Annual screening detects celiac disease in children with type 1 diabetes

Abstract

Our study confirmed the low prevalence (0.7%) of diagnosed symptomatic CD at the time of clinical diagnosis but document by screening an increasing prevalence of silent CD during a 5-yr follow-up to reach an overall prevalence of 10%. We suggest that children with T1DM should be screened for CD at the onset of T1DM and annually for a minimum of at least 2 yr. HLA genotypes among T1DM patients developing CD were not different from those among patients with T1DM alone.

Dietary gluten and the development of celiac disease and type 1 diabetes

“…Thus, the important information derived from the Pham-Short et al 29 review is that, since 55% of cases were diagnosed within 2 years and 79% within 5 years from diabetes onset, screening for CD should be considered at diabetes diagnosis and again within 2 and 5 years after diagnosis. This datum is also confirmed by Larsson et al, 25 who suggested a screening for CD at the onset of T1DM, and annually for a minimum of at least 2 years.…”

“…23 The previous literature reported contradictory results between the sexes for the prevalence of CD in T1DM. The prevalence was higher in females in some studies, 13,24 higher in males in others, 25,26 and yet other studies reported no difference. 27,28 However, a meta-analysis published in 2014 described no sex predominance in the prevalence of CD in T1DM.…”

Autoimmune Disorders Associated to Type 1 Diabetes Mellitus in Children and Adolescents

“…As regards timing of screening, it has been reported that the serological screening of celiac disease allows diagnosing 1% of patients with celiac disease. The frequency of diagnoses increases to 5% when screening is performed in the next 5 years after diabetes diagnosis (Larsson et al, 2008). It has been reported that up to 85% of cases of celiac disease is diagnosed 2-5 years after type 1 diabetes clinical onset (Saukkonen et al, 1996).…”

“…diarrhea and abdominal pain, are reported in 28% and 14% of patients, respectively (Bhadada et al, 2011). Symptoms attributable to celiac disease are more common in children than in adolescents or adults (Larsson et al, 2008). Type 1 diabetes precedes celiac disease diagnosis (Holmes, 2001); in a small proportion (up to 25%) of cases type 1 diabetes develops in already diagnosed celiac patients (Valerio et al, 2002).…”

Celiac disease and diabetes mellitus type 1.

“…However, the latter is often latent, Larsson et al suggest that T1DM patients should be screened annually 69 .…”