ANRIL polymorphism rs1333049, a novel genetic predictor for diabetic retinopathy complication

Siddiqui, Amna R.; Hussain, Shahzad; Azam, Aisha; Muslim, Irfan; Maqsood, Sundus Ijaz; Ahmed, Waqas; Murad, M. Hassan; Niazi, Muhammad Khizar; Ishaq, Mazhar; Waheed, Nadia K.; Qamar, Raheel; Azam, Maleeha

doi:10.1016/j.mgene.2017.07.011

Cited by 2 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetic retinopathy is a severe diabetic complication and is currently the leading cause of blindness worldwide, but its pathogenesis is not yet clear, and its therapeutic effect is not promising [19]. According to Siddiqui A et al, lncRNA-ANRIL might be a genetic predictor for DR [20]. Anu Alice Thomas et al revealed that ANRIL expression can be upregulated in vascular endothelial cells through PRC2, miR200b and p300 and that ANRIL can mediate the proliferation of retinal vascular endothelial cells and participate in the pathogenesis of DR [18].…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of long non-coding RNA ANRIL level in diabetic retinopathy

et al. 2019

View full text Add to dashboard Cite

Aim To analyse the expression of lncRNA-ANRIL and other related factors in different human body fluids, explore the clinical significance of ANRIL and validate whether ANRIL is interrelated with the renin-angiotensin system and NF-κB signalling pathway. Methods Ninety-one patients were included in this cross-sectional study and were divided into the NDM group (20 patients), DM group (25 patients), NPDR group (21 patients) and PDR group (25 patients). Basic information and samples of serum, aqueous fluid and vitreous fluid were collected before vitrectomy or intravitreal injection. The transcription and levels of ANRIL and other related factors were detected by RT-PCR and ELISA. Statistical Package for Social Sciences software was used for statistical analysis. Results ANRIL expression varied among different groups and body fluids. There was no difference in ANRIL expression between the NDM and DM groups, but the level of ANRIL was significantly lower in the DM group than in the NPDR and PDR group. In vitreous fluid, ANRIL expression was positively correlated with Ang II, p65 and VEGF expression in the PDR group. The expression of ANRIL in serum was not significantly correlated with age or the random blood sugar but was positively correlated with diabetic duration and HbAc1 level. Conclusions Levels of lncRNA-ANRIL are higher in DR patient and correlated with the progression of DR that may be used as an indicator to predict the development of DR. The activation of the RAS and the NF-κB pathway may be closely related to the upregulation of ANRIL. Clinical trial number ChiCTR1800017500. Registry Chinese Clinical Trial Registry. Keywords Diabetic retinopathy • Antisense non-coding RNA at the INK4 locus • Renin-angiotensin system • NF-κB pathway • Vascular endothelial growth factor This article belongs to the topical collection Eye Complications of Diabetes managed by Giuseppe Querques.

show abstract

Section: Discussionmentioning

confidence: 99%

The clinical significance of long non-coding RNA ANRIL level in diabetic retinopathy

et al. 2019

View full text Add to dashboard Cite

show abstract

Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs

Goyal

Kesharwani

Datta

2018

Cell. Mol. Life Sci.

View full text Add to dashboard Cite

Type 2 diabetes is a complex metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction. Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with this disease and its complications. Long non-coding RNAs (lncRNAs) are a novel class of functional RNAs that regulate a variety of biological processes by a diverse interplay of mechanisms including recruitment of epigenetic modifiers, transcriptional and post-transcriptional regulation, control of mRNA decay, and sequestration of transcription factors. Although the underlying causes that define the diabetic phenotype are extremely intricate, most of the studies in the last decades were mostly centered on protein-coding genes. However, current opinion in the recent past has authenticated the contributions of diverse lncRNAs as critical regulatory players during the manifestation of diabetes. The current review will highlight the importance of lncRNAs in regulating cellular processes that govern metabolic homeostasis in key metabolic tissues. A more in-depth understanding of lncRNAs may enable their exploitation as biomarkers or for therapeutic applications during diabetes and its associated complications.

show abstract

ANRIL polymorphism rs1333049, a novel genetic predictor for diabetic retinopathy complication

Cited by 2 publications

References 41 publications

The clinical significance of long non-coding RNA ANRIL level in diabetic retinopathy

The clinical significance of long non-coding RNA ANRIL level in diabetic retinopathy

Lnc-ing non-coding RNAs with metabolism and diabetes: roles of lncRNAs

Contact Info

Product

Resources

About