Ankle-Brachial Pressure Index Estimated by Laser Doppler in Patients Suffering from Peripheral Arterial Obstructive Disease

Ludyga, Tomasz; Kuczmik, Wacław; Kazibudzki, Marek; Nowakowski, Przemysław; Orawczyk, Tomasz; Glanowski, Michał; Kucharzewski, Marcin; Ziaja, Damion; Szaniewski, Krzysztof; Ziaja, Krzysztof

doi:10.1016/j.avsg.2006.08.004

Cited by 15 publications

(15 citation statements)

References 23 publications

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“…A laser Doppler probe placed on the dorsum of the foot to detect flow was used for ABI measurements in 1 study. 170 The mean difference compared with Doppler was negligible, but agreement and reproducibility were not reported.…”

Section: Methods Of Pressure Measurementmentioning

confidence: 99%

Measurement and Interpretation of the Ankle-Brachial Index

Aboyans

Criqui²,

Ábrahám³

et al. 2012

Circulation

1,337

827

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T he ankle-brachial index (ABI) is the ratio of the systolic blood pressure (SBP) measured at the ankle to that measured at the brachial artery. Originally described by Winsor 1 in 1950, this index was initially proposed for the noninvasive diagnosis of lower-extremity peripheral artery disease (PAD). 2,3 Later, it was shown that the ABI is an indicator of atherosclerosis at other vascular sites and can serve as a prognostic marker for cardiovascular events and functional impairment, even in the absence of symptoms of PAD. 4 -6 Rationale for Standardization of the ABIThe current lack of standards for measurement and calculation of the ABI leads to discrepant results with significant impact from clinical, public health, and economic standpoints. Indeed, the estimated prevalence of PAD may vary substantially according to the mode of ABI calculation. [7][8][9] In a review of 100 randomly selected reports using the ABI, multiple variations in technique were identified, including the position of the patient during measurement, the sizes of the arm and leg cuffs, the location of the cuff on the extremity, the method of pulse detection over the brachial artery and at the ankles, whether the arm and ankle pressures were measured bilaterally, which ankle pulses were used, and whether a single or replicate measures were obtained. 10 There is controversy about what ABI threshold should be used to diagnose PAD. The ABI threshold most commonly used is Յ0.90 based on studies reporting Ͼ90% sensitivity and specificity to detect PAD compared with angiography. 2,3 These studies were limited in that they included mostly older white men with PAD or who were at high risk for PAD and compared them with a younger healthy group. A recent metaanalysis of 8 studies of diverse populations, including diabetic patients, confirmed a high specificity but lower sensitivity (at best Ͻ80%) than that reported in earlier studies. 11 Similar to other vascular markers such as carotid intimamedia thickness 12 or coronary artery calcium score, 13 standardization of the techniques used to measure the ABI and the calculation and interpretation of its values is necessary. Aims and ScopeThe goals for this document are to provide a comprehensive review of the relevant literature on the measurement of the The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on September 10, 2012. A copy of the document is available at http://my.americanheart.org/statements by selecting either the "By Topic" link or the "By Publication Date" link. To purchase additional repri...

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Section: Methods Of Pressure Measurementmentioning

confidence: 99%

Measurement and Interpretation of the Ankle-Brachial Index

Aboyans

Criqui²,

Ábrahám³

et al. 2012

Circulation

1,337

827

View full text Add to dashboard Cite

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“…As shown in Figure 2D, both C57BL6 and ApoE demand ischemic mice developed significant hyperemia consistent with demand ischemia and a physiologic response associated with symptomatic intermittent claudication in humans(33, 34). …”

Section: Discussionmentioning

confidence: 80%

“…This is in contrast to the findings of other investigators who demonstrated marked dysfunction and ongoing hypoperfusion in ApoE mice compared to wild type controls (32). Those investigators studied young male mice, however claudication in humans is usually found in aged individuals(31, 33), thus these experiments were done in aged mice. The absence of differences between the wild type and ApoE mice after femoral artery ligation could be related to the age and/or gender of the mice used in these studies in this report.…”

Section: Discussionmentioning

confidence: 99%

Divergent systemic and local inflammatory response to hind limb demand ischemia in wild-type and ApoE–/– mice

Crawford

Albadawi

Robaldo

et al. 2013

Journal of Surgical Research

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Introduction Studies were designed to determine whether the ApoE−/− phenotype modulates the local skeletal muscle and systemic inflammatory (plasma) responses to lower extremity demand ischemia. The ApoE−/− phenotype is an experimental model for atherosclerosis in humans. Methods Aged female ApoE −/− and C57BL6 mice underwent femoral artery ligation, then divided into sedentary and demand ischemia (exercise) groups on day 14. Baseline and post exercise limb perfusion and hind limb function were assessed. On day 14, animals in the demand ischemia group underwent daily treadmill exercise through day 28. Sedentary mice were not exercised. On day 28, plasma and skeletal muscle from ischemic limbs were harvested from sedentary and exercised mice. Muscle was assayed for angiogenic and pro-inflammatory proteins, markers of skeletal muscle regeneration, and evidence of skeletal muscle fiber maturation. Results Hind limb ischemia was similar in ApoE −/− and C57 mice prior to the onset of exercise. Under sedentary conditions, plasma VEGF, IL-6, but not KC or MIP-2 were higher in ApoE (P<0.0001). Following exercise, plasma levels of VEGF, KC and MIP-2, but not IL-6 were lower in ApoE (P<0.004). The cytokines KC and MIP-2 in muscle was greater in exercised ApoE−/− mice as compared to C57BL6 mice (p=0.01). Increased PAR activity, and mature muscle regeneration was associated with demand ischemia in the C57BL6 mice as compared to the ApoE −/− mice (p=0.01). Conclusion Demand limb ischemia in the ApoE−/− phenotype exacerbated the expression of select systemic cytokines in plasma and blunted indices of muscle regeneration.

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“…Ludyga et al [39], evaluated the ABI in patients with PAD including symptomatic CLI, compared the ABI obtained with traditional Doppler and sphyngomamometer versus laser Doppler. The 30 patients, 21 men and 9 women, underwent the treadmill test, and pain-free walking distances were measured with both Doppler ultrasound (ABI-Doppler) and laser Doppler (ABI-laser Doppler).…”

mentioning

confidence: 99%