“…Secondary syphilis skin manifestations vary but commonly include macules, maculopapular rash, papules and plaques. 1 Lesions can be generalized or confined, and they can mimic the lesions of many diseases, such as pityriasis rosea, 2 verruca vulgaris, 3 annular lichen planus, 4 which are referred to as the Great Imitator or Great Mimicker. 5 A syphilis diagnosis is often based on a suggestive clinical history and supportive laboratory 6 (that is, serodiagnosis) tests, especially, secondary syphilis often causes rash on palms and soles.…”