Orexigenic and anabolic agents

Morley, John E.

doi:10.1016/s0749-0690(02)00036-8

Cited by 50 publications

(14 citation statements)

References 106 publications

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“…88 Both medications are associated with significant side effects, particularly central nervous system toxicity. 88,94,95 Among anabolic agents, a 4-week randomized trial of human growth hormone in 20 undernourished elderly people demonstrated slightly faster weight gain and improved walking time in those receiving the hormone. After 4 weeks, between-group differences in weight were no longer statistically significant.…”

Section: Pharmacologic Therapy To Reverse Weight Lossmentioning

confidence: 99%

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An approach to the management of unintentional weight loss in elderly people

Alibhai

Greenwood²,

Payette³

2005

Canadian Medical Association Journal

229

143

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UNINTENTIONAL WEIGHT LOSS, or the involuntary decline in total body weight over time, is common among elderly people who live at home. Weight loss in elderly people can have a deleterious effect on the ability to function and on quality of life and is associated with an increase in mortality over a 12-month period. A variety of physical, psychological and social conditions, along with age-related changes, can lead to weight loss, but there may be no identifiable cause in up to one-quarter of patients. We review the incidence and prevalence of weight loss in elderly patients, its impact on morbidity and mortality, the common causes of unintentional weight loss and a clinical approach to diagnosis. Screening tools to detect malnutrition are highlighted, and nonpharmacologic and pharmacologic strategies to minimize or reverse weight loss in older adults are discussed.

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Section: Pharmacologic Therapy To Reverse Weight Lossmentioning

confidence: 99%

“…96 Several small clinical studies or cross-over trials of androgenic agents have not shown that they lead to weight gain. 95,97 Other pharmacologic approaches, such as anticytokine therapies, antileptin therapies and anti-inflammatory medications, are being investigated.…”

Section: Pharmacologic Therapy To Reverse Weight Lossmentioning

confidence: 99%

An approach to the management of unintentional weight loss in elderly people

Alibhai

Greenwood²,

Payette³

2005

Canadian Medical Association Journal

229

143

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“…Undernourished older adults are known to have longer periods of illness, longer hospital stays (3,4), higher infection rates (5,6), delayed wound healing, impaired cognitive function (7), reduced appetite (8), and increased mortality rates (9). Under-nutrition is a critical determinant of outcomes of hospitalization (3,10,11) and correlates with morbidity and mortality in this population (11)(12)(13).…”

mentioning

confidence: 99%

Intensive dietary intervention by a dietitian as a case manager among community dwelling older adults: The edit study

Endevelt

Lemberger

Bregman

et al. 2011

The Journal of nutrition, health and aging

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“…A number of potentially correctable and treatable causes for this condition have been identified, such as swallowing problems, poor food quality and use of drugs that suppress appetite. However, ageing has been associated with a dysregulation in appetite and a number of elderly individuals suffering from involuntary weight loss may benefit from the use of an orexigenic agent [7]. Unfortunately, at the present time, no orexigenic agent is approved by the FDA to treat involuntary weight loss that is secondary to anorexia associated with ageing.…”

Section: Involuntary Weight Loss Malnutrition and Anorexiamentioning

confidence: 99%

Drug discovery and development for ageing: opportunities and challenges

Evans

2011

Phil. Trans. R. Soc. B

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The prevention and treatment of late-life dysfunction are the goals of most geriatricians and should be the primary target for discovery and development of new medicines for elderly people. However, the development of new medicines for elderly people will face a number of challenges that are not seen for other patient populations. The burdens of multiple chronic diseases, low physiological reserve and polypharmacy must result in new clinical trials in frail older people with a high expectation of safety and efficacy. The etiology of functional limitations in elderly people is complex and often ascribed to conditions that escape the traditional definition of disease. While our society urgently needs new treatments that can reduce the burden of physical decline among older persons, guidelines on how these treatments should be developed and tested are currently lacking, in part because a consensus has not yet been achieved regarding the identifiable target diseases. New potential indications included sarcopaenia, anorexia of ageing, frailty, mobility disability and reduced functional capacity secondary to hospitalization. The challenges to conducting clinical trials in the elderly should not offset the great opportunity for the development of new medicines to prevent or reverse age-associated changes in body composition and poor functional capacity in the elderly.Keywords: sarcopaenia; functional capacity; elderly; geriatrics The sixth age shifts Into the lean and slipper'd pantaloon With spectacles on nose and pouch on side, His youthful hose well sav'd, a world too wide For his shrunk shank; and his big manly voice, Turning again toward childish treble, pipes And whistles in his sound. Last scene of all, That ends this strange eventful history, Is second childishness and mere oblivion,

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Orexigenic and anabolic agents

Cited by 50 publications

References 106 publications

An approach to the management of unintentional weight loss in elderly people

An approach to the management of unintentional weight loss in elderly people

Intensive dietary intervention by a dietitian as a case manager among community dwelling older adults: The edit study

Drug discovery and development for ageing: opportunities and challenges

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