Anisotropic elastic properties of human femoral cortical bone and relationships with composition and microstructure in elderly

Cai, Xiran; Follet, Hélène; Peralta, Laura; Gardegaront, Marc; Farlay, Delphine; Gauthier, Rémy; Yu, Boliang; Gineyts, Évelyne; Olivier, Cécile; Langer, Max; Gourrier, Aurélien; Mitton, David; Peyrin, Françoise; Grimal, Quentin; Laugier, Pascal

doi:10.1016/j.actbio.2019.03.043

Cited by 34 publications

(37 citation statements)

References 72 publications

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“…For a better understanding of the biomechanical properties of healthy and diseased bones, several studies have been done to establish their relationships with the composition at a local scale (Bala et al, 2011(Bala et al, , 2010Cai et al, 2019;Farlay et al, 2010;Lefèvre et al, 2019).…”

Section: I-introductionmentioning

confidence: 99%

Intrinsic properties of osteomalacia bone evaluated by nanoindentation and FTIRM analysis

Hadjab

Farlay

Crozier

et al. 2021

Journal of Biomechanics

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Osteomalacia is a pathological bone condition consisting in a deficient primary mineralization of the matrix, leading to an accumulation of osteoid tissue and reduced bone mechanical strength. The amounts, properties and organization of bone constituents at tissue level, are known to influence its mechanical properties. It is then important to investigate the relationship between mechanical behavior and tissue composition at this scale in order to provide a better understanding of bone fragility mechanisms associates with this pathology. Our purpose was to analyze the links between ultra-structural properties and the mechanical behavior of this pathological bone tissue (osteomalacia) at tissue level (mineral and osteoid separately, or global). Four bone biopsies were taken from patients with osteomalacia, and subsequently embedded, sectioned, and polished. Then nanoindentation tests were performed to determine local elastic modulus E, contact hardness Hc and true hardness H for both mineralized and organic bone phases and for the global bone. The creep of the bone was also studied using a special indentation procedure in order to assess viscoelasto-plastic (creep) bone behavior. This allowed a detailed study of the rheological models adapted to the bone and to calculate the parameters associated to a Burgers model. Ultrastructural parameters were measured by Fourier Transform InfraRed Microspectroscopy (FTIRM) on the same position as the indents. The use of rheological models confirmed a significant contribution from the organic phase on the viscous character of bone tissue. The elastic E and the elasto-plastic H c deformation were correlated to both collagen maturity and Mineral/Matrix. The pure plastic deformation H was only correlated to the mineral phase. Our data show that mineral phase greatly affects mechanical variables (moduli and viscosities) and that organic phase (as illustrated in osteoid tissue) may play an important role in the creep behavior of bone. In conclusion, this study brings mechanical and physicochemical values for osteoid and mineral phases.

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Section: I-introductionmentioning

confidence: 99%

Intrinsic properties of osteomalacia bone evaluated by nanoindentation and FTIRM analysis

Hadjab

Farlay

Crozier

et al. 2021

Journal of Biomechanics

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“…The results of the present study complete a detailed analysis of some idealizations relevant for cortical bone mesoscale elasticity modeling conducted during the last decade. The accuracy of more or less refined models has been evaluated by comparing model predictions to experimental values of anisotropic elastic coefficients obtained from samples of human donors (Granke et al 2011;Baumann et al 2012;Cai et al 2019b). The samples were typically imaged with high-resolution µCT (as for the present work) to obtain a representation of the microstructure and the matrix mineral content.…”

Section: Resultsmentioning

confidence: 99%

“…Porosity (volume fraction of pores) alone is known to explain the largest part of elasticity variations (Granke et al 2011;Cai et al 2019b). Indeed, a popular simple model for cortical bone is a homogeneous transversely isotropic matrix with fixed properties pervaded by elongated pores with a single orientation (e.g., (Hellmich and Ulm 2004;Parnell et al 2012;Baumann et al 2012;Gagliardi et al 2017)).…”

Section: Resultsmentioning

confidence: 99%

“…Indeed, a popular simple model for cortical bone is a homogeneous transversely isotropic matrix with fixed properties pervaded by elongated pores with a single orientation (e.g., (Hellmich and Ulm 2004;Parnell et al 2012;Baumann et al 2012;Gagliardi et al 2017)). This simple model, which disregards the details of the pore structure and the interindividual variations of matrix elasticity, accounts well for the variations of elastic properties with porosity (Hellmich and Ulm 2004;Granke et al 2015;Cai et al 2019b), or with the average orientation of mineral crystals (Baumann et al 2012), with errors compared to experimental data typically below 10% (average error for a collection of samples). Nevertheless this model has several potential biases and its accuracy for predicting the elasticity of a given specimen may not be as good as 10%.…”

Section: Resultsmentioning

confidence: 99%

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Maximum effect of the heterogeneity of tissue mineralization on the effective cortical bone elastic properties

Brémaud

Cai

Brenner

et al. 2021

Biomech Model Mechanobiol

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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“…Equation (4) was obtained by fitting to experimental data (compressional wave speed and mass density for human cortical bone samples). This data was obtained as described in [21]. Based on the Resonant Ultrasound Spectroscopy (RUS) method, anisotropic velocities are measured for cuboid specimens.…”

Section: Model Of Dolphin's Skullmentioning

confidence: 99%

Contribution of bone-reverberated waves to sound localization of dolphins: A numerical model

et al. 2020

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We implement a new algorithm to model acoustic wave propagation through and around a dolphin skull, using the k-Wave software package [1]. The equation of motion is integrated numerically in a complex three-dimensional structure via a pseudospectral scheme which, importantly, accounts for lateral heterogeneities in the mechanical properties of bone. Modeling wave propagation in the skull of dolphins contributes to our understanding of how their sound localization and echolocation mechanisms work. Dolphins are known to be highly effective at localizing sound sources; in particular, they have been shown to be equally sensitive to changes in the elevation and azimuth of the sound source, while other studied species, e.g. humans, are much more sensitive to the latter than to the former. A laboratory experiment conducted by our team on a dry skull [2] has shown that sound reverberated in bones could possibly play an important role in enhancing localization accuracy, and it has been speculated that the dolphin sound localization system could somehow rely on the analysis of this information. We employ our new numerical model to simulate the response of the same skull used by [2] to sound sources at a wide and dense set of locations on the vertical plane. This work is the first step towards the implementation of a new tool for modeling source (echo)location in dolphins; in future work, this will allow us to effectively explore a wide variety of emitted signals and anatomical features.

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Anisotropic elastic properties of human femoral cortical bone and relationships with composition and microstructure in elderly

Cited by 34 publications

References 72 publications

Intrinsic properties of osteomalacia bone evaluated by nanoindentation and FTIRM analysis

Intrinsic properties of osteomalacia bone evaluated by nanoindentation and FTIRM analysis

Maximum effect of the heterogeneity of tissue mineralization on the effective cortical bone elastic properties

Contribution of bone-reverberated waves to sound localization of dolphins: A numerical model

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