Anomalies of fertilization leading to triploidy

Austin, C. R.

doi:10.1002/jcp.1030560404

Cited by 48 publications

(17 citation statements)

References 30 publications

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“…Triploidy, found here with a frequency of 1.2%, can theoretically arise in various ways, but the most common are dispermy and suppression of second polar body (PB2) formation (9). In whole-mount preparations with the CF1 strain of mice, 0.6% of zygotes had three pronuclei (and were presumably triploid): dispermy and second polar body suppression occurred with equal frequency, by the criterion of presence or absence of the PB2, respectively (1).…”

Section: Discussionmentioning

confidence: 84%

Cytogenetic Analysis of the First Cleavage Division in Mouse Embryos

Donahue

1972

Proc. Natl. Acad. Sci. U.S.A.

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Chromosome counts of 338 mouse zygotes at late prophase and metaphase of the first cleavage division revealed 96.4% diploidy, 1.8% hypodiploidy, 1.2% triploidy, and 0.3% tetraploidy. One The first cleavage division is especially crucial in embryonic development. Subsequent to sperm penetration and completion of meiosis in the egg, the male-and female-derived nuclei form pronuclei, replicate their DNA, and then simultaneously enter first cleavage prophase. The two prophase chromosome groups remain physically separated until they combine to form first cleavage metaphase (1). If any one of these events is aberrant, one or both of the two daughter cells and their descendents may carry chromosomal anomalies. Abnormalities arising at later cleavage stages would presumably contribute less to the total embryo.The few chromosome studies of mammalian embryos before uterine attachment have all been conducted on blastocysts (2). In the mouse, 2.6% of day-3 blastocysts were found to be chromosomally abnormal (3). The were at late prophase, where the separateness of the male-and female-derived chromosome groups is maintained. Origin of pronucleiThroughout their lifespan, the pronuclei are of unequal size; the chromatin strands are more condensed in the smaller than in the larger pronucleus (1). Differential condensation is retained through most of first cleavage prophase (Fig. 1) and is present in about 50% of the zygotes at late prophase when chromosomes can be counted, providing the basis for identifying the origin of the different sized pronuclei. In 74 Abbreviation: HCG, human chorionic gonadotrophin.

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Section: Discussionmentioning

confidence: 84%

Cytogenetic Analysis of the First Cleavage Division in Mouse Embryos

Donahue

1972

Proc. Natl. Acad. Sci. U.S.A.

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“…This lack of data is surprising since it has been recognized that ''large/giant'' oocytes have higher chances of aneuploidy (3,6). Taken together, these facts provide the rationale for investigating: 1) whether a cohort containing a giant oocyte is associated with adverse outcomes compared with a cohort consisting exclusively of normal-size oocytes; and 2) if occurrence of a giant oocyte in one cohort is reflective of aberrations in oocytes in another that may give rise to embryos exhibiting abnormal development.…”

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confidence: 90%

A giant oocyte in a cohort of retrieved oocytes: does it have any effect on the in vitro fertilization cycle outcome?

Machtinger

Politch

Hornstein

et al. 2011

Fertility and Sterility

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“…In any case, these are factors which can bring about fusion of two germ cells or suppress the cytokinesis of a germ cell (Wilson, 1928;Austin, 1960Austin, , 1961. In addition to these, factors which induce biovular follicles are also conceivable (Hartman, 1926;Austin, 1961). Summary.…”

Section: Methodsmentioning

confidence: 99%

Active development in preimplantation stages of giant digynic triploids in the Chinese hamster.

Funaki

1981

Proceedings of the Japan Academy. Ser. B: Physical and Biologic

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Anomalies of fertilization leading to triploidy

Cited by 48 publications

References 30 publications

Cytogenetic Analysis of the First Cleavage Division in Mouse Embryos

Cytogenetic Analysis of the First Cleavage Division in Mouse Embryos

A giant oocyte in a cohort of retrieved oocytes: does it have any effect on the in vitro fertilization cycle outcome?

Active development in preimplantation stages of giant digynic triploids in the Chinese hamster.

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