SUMMARY: We study the interannual and seasonal variability in the Mediterranean Sea over the period by comparing a numerical simulation (the 1/4º ORCA-R025 G70 model run, 'ORCA' hereafter) with altimetry and the ME-DAR temperature and salinity database. The model is forced by the ERA40 atmospheric forcing and has a salinity restoring term applied at surface. Comparing temperature between ORCA and MEDAR shows good interannual variability agreement (correlations of ~0.8 in the western Mediterranean and ~0.5 in the eastern Mediterranean) at surface layers (0-150 m), but slightly higher mean values in the model (0.08-0.16°C). The salinity analysis shows that the surface salinity restoring term has obliterated most of the interannual variability. Mean surface salinities are slightly lower in the model (~0.3), replicated in deeper layers to a lesser degree, and could mean that the restoring term applies insufficient evaporation to compensate for a weak atmospheric forcing (ERA40) water loss flux. The sea level analysis comparing sea surface height (SSH) and steric height from ORCA and sea level anomalies from altimetry (1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004) shows good correlations (~0.8) in the interannual variability and annual cycle. However, the model's SSH overestimates (~15 mm/yr) observed positive altimetric trends (~3-4 mm/yr). In an attempt to identify the source of this overestimation, a water budget calculation was performed between the horizontal and vertical water fluxes in the Mediterranean Sea. Horizontal transport through the main straits shows appropriate values when compared to observations. Thus, the cause of the exaggerated SSH trend is probably a water flux imbalance. By improving surface salinity restoring and atmospheric forcing, the ORCA simulations can provide very promising tools for studies of interannual variability in the Mediterranean Sea.Keywords: sea level, altimetry, temperature, salinity, modelling, Mediterranean Sea. RESUMEN: Evaluación de un retroanálisis de 44 años para el mar Mediterráneo: comparación con altimetría y observaciones in situ. -Estudiamos la variabilidad estacional e interanual en el mar Mediterráneo durante el periodo 1958-2004, comparando una simulación numérica (la simulación de 1/4º ORCA-R025 G70, 'ORCA' de ahora en adelante) con datos de altimetría, y temperatura y salinidad (MEDAR). El modelo utiliza el forzamiento atmosférico ERA40 y tiene aplicado un término de relajación a la salinidad en superficie. La comparación de temperatura entre ORCA y MEDAR muestra un buen acuerdo de la variabilidad interanual (correlación ~0.8 en el Mediterráneo Occidental (WMED), ~0.5 en el Mediterráneo Oriental (EMED)) en las capas superficiales (0-150 m), pero con valores medios ligeramente superiores en el modelo (0.08-0.16ºC). El análisis de salinidad muestra que la mayor parte de la variabilidad en superficie ha sido destruida por el término de relajación. Las salinidades medias en superficie son ligeramente inferiores en el modelo (~0.3), lo ...