Anorexia in the elderly

Morley, John E.; Silver, Andrew

doi:10.1016/s0197-4580(88)80004-6

Cited by 343 publications

(141 citation statements)

References 105 publications

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“…However, aging is associated with a progressive decrease in appetite and food intake [1, 2]. Although the reasons for the decline in food intake are multifactorial, it has been considered a physiological phenomenon of aging.…”

Section: Introductionmentioning

confidence: 99%

Differences in the Appetite-Stimulating Effect of Orexin, Neuropeptide Y and Ghrelin among Young, Adult and Old Rats

et al. 2005

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Aging is associated with a progressive decrease in appetite and food intake. The appetite-stimulating peptides orexin A, neuropeptide Y (NPY) and ghrelin are known to play a critical role in food intake. In this study, the stimulatory effect of intracerebroventricular administration of these peptides on food intake was compared among young (4 months old), adult (11 months old) and old (24–27 months old) male Wistar rats. A stainless steel cannula was implanted stereotactically into the left lateral ventricle. After a 7-day recovery period, different doses of orexin A (0.25–3 nmol), NPY and ghrelin (0.03–1 nmol) were injected into the left lateral ventricle without anesthesia. Food consumption was measured at 1, 2 and 4 h after injection. We also examined the plasma levels of acylated and desacyl ghrelin in young and old rats by ELISA. Intracerebroventricular administration of orexin A and NPY stimulated food intake in young and adult rats, but no effects were observed at any dose in old rats. Ghrelin increased food intake in a dose-dependent manner in all groups, and the effect of ghrelin was reduced with advancing age. Neither the acylated nor the desacyl plasma ghrelin level differed significantly between young and old rats. In conclusion, the orexigenic effect of the peptides orexin A, NPY and ghrelin decreased in old rats, and this reduction may have been responsible for the age-related decrease in food intake.

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Section: Introductionmentioning

confidence: 99%

Differences in the Appetite-Stimulating Effect of Orexin, Neuropeptide Y and Ghrelin among Young, Adult and Old Rats

et al. 2005

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“…The anorexia of aging is closely correlated with poor outcomes in older persons (32)(33)(34)(35)(36). Anorexia is a complex behavior representing the interaction of a variety of neurotransmitters that are easily perturbed by a variety of factors (37)(38)(39)(40).…”

Section: Screening Testsmentioning

confidence: 99%

Assessment of malnutrition in older persons: A focus on the mini nutritional assessment

Morley

2011

The Journal of nutrition, health and aging

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“…Infusion of glyceryl trinitrite in humans results in an increase in the size of the fundus of the stomach [87]. Older persons with early satiation sometimes improve their food intake after taking glyceryl trinitrite sublingually [88]. Nitric oxide donors are a potentially important therapeutic option for older persons suffering from early satiation.…”

Section: Nitric Oxide Donorsmentioning

confidence: 99%

Orexigenic and anabolic agents

Morley¹

2002

Clinics in Geriatric Medicine

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Anorexia in the elderly

Cited by 343 publications

References 105 publications

Differences in the Appetite-Stimulating Effect of Orexin, Neuropeptide Y and Ghrelin among Young, Adult and Old Rats

Differences in the Appetite-Stimulating Effect of Orexin, Neuropeptide Y and Ghrelin among Young, Adult and Old Rats

Assessment of malnutrition in older persons: A focus on the mini nutritional assessment

Orexigenic and anabolic agents

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