagonistic Activity of Spent Culture Supernatants of Lactic Acid Bacteria against Helicobacter Pylori Growth and Infection in Human Gastric Epithelial AGS Cells

Cited by 34 publications

References 44 publications

Message in a Bottle: Dialog between Intestine and Skin Modulated by Probiotics

Message in a Bottle: Dialog between Intestine and Skin Modulated by Probiotics

<i>In Vitro</i> and <i>In Vivo</i> Anti-<i>Helicobacter pylori</i> Activity of Probiotics Isolated from Mongolian Dairy Products

Peptide Extracts from Cultures of Certain Lactobacilli Inhibit Helicobacter pylori

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