Antagonism by salvianolic acid B of lipopolysaccharide‐induced disseminated intravascular coagulation in rabbits

Wu, Zheng; Li, Jiannan; Bai, Zhi-quan; Lin, Xiao

doi:10.1111/1440-1681.12242

Cited by 13 publications

(6 citation statements)

References 25 publications

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“…In platelets, Sal-B significantly inhibits ADP and thrombininduced platelet aggregation by reducing the release of soluble P-selectin and antagonizing the activity of phosphodiesterase (PDE) and P2Y12 receptor [130,149,150] . As a result, Sal-B reduces the adhesion of ADP-activated platelets to endothelial cells via the NF-κB-driven inflammatory response [149] and limits LPS-induced disseminated intravascular coagulation in rabbits [151] .…”

Section: Inhibitory Effects Of Sal-b On Platelet Aggregationmentioning

confidence: 99%

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

2018

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Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used in Asian countries for many centuries. Accumulating evidence suggests that Danshen and its components prevent vascular diseases, in particular, atherosclerosis and cardiac diseases, including myocardial infarction, myocardial ischemia/reperfusion injury, arrhythmia, cardiac hypertrophy and cardiac fibrosis. The published literature indicates that lipophilic constituents (tanshinone I, tanshinone IIa, tanshinone IIb, cryptotanshinone, dihydrotanshinone, etc) as well as hydrophilic constituents (danshensu, salvianolic acid A and B, protocatechuic aldehyde, etc) contribute to the cardiovascular protective actions of Danshen, suggesting a potential synergism among these constituents. Herein, we provide a systematic up-to-date review on the cardiovascular actions and therapeutic potential of major pharmacologically active constituents of Danshen. These bioactive compounds will serve as excellent drug candidates in small-molecule cardiovascular drug discovery. This article also provides a scientific rationale for understanding the traditional use of Danshen in cardiovascular therapeutics.

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Section: Inhibitory Effects Of Sal-b On Platelet Aggregationmentioning

confidence: 99%

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

2018

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“…In addition, damaged tissues can promote platelet aggregation through adhesion molecules, and activated platelets are initiators and/or enhancers of the inflammatory response (Nieswandt et al, 2011). Sal B can significantly inhibit the adhesion and aggregation of platelets in the rabbit model of diffuse intravascular coagulation induced by lipopolysaccharide (LPS) (Wu et al, 2014). Further studies on endothelial cells have shown that Sal B can inhibit the expression of platelet P-selectin (Stumpf et al, 2013), inhibit the expression and release of adhesion molecules and chemokines, and attenuate platelet-induced endothelial cell inflammation by inhibiting NF-κB activation (Xu et al, 2015).…”

Section: Pharmacological Mechanisms Of Salvianolic Acid B Based On Anmentioning

confidence: 99%

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage

Xiao¹,

Liu²,

Mu³

et al. 2020

Front. Pharmacol.

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Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza, with strong antioxidant effects. Recent findings have shown that Sal B has anti-inflammatory, anti-apoptotic, anti-fibrotic effects and can promote stem cell proliferation and differentiation, and has a beneficial effect on cardiovascular and cerebrovascular diseases, aging, and liver fibrosis. Reactive oxygen species (ROS) include oxygen free radicals and oxygen-containing non-free radicals. ROS can regulate cell proliferation, survival, death and differentiation to regulate inflammation, and immunity, while Sal B can scavenge oxygen free radicals by providing hydrogen atoms and reduce the production of oxygen free radicals and oxygen-containing non-radicals by regulating the expression of antioxidant enzymes. The many pharmacological effects of Sal B may be closely related to its elimination and inhibition of ROS generation, and Nuclear factor E2-related factor 2/Kelch-like ECH-related protein 1 may be the core link in its regulation of the expression of antioxidant enzyme to exert its antioxidant effect. What is confusing and interesting is that Sal B exhibits the opposite mechanisms in tumors. To clarify the specific target of Sal B and the correlation between its regulation of oxidative stress and energy metabolism homeostasis will help to further understand its role in different pathological conditions, and provide a scientific basis for its further clinical application and new drug development. Although Sal B has broad prospects in clinical application due to its extensive pharmacological effects, the low bioavailability is a serious obstacle to further improving its efficacy in vivo and promoting clinical application. Therefore, how to improve the availability of Sal B in vivo requires the joint efforts of many interdisciplinary subjects.

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“…Endotoxin (LPS) may also induce a runaway form of hypercoagulation 57 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 known as disseminated intravascular coagulation (DIC). There is significant evidence now that DIC is reasonably well defined 46 118 119 120 and that it can directly lead to MOF and death (Cunningham and Nelson, 121 and see the following).…”

Section: Normal Blood Coagulation and Coagulopathiesmentioning

confidence: 99%

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

Kell

Pretorius

2017

Semin Thromb Hemost

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A well-established development of increasing disease severity leads from sepsis through systemic inflammatory response syndrome, septic shock, multiple organ dysfunction syndrome, and cellular and organismal death. Less commonly discussed are the equally well-established coagulopathies that accompany this. We argue that a lipopolysaccharide-initiated (often disseminated intravascular) coagulation is accompanied by a proteolysis of fibrinogen such that formed fibrin is both inflammatory and resistant to fibrinolysis. In particular, we argue that the form of fibrin generated is amyloid in nature because much of its normal α-helical content is transformed to β-sheets, as occurs with other proteins in established amyloidogenic and prion diseases. We hypothesize that these processes of amyloidogenic clotting and the attendant coagulopathies play a role in the passage along the aforementioned pathways to organismal death, and that their inhibition would be of significant therapeutic value, a claim for which there is considerable emerging evidence.

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Antagonism by salvianolic acid B of lipopolysaccharide‐induced disseminated intravascular coagulation in rabbits

Cited by 13 publications

References 25 publications

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

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