Anodyne activities of New Tetrazole derivatives from Triazine

Abstract

<jats:p>The creation of novel drugs containing a tetrazole ring as a structural fragment has contributed considerably to the outstanding achievements of the pharmaceutical chemistry in the last decade. Tetrazoles are the heterocyclic compounds having diverse biological activities such as analgesic, antiinflammation, antimicrobial, anticancer, antidiabetic, etc., and an impending source in biosciences. In this paper, the authors describe the synthesis of novel tetrazoles from N, N-( 6-Phenyl-1,3,5-triazine-2,4-diyl) dibenzamide (PTDDB) and 2-phenyl-4, 6-di(2H-tetrazole-2-yl)-1,3,5-triazine(5a-i) were prepared per the proposed scheme. A new class of tetrazole heterocycles were synthesised and characterised. I n vivo analysis was carried out on the analgesic property of synthesised tetrazole derivatives (5a, 5b, 5c). Characterisation studies such as IR, 1H NMR, 13C NMR, Mass and elemental analysis were performed for the synthesised tetrazole derivatives. Some of the tetrazole derivatives 5a, 5b, and 5c were tested for anodyne activity using morphine as the standard drug. The data reveals that all the three compounds 5a, 5b and 5c taken for the study show analgesic activity by hot plate method and tail flick methods. Among tested compounds, compound 5c is found to have potent analgesic (anodyne) activity. The results of the study indicate that the sample taken for the study show fairly good business using morphine as the standard drug.</jats:p>

Synthesis of a novel fused thieno‐pyrimidine with tetrazole analogs

“…To monitor the reactions, we employed thin-layer chromatography (TLC) on silica gel and glass columns packed with silica gel of various mesh sizes for column chromatography. On Jeol 400 MHz spectrometers, 1 H and 13 C NMR investigations in CDCl 3 and DMSO-d 6 were carried out with TMS acting as the internal standard. Utilizing KBr pellets, FT-IR spectra were collected.…”

“…Many investigations have focused on discovering novel physiologically active compounds using tetrazole as a core moiety [8,9]. Tetrazole-based drugs are being investigated in the pharmaceutical industries due to their diverse medicinal importance: antiamoebic, anti-inflammatory, antihypertensive, antiallergic, antimalarial, antitubercular, antibacterial, antiulcer, antifungal, antiviral, and antiangiogenesis agents [8][9][10][11][12][13][14][15][16][17][18]. Furthermore, tetrazole-based medications are particularly efficient in the treatment of dead illnesses such as cancer and AIDS [18][19][20].…”

Crystal structure and Hirshfeld surface analysis of 1-(2-fluorophenyl)-1H-tetrazole-5(4H)-thione

“…Up to know, most synthetic protocols comprise the cycloaddition of nitriles, thiocyanates or isothiocyanates with an azide moiety, under different conditions. Tetrazole derivatives have found a broad range of applications in medicinal chemistry (Wang et al, 2019;Gao et al, 2019;Arulmozhi et al, 2017), coordination chemistry (Askerov et al, 2018;Askerov et al, 2019a,b;Aromí et al, 2011) and material science (Frija et al, 2010;Lv et al, 2006). Numerous tetrazole-based synthetic compounds such as tomelukast, cefazolin, losartan, valsartan and alfentanil have already been used in medicinal practice.…”

Novel dinuclear Ni (II) Schiff base complexes induced noncovalent exchanges: Crystal structure investigation, electrochemical assessment, Hirshfeld surface analysis and SARS‐CoV‐2 docking study

“…Also, the synthesis of Ni (II) complexes and the investigation of their biological activity in recent years have been widely noticed by chemists. [24][25][26][27][28][29][30][31][32][33][34][35][36] In 2019, Co (II), Ni (II), and Cu (II) metal complexes of Schiff base ligand derived from 2-hydroxy-4-methoxybenzaldehyde and 2-amino-6-methylbenzothiazole were prepared and characterized. Also, in this article, the ligand and metal complexes were analyzed using DFT.…”