Another Boost for Cardiac Rehabilitation

Phillips, Robert A.

doi:10.1001/archinte.168.10.1029

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This hypothesis is supported by the strong positive association between angina, myocardial infarction, and all coronary heart disease observed in a middle-aged cohort (Singh-Manoux et al, 2003); presumably, because these subjects were younger than the age group typically studied, the likelihood of death from myocardial infarction was lower, and the potential for survival bias was minimal. On the other hand, potential drastic changes in lifestyle, cardiac rehabilitation measures, and intensive therapeutic interventions among survivors of a myocardial infarction may decrease systemic and cerebral atherosclerosis, or may improve cardiac function, cardiac output, and cerebral perfusion, and improve or prevent further cognitive damage (Petrovitch et al, 1998; Phillips, 2008). Similarly, surgical therapies for CHD may improve cardiac function, which in turn may improve cerebral perfusion, with beneficial effects on cognitive function (Petrovitch et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Coronary heart disease is associated with non-amnestic mild cognitive impairment

Roberts¹,

Knopman²,

Geda³

et al. 2010

Neurobiology of Aging

113

View full text Add to dashboard Cite

The progression of amnestic mild cognitive impairment (a-MCI) to Alzheimer's disease and hypothesized progression of non-amnestic mild cognitive impairment (na-MCI) to non-degenerative or vascular dementias suggest etiologic differences. We examined the association between coronary heart disease (CHD) and mild cognitive impairment (MCI) subtypes in a population-based cohort. Participants (n = 1969; aged 70-89 years) were evaluated using the Clinical Dementia Rating Scale, a neurological examination, and neuropsychological testing for diagnoses of normal cognition, MCI, or dementia. CHD was defined as a history of myocardial infarction, angina, angiographic coronary stenosis, or coronary revascularization and ascertained by participant interview and from medical records. CHD was significantly associated with Na-MCI (OR = 1.93; 95% CI = 1.22-3.06) but not with a-MCI (OR = 0.94; 95% CI = 0.69-1.28). In contrast, ApoE ε4 allele was significantly associated with a-MCI (OR = 1.75; 95% CI = 1.28-2.41), but not with na-MCI (OR = 1.17, 95% CI = 0.69-2.00). The association of CHD with prevalent na-MCI but not with a-MCI suggests that CHD and na-MCI may have similar underlying etiologies.

show abstract

Section: Discussionmentioning

confidence: 99%