ANRIL: a pivotal tumor suppressor long non-coding RNA in human cancers

Zheng, Liqin; Yu, Xuezhong; Shen, Jianxiong

doi:10.1007/s13277-016-4808-5

Cited by 72 publications

(57 citation statements)

References 48 publications

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“…LncRNA ANRIL was recognized as an oncogene that was involved in a variety of diseases; however, its inhibition was proved to suppress cell proliferation, migration and invasion [8]. Activation of NF-κB, a family of transcription factors, has been revealed to take control of multiple cellular processes in diseases including inflammation, proliferation, angiogenesis, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Long non-coding RNA (lncRNA), identified as non-protein-coding RNAs which have long length with over 200 nucleotides, involves in many biological actions including cell growth and proliferation and so on [8]. Antisense non-coding RNA in the INK4 locus (ANRIL), belonging to the lncRNA family, widely exits in various human cancers, and also is regarded as a dangerous existence in breast cancer, gliomas and other several cancers proved by increasing studies [9].…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model

et al. 2016

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ObjectiveThis study aimed to explore the effects of lncRNA ANRIL on vascular endothelial growth factor (VEGF) and angiogenesis in diabetes mellitus (DM) combined with cerebral infarction (CI) through NF-κB signaling pathway.MethodsAdult male Wistar rats were randomly divided into control group and DM + CI group, and the DM + CI group were subdivided into Vector, shANRIL, PDTC, pcDNA-ANRIL, and pcDNA-ANRIL + PDTC groups. VEGF and FMS-like tyrosine kinase (FLT-1) expressions were measured by immunohistochemistry and endothelium dependent microvessel density (MVD) was detected by differentiation 31 (CD31) and para-amiuosalicylic acid (PAS) double staining. The qRT-PCR was applied to measure mRNA expressions of VEGF, FLT-1, Kinase insert domain protein receptor (FLK-1) and NF-κB, and Western blotting was conducted to detected expressions of VEGF, NF-κB and p-I?B/I?B.ResultsCompared with the control group, protein expressions of VEGF, NF-κB, p-I?B/I?B, expression of ANRIL, and mRNA expressions of VEGF, FLT-1 and NF-κB were increased in the DM + CI group. Compared with the Vector group, protein expressions of VEGF, NF-κB, p-I?B/I?B, expression of ANRIL, mRNA expressions of VEGF, FLT-1 and NF-κB, and endothelium dependent MVD were increased in the pcDNA-ANRIL group, while decreased in the shANRIL group and PDTC group. Compared with the pcDNA-ANRIL group, protein expressions of VEGF, NF-κB, p-I?B/I?B, expression of ANRIL, mRNA expressions of VEGF, FLT-1 and NF-κB, and endothelium dependent MVD were decreased in the pcDNA-ANRIL + PDTC group.ConclusionOverexpressed lncRNA ANRIL upregulates VEGF and promotes angiogenesis by activating NF-κB signaling pathway in DM + CI rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model

et al. 2016

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“…Three well-annotated lncRNAs (H19, HOTAIR and ANRIL) from lncRNADisease database were used as known OSCC-related seed lncRNAs. These three lncRNAs are associated with prognosis of OSCC and other cancers [62–64]. Subsequently, we examined whether the top lncRNAs prioritized by DisLncPri were related with OSCC patient prognosis.…”

Section: Resultsmentioning

confidence: 99%

Improved method for prioritization of disease associated lncRNAs based on ceRNA theory and functional genomics data

et al. 2016

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Although several computational models that predict disease-associated lncRNAs (long non-coding RNAs) exist, only a limited number of disease-associated lncRNAs are known. In this study, we mapped lncRNAs to their functional genomics context using competing endogenous RNAs (ceRNAs) theory. Based on the criteria that similar lncRNAs are likely involved in similar diseases, we proposed a disease lncRNA prioritization method, DisLncPri, to identify novel disease-lncRNA associations. Using a leave-one-out cross validation (LOOCV) strategy, DisLncPri achieved reliable area under curve (AUC) values of 0.89 and 0.87 for the LncRNADisease and Lnc2Cancer datasets that further improved to 0.90 and 0.89 by integrating a multiple rank fusion strategy. We found that DisLncPri had the highest rank enrichment score and AUC value in comparison to several other methods for case studies of alzheimer's disease, ovarian cancer, pancreatic cancer and gastric cancer. Several novel lncRNAs in the top ranks of these diseases were found to be newly verified by relevant databases or reported in recent studies. Prioritization of lncRNAs from a microarray (GSE53622) of oesophageal cancer patients highlighted ENSG00000226029 (top 2), a previously unidentified lncRNA as a potential prognostic biomarker. Our analysis thus indicates that DisLncPri is an excellent tool for identifying lncRNAs that could be novel biomarkers and therapeutic targets in a variety of human diseases.

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“…It is located on chromosome 9q21.3 (Table 1), is transcriptionally silenced or homozygously deleted in several human tumor types [70, 71], and is dysregulated in a number of malignancies such as breast [72], gastric [73], lung, cervical [74] and bladder cancers [75]. …”

Section: Anril (Antisense Non-coding Rna In the Ink4 Locus)mentioning

confidence: 99%

The emerging role of long non-coding RNA in gallbladder cancer pathogenesis

et al. 2017

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Gallbladder cancer (GBC) is the most common and aggressive form of biliary tract carcinoma with an alarmingly low 5-year survival rate. Despite its high mortality rate, the underlying mechanisms of GBC pathogenesis are not completely understood. Recently, from a growing volume of literature, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression and appear to play vital roles in many human cancers. To date, a number of lncRNAs have been implicated in GBC, but their potential roles in GBC have not been systematically examined. Thus, in this review, we critically discuss the emerging roles of lncRNAs in GBC, and the pathways involved. Specifically, we note that some lncRNAs show greater expression in T1 and T2 tumour stages compared to T3 and T4 tumour stages and that their dysregulation leads to alterations in cell cycle progression and can cause an increase in GBC cell proliferation and apoptosis. In addition, some lncRNAs control the epithelial-mesenchymal transition process, while others take part in the regulation of ERK/MAPK and Ras cancer-associated signalling pathways. We also present their potential utility in diagnosis, prognosis, and/or treatment of GBC. The overall goal of this review is to stimulate interest in the role of lncRNAs in GBC, which may open new avenues in the determination of GBC pathogenesis and may lead to the development of new preventive and therapeutic strategies for GBC.

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ANRIL: a pivotal tumor suppressor long non-coding RNA in human cancers

Cited by 72 publications

References 48 publications

Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model

Overexpression of lncRNA ANRIL up-regulates VEGF expression and promotes angiogenesis of diabetes mellitus combined with cerebral infarction by activating NF-κB signaling pathway in a rat model

Improved method for prioritization of disease associated lncRNAs based on ceRNA theory and functional genomics data

The emerging role of long non-coding RNA in gallbladder cancer pathogenesis

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