Ankle brachial index most important to identify polyvascular disease in patients with non-ST elevation or ST-elevation myocardial infarction

Jönelid, Birgitta; Johnston, Nina; Berglund, Lars; Andrén, Bertil; Kragsterman, Björn; Christersson, Christina

doi:10.1016/j.ejim.2015.12.016

Cited by 21 publications

(15 citation statements)

References 25 publications

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“…The increase in all-cause mortality, AMI, and IS risk conferred by low ABI in asymptomatic participants with previous CVD and/or diabetes is compatible with low ABI being a surrogate of vascular damage in the context of polyvascular disease; indeed, low ABI has been reported to be useful in identifying this condition [35,36]. In addition to corroborating these findings, our results quantify the risk increase contributed by polyvascular damage, and are in line with previous recommendations to use ABI for the detection of asymptomatic PAD in persons with previous CVD and diabetes, both in isolation or when coexistent [37].…”

Section: Discussionmentioning

confidence: 99%

Role of Low Ankle–Brachial Index in Cardiovascular and Mortality Risk Compared with Major Risk Conditions

Alves-Cabratosa

García-Gil

Comas-Cufí

et al. 2019

JCM

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Cardiovascular prevention is of particular interest in persons with asymptomatic peripheral arterial disease. We aimed to quantify its association with mortality and cardiovascular outcomes, compared to other indicators of high risk. We performed a retrospective cohort study using the Database of the Catalan primary care system (SIDIAPQ), for 2006–2015, including 35–85-year-old patients with an ankle–brachial index (ABI) measurement, classified according to the presence of diabetes, cardiovascular disease, and low ABI (<0.9). We calculated the incidences and hazard ratios (HRs) for all-cause mortality, acute myocardial infarction, and ischemic stroke. During a median follow-up of 5.9 years, we analyzed 58,118 persons. The mean (SD) age was 66.6 (10.7) years and 53.4% were men. Compared to the reference group with no diabetes, no previous cardiovascular disease, and normal ankle–brachial index, the HR for all-cause mortality was 1.42 (1.25–1.63) in the group with low ABI, 1.35 (1.26–1.45) in those with diabetes, 1.50 (1.34–1.69) in those with previous cardiovascular disease, and 1.84 (1.68–2.01) in those with low ABI and diabetes. In conclusion, participants with low ABI showed increased mortality, acute myocardial infarction, and ischemic stroke incidence in all the subgroups. Patients with low ankle–brachial index plus diabetes presented increased mortality, acute myocardial infarction, and ischemic stroke risk, all at rates similar to those with previous cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Role of Low Ankle–Brachial Index in Cardiovascular and Mortality Risk Compared with Major Risk Conditions

Alves-Cabratosa

García-Gil

Comas-Cufí

et al. 2019

JCM

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“…Deficiencies in provision of information can be even more problematic. In a recently published article, Jönelid et al ( 21 ) investigated usefulness of the ankle–brachial index for identifying polyvascular disease. Although they reported a specificity of 92.4% and a PPV of 68.4%, they did not provide results concerning either sensitivity or NPV.…”

Section: The Importance Of Full Disclosure Of Information In Researchmentioning

confidence: 99%

Sensitivity, Specificity, and Predictive Values: Foundations, Pliabilities, and Pitfalls in Research and Practice

Trevethan

2017

Front. Public Health

1,117

855

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Within the context of screening tests, it is important to avoid misconceptions about sensitivity, specificity, and predictive values. In this article, therefore, foundations are first established concerning these metrics along with the first of several aspects of pliability that should be recognized in relation to those metrics. Clarification is then provided about the definitions of sensitivity, specificity, and predictive values and why researchers and clinicians can misunderstand and misrepresent them. Arguments are made that sensitivity and specificity should usually be applied only in the context of describing a screening test’s attributes relative to a reference standard; that predictive values are more appropriate and informative in actual screening contexts, but that sensitivity and specificity can be used for screening decisions about individual people if they are extremely high; that predictive values need not always be high and might be used to advantage by adjusting the sensitivity and specificity of screening tests; that, in screening contexts, researchers should provide information about all four metrics and how they were derived; and that, where necessary, consumers of health research should have the skills to interpret those metrics effectively for maximum benefit to clients and the healthcare system.

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“…People with diabetes have a higher risk of developing stroke, myocardial infarction (MI), and claudicatio intermittens (Recarti, Sep, Stehouwer, & Unger, ). The signs of atherosclerosis are also widespread in people suffering from diabetes (Jonelid et al, ). Morphologically, people with type 2 diabetes have reported to develop more plaques and also a higher occurrence of plaque rupture, in contrast with people without diabetes (Cheng et al, ; Meier & Thalmann, ).…”

Section: Inflammation In Heart Diseasesmentioning

confidence: 99%

The multifaceted link between inflammation and human diseases

Rajendran

Chen

Chen³

et al. 2018

Journal Cellular Physiology

108

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Increasing reports on epidemiological, diagnostic, and clinical studies suggest that dysfunction of the inflammatory reaction results in chronic illnesses such as cancer, arthritis, arteriosclerosis, neurological disorders, liver diseases, and renal disorders. Chronic inflammation might progress if injurious agent persists; however, more typically than not, the response is chronic from the start. Distinct to most changes in acute inflammation, chronic inflammation is characterized by the infiltration of damaged tissue by mononuclear cells like macrophages, lymphocytes, and plasma cells, in addition to tissue destruction and attempts to repair. Phagocytes are the key players in the chronic inflammatory response. However, the important drawback is the activation of pathological phagocytes, which might result from continued tissue damage and lead to harmful diseases. The longer the inflammation persists, the greater the chance for the establishment of human diseases. The aim of this review was to focus on advances in the understanding of chronic inflammation and to summarize the impact and involvement of inflammatory agents in certain human diseases.

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Ankle brachial index most important to identify polyvascular disease in patients with non-ST elevation or ST-elevation myocardial infarction

Cited by 21 publications

References 25 publications

Role of Low Ankle–Brachial Index in Cardiovascular and Mortality Risk Compared with Major Risk Conditions

Role of Low Ankle–Brachial Index in Cardiovascular and Mortality Risk Compared with Major Risk Conditions

Sensitivity, Specificity, and Predictive Values: Foundations, Pliabilities, and Pitfalls in Research and Practice

The multifaceted link between inflammation and human diseases

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