Active development in preimplantation stages of giant digynic triploids in the Chinese hamster.

Funaki, Kenji

doi:10.2183/pjab.57.18

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…In both the Chinese hamster (8,9) and the human (6), giant zygotes have been reported to develop to the blastocyst stage. However, cytogenetic analysis in human giant oocytes has revealed that the unfertilized giant eggs were diploid and the zygotes were genetically abnormal even when they exhibited two pronuclei and two polar bodies at the fertilization check (3,7).…”

mentioning

confidence: 99%

A giant oocyte in a cohort of retrieved oocytes: does it have any effect on the in vitro fertilization cycle outcome?

Machtinger

Politch

Hornstein

et al. 2011

Fertility and Sterility

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confidence: 99%

A giant oocyte in a cohort of retrieved oocytes: does it have any effect on the in vitro fertilization cycle outcome?

Machtinger

Politch

Hornstein

et al. 2011

Fertility and Sterility

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“…4). The polyploidy (8n) reported by Endo and Ingalls (1968) and triploidy described by Funaki (1981), Funaki and Mikamo (1980) and Takagi and Sasaki (1976), were not found. Mixoploidy involving tetraploidy (4n) from embryos of NOD-DM mouse were observed as roughly the same as those of NOD-N and ICR mice.…”

Section: Resultsmentioning

confidence: 89%

Chromosome Analysis in Preimplantation Stage Embryos of Non‐Obese Diabetic (NOD) Mice

Tatewaki

Otani

Tanaka

et al. 1989

Congenital Anomalies

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Congenital malformations such as exencephaly occur at a high incidence in non-obese diabetic (NOD) mouse embryos (Otani et al., 1987a). Using in vitro culture and embryo transfer, genetic predispositions as well as environmental factors were suggested to be the causes (Tatewaki et al., 1987).Chromosomes of preimplantation embryos, cultured to transfer mutually between non-obese diabetic (NOD) and ICR mice, were analyzed as a clue to elucidate the cause of developmental anomalies. Among these preimplantation embryos, aneuploidy, mixoploidy and structural anomalies were found, but in incidence of chromosomal anomalies there was no significant difference, statistically, between preimplantation embryos from diabetic mothers and those from nondiabetic mothers. These findings are considered to show that no increase in developmental abnormality in chromosomes occurs during the preimplantation stage.

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“…We believe that this is a possible explanation since we have observed that diandric triploid embryos produced by nuclear manipulation divide during the preimplantation period a t the same rate as diploid controls and, moreover, that they achieve the blastocyst stage at the same time (Henery and Kaufman, 1992a). While some authorities have reported that digynic triploid mouse embryos develop at the same rate as controls (e.g., Niemerko, 1975;Opas, 1974;Funaki, 1981), others have reported that they have a slower rate of cleavage (Takagi and Sasaki, 1976;Beatty and Fischberg, 1951). To date, however, no detailed analysis has been made that would allow a comparison to be made between the cleavage rate of these two classes of triploids.…”

Section: Introductionmentioning

confidence: 72%

“…Digynic triploidy occurs spontaneously in many mammalian species, and usually results from an error of cytokinesis that may occur during either the first or the second meiotic division of the oocyte. More rarely, it may result from the fertilisation of a "giant" diploid oocyte by a normal haploid sperm (Funaki and Mikamo, 1980;Funaki, 1981).…”

Section: Introductionmentioning

confidence: 99%

The cleavage rate of digynic triploid mouse embryos during the preimplantation period

Henery

Kaufman

1993

Molecular Reproduction Devel

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Triploidy is a lethal condition in mammals, with most dying at some stage between implantation and term. In humans, however, a very small proportion of triploids are liveborn but display a wide range of congenital abnormalities. In particular, the placentas of human diandric triploid embryos consistently display "partial" hydatidiform molar degeneration, while those of digynic triploids generally do not show these histopathological features. In mice, the postimplantation development of diandric and digynic triploid embryos also differs. While both classes are capable of developing to the forelimb bud stage, no specific degenerative features of their placentas have been reported. Diandric triploid mouse embryos are morphologically normal while digynic triploid mouse embryos consistently display neural tube and occasionally cardiac abnormalities. Previously it was shown that the preimplantation development of micromanipulated diandric triploid mouse embryos was similar to developmentally matched diploid control embryos. In this study, the preimplantation development of micromanipulated digynic triploid mouse embryos is analysed and compared with that of diandric triploid mouse embryos in order to determine whether there is any difference in cleavage rate between these two classes of triploids. Standard micromanipulatory procedures were used to insert a female or a male pronucleus into a recipient diploid 1-cell stage embryo. The karyoplast was fused to the cytoplasm of the embryo by electrofusion. These tripronucleate 1-cell stage embryos were then transferred to pseudopregnant recipients and, at specific times after the HCG injection to induce ovulation, the embryos were recovered and total cell counts made. These results were plotted and regression lines drawn.(ABSTRACT TRUNCATED AT 250 WORDS)

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Active development in preimplantation stages of giant digynic triploids in the Chinese hamster.

Cited by 9 publications

References 7 publications

A giant oocyte in a cohort of retrieved oocytes: does it have any effect on the in vitro fertilization cycle outcome?

A giant oocyte in a cohort of retrieved oocytes: does it have any effect on the in vitro fertilization cycle outcome?

Chromosome Analysis in Preimplantation Stage Embryos of Non‐Obese Diabetic (NOD) Mice

The cleavage rate of digynic triploid mouse embryos during the preimplantation period

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