Anna Akhmatova

Brown, Clarence; Hemschemeyer, Judith; Akhmatova, Anna; Reeder, Roberta

doi:10.2307/3851781

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Lateral Segregation: Lipid Domains In Supported Bilayers1

Introduction1

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2001

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Cited by 2 publications

(2 citation statements)

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“…This phase separation is of particular interest since it is suspected to give rise to biologically functional domains in biological membranes [28]. Such domains are also referred to as rafts [29] or as detergent-resistant membranes (DRMs) [30], because they are insoluble in non-ionic detergent in the cold. Isolated DRMs have been imaged by Le Grimellec and coworkers [31].…”

Section: Lateral Segregation: Lipid Domains In Supported Bilayersmentioning

confidence: 99%

Imaging domains in model membranes with atomic force microscopy

Rinia

Kruijff²

2001

FEBS Letters

119

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Section: Lateral Segregation: Lipid Domains In Supported Bilayersmentioning

confidence: 99%

Imaging domains in model membranes with atomic force microscopy

Rinia

Kruijff²

2001

FEBS Letters

119

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“…Especially domains that consist of sphingolipids and cholesterol have received much attention lately [3^5]. Such domains are usually referred to as rafts [6] and they are believed to correspond to parts of biological membranes that are resistant to non-ionic detergent in the cold [7]. Detergent resistant membranes (DRMs) [8,9] have indeed been found to be enriched in sphingolipids and cholesterol.…”

Section: Introductionmentioning

confidence: 99%

Visualizing detergent resistant domains in model membranes with atomic force microscopy

et al. 2001

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Evidence is accumulating that in cell membranes microdomains exist, also referred to as rafts or detergent resistant membranes. In this study, atomic force microscopy is used to study supported lipid bilayers, consisting of a fluid phosphatidylcholine, sphingomyelin and cholesterol. Domains were visualized of which the morphology and size depended on the cholesterol concentration. The presence of cholesterol was found to induce bilayer coupling. At 30 mol% cholesterol, a change in percolation phase was observed, and at 50 mol%, when both fluid lipids and solid lipids are saturated with cholesterol, phase separation was still observed. In addition, we were able to directly visualize the resistance of domains against non-ionic detergent. ß

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Anna Akhmatova

Cited by 2 publications

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Imaging domains in model membranes with atomic force microscopy

Imaging domains in model membranes with atomic force microscopy

Visualizing detergent resistant domains in model membranes with atomic force microscopy

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