Anomalous left coronary artery from pulmonary artery (ALCAPA) in infants: a 5-year review in a defined birth cohort

Brotherton, Helen; Philip, Roy K

doi:10.1007/s00431-007-0423-1

Cited by 51 publications

(30 citation statements)

References 12 publications

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“…Previously the incidence was reported to be 1/300000. Brotherton et al (12) reported this figure as 1/4243 in their study they performed in live newborns.…”

Section: Discussionmentioning

confidence: 84%

Yenidoğan döneminde dilate kardiyomiyopatinin nadir bir nedeni: ALCAPA sendromu

Babaoğlu¹,

Binnetoğlu²,

Altun³

et al. 2011

tpa

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“…Previously the incidence was reported to be 1/300000. Brotherton et al (12) reported this figure as 1/4243 in their study they performed in live newborns.…”

Section: Discussionmentioning

confidence: 84%

Yenidoğan döneminde dilate kardiyomiyopatinin nadir bir nedeni: ALCAPA sendromu

Babaoğlu¹,

Binnetoğlu²,

Altun³

et al. 2011

tpa

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“…This is known as myocardial steal or coronary steal. 12,13 In the infants, the chief symptom was irritability elicited by only slight effort, such as feeding, with signs of poor peripheral perfusion. These features started within 2 months of birth, coinciding with substantial reduction in pulmonary vascular resistance that resulted in coronary steal from the anterolateral aspect of the LV.…”

Section: Discussionmentioning

confidence: 99%

Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA) in an Infant - A Case Report

Jabbar

Hussain

Rima

et al. 2017

Bangladesh J Child Health

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IntroductionAnomalous origin of the left coronary artery (LCA) from the pulmonary artery (abnormal left coronary artery from pulmonary artery = ALCAPA) or BladeWhite-Garland syndrome is a rare, but serious congenital cardiac malformation. ALCAPA represents one of the most common causes of myocardial ischaemia and infarction in children. If left untreated, the mortality rate is upto 90% within the first year of life. ALCAPA accounts for 0.25-0.50% of all congenital heart diseases. 1 Although the anomalous origin of the coronary arteries that arise from the pulmonary artery was first described in1886. 2 It was not until 1933 when Bland et al 3 described the first clinical features with an autopsy finding of anomalous left coronary artery arise from the pulmonary artery (ALCAPA). The anomaly has thus been called the Bland-White-Garland Syndrome. 3,4 A coronary artery anomaly may involve an abnormal number, origin and/ or course, termination or structure of the coronary arteries. 5 The left main coronary artery normally arises from the left coronary sinus of valsalva. Instead of arising from the left aortic sinus, it may arises from the right sinus of valsalva or the proximal right coronary artery, from the non-coronary (posterior) aortic sinus,

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“…19 An embryological defect during foetal cardiac development results in the left coronary artery arising from the pulmonary artery instead of the aorta. 20 This defect may result from either abnormal septation of the conotruncus into the aorta and pulmonary artery or from persistence of the aortic buds that eventually form the coronary arteries. This anomaly is usually isolated, but has occasionally been associated with other congenital heart defects such as patent ductus arteriosus, ventricular septal defect, Tetralogy of Fallot or coarctation of aorta.…”

Section: Discussionmentioning

confidence: 99%

Anomalous Origin of Coronary Arteries: Anatomical Study and Clinical Correlates

Jayasree¹,

Ashalatha²

2016

jemds

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AIMS AND OBJECTIVESThe arterial supply of the heart is obtained by the two coronary arteries, right and left, which originate respectively from the right and left aortic sinuses of ascending aorta. Considering all congenital cardiac anomalies, the anomalous origin of coronary arteries is relatively rare, but clinically much significant when present. Anomalous coronary arteries and their clinical relevance have been reported by various workers as cases identified in cardiac patients, in cadaveric hearts and in autopsy findings. The present study aims to identify the prevalence of anomalous origin of coronary arteries and correlate them with possible clinical manifestations. STUDY SETTINGS AND DESIGNA cadaveric study was conducted in human hearts in the Department of Anatomy, Govt. Medical College, Kozhikode, Kerala. MATERIALS AND METHODSThe study was done in 60 hearts, 30 from adult cadavers and 30 from stillborn full-term foetuses. In each heart the origin of both coronary arteries were carefully studied, looking particularly for anomalies if any. The observations were recorded and photographed. RESULTS AND ANALYSISIn the present study in two hearts, both foetal coronary arteries had anomalous origin. In both the origin of right coronary artery was anomalous, one originating from left aortic sinus and the other from pulmonary trunk. In the former case, the left coronary artery had origin from pulmonary trunk. The incidence of anomalous origin of right coronary artery was 3.3% and that of left coronary artery was 1.7%. CONCLUSIONThough many patients with similar anomalies of coronary arteries may remain asymptomatic, reports from clinical studies indicate that some of them present with serious complications like attacks of syncope, pulmonary coronary steal, myocardial ischaemia and sudden cardiac death. Such cases pose diagnostic challenge to paediatricians, physicians, cardiologists and cardiothoracic surgeons. The awareness of the possibility of anomalous coronary arteries is essential for its proper recognition and diagnosis in early stages of life, which will enable timely surgical intervention and better prognosis. In this background, we discuss the clinical significance of anomalous origin of coronary arteries with review of relevant literature.

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Anomalous left coronary artery from pulmonary artery (ALCAPA) in infants: a 5-year review in a defined birth cohort

Cited by 51 publications

References 12 publications

Yenidoğan döneminde dilate kardiyomiyopatinin nadir bir nedeni: ALCAPA sendromu

Yenidoğan döneminde dilate kardiyomiyopatinin nadir bir nedeni: ALCAPA sendromu

Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA) in an Infant - A Case Report

Anomalous Origin of Coronary Arteries: Anatomical Study and Clinical Correlates

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