Anisotropy characteristics of microstructures for bone substitutes and porous implants with application of additive manufacturing in orthopaedic

Kang, Jianfeng; Dong, Enchun; Li, Dichen; Dong, Shuangpeng; Zhang, Chen; Wang, Ling

doi:10.1016/j.matdes.2020.108608

Cited by 59 publications

(29 citation statements)

References 50 publications

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“…In other words, the increase of anisotropy value means, increased cell proliferation and pronounced tissue repair at the site of the lesion. According to recent studies by Kang et al , 44 who created an implantable device by 3D printing of biomaterials as well as Ti6Al4V titanium, that presented an anisotropic property similar to native bone. Thus, in the present study the presence of stem cells in the PLDLA-TMC/MSCs group improved the ossification process after 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

Poly(L-co-D,L lactic acid-co-Trimethylene Carbonate) 3D printed scaffold cultivated with mesenchymal stem cells directed to bone reconstruction: In vitro and in vivo studies

et al. 2022

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A recent and quite promising technique for bone tissue engineering is the 3D printing, peculiarly regarding the production of high-quality scaffolds. The 3D printed scaffold strictly provides suitable characteristics for living cells, in order to induce treatment, reconstruction and substitution of injured tissue. The purpose of this work was to evaluate the behavior of the 3D scaffold based on Poly(L-co-D,L lactic acid-co-Trimethylene Carbonate) (PLDLA-TMC), which was designed in Solidworks™ software, projected in 3D Slicer™, 3D printed in filament extrusion, cultured with mesenchymal stem cells (MSCs) and tested in vitro and in vivo models. For in vitro study, the MSCs were seeded in a PLDLA-TMC 3D scaffold with 600 μm pore size and submitted to proliferation and osteogenic differentiation. The in vivo assays implanted the PLDLA-TMC scaffolds with or without MSCs in the calvaria of Wistar rats submitted to 8 mm cranial bone defect, in periods of 8–12 weeks. The results showed that PLDLA-TMC 3D scaffolds favored adherence and cell growth, and suggests an osteoinductive activity, which means that the material itself augmented cellular differentiation. The implanted PLDLA-TMC containing MSCs, showed better results after 12 weeks prior grafting, due the absence of inflammatory processes, enlarged regeneration of bone tissue and facilitated angiogenesis. Notwithstanding, the 3D PLDLA-TMC itself implanted enriched tissue repair; the addition of cells known to upregulate tissue healing reinforce the perspectives for the PLDLA-TMC applications in the field of bone tissue engineering in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Poly(L-co-D,L lactic acid-co-Trimethylene Carbonate) 3D printed scaffold cultivated with mesenchymal stem cells directed to bone reconstruction: In vitro and in vivo studies

et al. 2022

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“…The results show significantly higher straightness value and thusly a more anisotropic structure at 8 W in the Chi/Gel group. The more anisotropic the matrix structure is the better are the biomechanical properties [ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae

Stoetzel

Malhan

Wild

et al. 2021

IJMS

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Osseointegration is a prerequisite for the long-term success of implants. Titanium implants are preferred for their biocompatibility and mechanical properties. Nonetheless, the need for early and immediate loading requires enhancing these properties by adding bioactive coatings. In this preclinical study, extracellular matrix properties and cellular balance at the implant/bone interface was examined. Polyelectrolyte multilayers of chitosan and gelatin or with chitosan and Hyaluronic acid fabricated on titanium alloy using a layer-by-layer self-assembly process were compared with native titanium alloy. The study aimed to histologically evaluate bone parameters that correlate to the biomechanical anchorage enhancement resulted from bioactive coatings of titanium implants in a rat animal model. Superior collagen fiber arrangements and an increased number of active osteocytes reflected a significant improvement of bone matrix quality at the bone interface of the chitosan/gelatin-coated titan implants over chitosan/hyaluronic acid-coated and native implants. Furthermore, the numbers and localization of osteoblasts and osteoclasts in the reparative and remodeling phases suggested a better cellular balance in the chitosan/Gel-coated group over the other two groups. Investigating the micro-mechanical properties of bone tissue at the interface can elucidate detailed discrepancies between different promising bioactive coatings of titanium alloys to maximize their benefit in future medical applications.

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“…Magnesium and its alloys are becoming research frontier in the field of biodegradable materials due to their adequate strength, lightweight, and natural biodegradability. For orthopedic implant application, Mg alloys possess similar mechanical characteristics with identical young's modulus (20–45 GPa) comparable to cortical bone (20–27 GPa) [ 1 ]. Additionally, Mg alloys mimic the mechanical anisotropic characteristic of cortical bone, which endows superior load-bearing capacity [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

Singh

Batra

Kumar

et al. 2023

Bioactive Materials

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Anisotropy characteristics of microstructures for bone substitutes and porous implants with application of additive manufacturing in orthopaedic

Cited by 59 publications

References 50 publications

Poly(L-co-D,L lactic acid-co-Trimethylene Carbonate) 3D printed scaffold cultivated with mesenchymal stem cells directed to bone reconstruction: In vitro and in vivo studies

Poly(L-co-D,L lactic acid-co-Trimethylene Carbonate) 3D printed scaffold cultivated with mesenchymal stem cells directed to bone reconstruction: In vitro and in vivo studies

Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae

Progress in bioactive surface coatings on biodegradable Mg alloys: A critical review towards clinical translation

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