“…The clinical manifestations of early secondary syphilis include small papular, follicular, vesicular, corymbiform, psoriasiform rashes, while late secondary syphilis presents as nodular, annular, pustular, frambesiform, nodular-ulcerative form. 1,2 Annular secondary syphilis is mainly located at the mucocutaneous junction of the nasal alae and the oral commissure with the prevalence of 5.7-13.6%. 1 Therefore, the syphilitic lesion in our case is rare.…”