Contemporary assessment of foot perfusion in patients with critical limb ischemia

Benitez, Erik; Sumpio, Brandon J.; Chin, Jason A.; Sumpio, Bauer E.

doi:10.1053/j.semvascsurg.2014.12.001

Cited by 43 publications

(30 citation statements)

References 37 publications

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“…19 The PVR has since become an indispensable tool in the noninvasive vascular laboratory for obtaining information regarding a patient's perfusion in the lower extremities.…”

Section: Resultsmentioning

confidence: 99%

Pulse volume recording for peripheral vascular disease diagnosis in diabetes patients

Benitez¹,

Sumpio²

2015

JVD

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“…19 The PVR has since become an indispensable tool in the noninvasive vascular laboratory for obtaining information regarding a patient's perfusion in the lower extremities.…”

Section: Resultsmentioning

confidence: 99%

Pulse volume recording for peripheral vascular disease diagnosis in diabetes patients

Benitez¹,

Sumpio²

2015

JVD

Self Cite

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“…It is a reliable method for microcirculation research [32]. In previous studies, LPI was used for the clinical detection of local tissue perfusion, such as foot perfusion [33], cerebral blood flow [34], and skin perfusion [35]. In the present study, LPI was combined with a microscope to detect the changes of blood perfusion in the MSAs of living DS rats and was a useful device to observe the function and blood perfusion of small arteries in vivo.…”

Section: Discussionmentioning

confidence: 99%

High Sodium Intake Impairs Small Artery Vasoreactivity in vivo in Dahl Salt-Sensitive Rats

Wang

Chen

et al. 2019

J Vasc Res

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The effects of high sodium intake on the functionality of resistance arteries have been repeatedly studied in vitro, but no study has focused on salt-sensitive hypertension in vivo. We studied the in vivo reactivity of mesenteric small arteries (MSAs) to vasoactive agents in Dahl salt-sensitive (DS) rats with various sodium diets. Twenty-four male DS rats were randomized into 3 groups: LS (0.3% NaCl diet), NS (0.6% NaCl diet), and HS (8% NaCl diet). After a 12-week intervention, the diameter changes of the MSAs after noradrenaline (NA) and acetylcholine (ACh) exposure were detected by a microscope, and changes in blood perfusion through the MSAs were measured by full-field laser perfusion imaging. HS enhanced the constrictive response of the MSAs to NA and attenuated the relaxing response to ACh. Low sodium intake reduced the response of the MSAs to NA and promoted ACh-induced vasodilatation. HS also aggravated NA-induced blood perfusion reduction and impaired ACh-induced hyperperfusion of the MSAs. Pathologically, HS was associated with arteriolar structural damage and fibrosis of the MSAs. We conclude that sodium intake affects the responsiveness of the MSAs to vasoactive agents in DS rats and might play important roles in modulating blood pressure in hypertensive individuals.

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“…Paracrine action and anti-in ammation effects have also recently been demonstrated as important roles in SCT [45][46][47]. Hemodynamic parameters like ABI and TCPO2 were commonly used in evaluating lower limb perfusion and regarded as effective noninvasive modalities correlating well with clinical severity parameters after revascularization interventions [48]. Considering that the functional mechanism of cell therapy is totally different from revascularization modalities, application of conventional hemodynamic parameters, especially ABI which re ects the blood ow in relatively large size of artery, in predicting the clinical trend after SCT remains to be studied [26,37,38].…”

Section: Discussionmentioning

confidence: 99%

Autologous Peripheral Blood-derived Stem Cells Transplantation for Treatment of no-option Angiitis-induced Critical Limb Ischemia: 10-year Management Experience

Fang

Jiang

Fang

et al. 2020

Preprint

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Background: Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Additionally, a randomized controlled trial (RCT) recently conducted by us suggested that peripheral blood-derived purified CD34+ cells (PCCs) were not inferior to non-purified peripheral blood mononuclear cells (PBMNCs) at limb salvage in treatment of NO-AICLI. However, most of these clinical trials whether RCT or single-arm studies were characterized with a small sample size and absence of long-term outcomes. Methods: To analyze long-term clinical outcomes of PBDSCs transplantation for NO-AICLI, we reviewed clinical data of patients with NO-AICLI receiving PBDSCs transplantation at our center during the past decade. Meanwhile, we first compared the long-term safety and efficacy of intramuscular transplantation of PCCs versus PBMNCs in a sizable number of patients with NO-AICLI.Results: From May 2009 to December 2019, a total of 160 patients with NO-AICLI patients were treated by PBDSCs transplantation (82 with PCCs, 78 with PBMNCs) at our center. Baseline characteristics between two groups were similar. Up to June 2020, the mean follow-up period was 46.6±35.3 months. No critical adverse events were observed in either group. There was one death during the follow-up period. A total of eight major amputations occurred. The cumulative major amputation-free survival (MAFS) rate at 5 years after PBDSCs transplantation was 94.4%, without difference between two groups (P=.855). Wound healing, rest pain, pain-free walking time, ankle-brachial index, transcutaneous oxygen pressure, and quality of life (QoL) also significantly improved after PBDSCs transplantation. Conclusions: Autologous PBDSCs intramuscular transplantation could significantly decrease the major amputation rates and improve the QoL in patients with NO-AICLI. Long-term observation of a large sample of patients confirmed that the clinical benefits of PBDSCs transplantation were durable, without difference between the PCCs and PBMNCs groups.

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Contemporary assessment of foot perfusion in patients with critical limb ischemia

Cited by 43 publications

References 37 publications

Pulse volume recording for peripheral vascular disease diagnosis in diabetes patients

Pulse volume recording for peripheral vascular disease diagnosis in diabetes patients

High Sodium Intake Impairs Small Artery Vasoreactivity in vivo in Dahl Salt-Sensitive Rats

Autologous Peripheral Blood-derived Stem Cells Transplantation for Treatment of no-option Angiitis-induced Critical Limb Ischemia: 10-year Management Experience

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