Anisakis simplex as a risk factor for relapsing acute urticaria: a case-control study

Falcão, Helena; Lunet, Nuno; Neves, Esmeralda; Iglesias, I.; Barros, Henrique

doi:10.1136/jech.2007.061572

Cited by 28 publications

(24 citation statements)

References 12 publications

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“…Regarding the Anisakis nematode, its role in recurrent acute urticaria is controversial (13). However, a paediatric case-control study involving 200 patients has found a significantly higher risk for relapsing acute urticaria in sensitized children (16). Fungi have not been stated as a cause of acute urticaria (13).…”

Section: Infectionsmentioning

confidence: 98%

Management of Childhood Urticaria: Current Knowledge and Practical Recommendations

Pité¹,

Wedi²,

Borrego³

et al. 2013

Acta Derm Venerol

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Urticaria, defined by the presence of wheals and/or angio-edema, is a common condition in children, prompting parents to consult physicians. For its successful management, paediatric-specific features must be taken into account, regarding the identification of eliciting triggers and pharmacological therapy. This review systematically discusses the current best-available evidence on spontaneous acute and chronic urticaria as well as physical and other urticaria types in children. Potential underlying causes, namely infections, food and drug hypersensitivity, autoreactivity and autoimmune or other conditions, and eliciting stimuli are considered, with practical recommendations for specific diagnostic approaches. Second-generation antihistamines are the mainstay of pharmacological treatment aimed at relief of symptoms, which require dose adjustment for pae-diatric use. Other therapeutic interventions are also discussed. In addition, unmet needs are highlighted, aiming to promote research into the paediatric population, ultimately aiming at the effective management of childhood urticaria.

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Section: Infectionsmentioning

confidence: 98%

Management of Childhood Urticaria: Current Knowledge and Practical Recommendations

Pité¹,

Wedi²,

Borrego³

et al. 2013

Acta Derm Venerol

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“…In southern countries acute urticaria might be caused by Anisakis simplex, a seafish nematode, after eating uncooked fish[22,23] However, the role of Anisakis in recurrent acute urticaria is discussed controversially [24-26]. Double blind placebo-controlled oral challenges with 100 lyophilized Anisakis simplex larvae, or its equivalent in antigen, did not induce clinical symptoms in individuals with a clinical history and laboratory findings of hypersensitivity to Anisakis simplex [27].…”

Section: Introductionmentioning

confidence: 99%

Urticaria and infections

Wedi

Raap

Wieczorek

et al. 2009

All Asth Clin Immun

169

139

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Urticaria is a group of diseases that share a distinct skin reaction pattern. Triggering of urticaria by infections has been discussed for many years but the exact role and pathogenesis of mast cell activation by infectious processes is unclear. In spontaneous acute urticaria there is no doubt for a causal relationship to infections and all chronic urticaria must have started as acute. Whereas in physical or distinct urticaria subtypes the evidence for infections is sparse, remission of annoying spontaneous chronic urticaria has been reported after successful treatment of persistent infections. Current summarizing available studies that evaluated the course of the chronic urticaria after proven Helicobacter eradication demonstrate a statistically significant benefit compared to untreated patients or Helicobacter-negative controls without urticaria (p < 0.001). Since infections can be easily treated some diagnostic procedures should be included in the routine work-up, especially the search for Helicobacter pylori. This review will update the reader regarding the role of infections in different urticaria subtypes.

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“…Recent shifts in gastronomic habits, especially the consumption of raw fish, have contributed to an increased awareness of fish parasites as a health risk. Anisakid larvae, especially Anisakis spp., can infect humans and cause anisakiosis, a condition that includes a number of mild to severe gastrointestinal problems, as well as acute allergic reactions (Audicana et al 2002;Falcão et al 2008;Hochberg and Hamer 2010). Recently, A. simplex extracts have been included in the standard sets of allergens for the evaluation of food allergies (Audicana and Kennedy 2008).…”

Section: Introductionmentioning

confidence: 99%

Infection levels and diversity of anisakid nematodes in blackspot seabream, Pagellus bogaraveo, from Portuguese waters

et al. 2011

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The blackspot seabream, Pagellus bogaraveo, is a sparid fish of great economic importance in the northeast Atlantic. The main aim of this work was to assess the infection levels and diversity of anisakid nematodes parasitizing P. bogaraveo from Portuguese waters. The anisakid larvae were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and ten different patterns were observed, four of which were not previously reported in the literature. Moreover, several species were detected for the first time in this host: Anisakis simplex × Anisakis pegreffii hybrids, Anisakis ziphidarum, Anisakis typica, Anisakis physeteris, as well as three undescribed anisakids Anisakis sp. PB-2009, Anisakis sp. PB-2010, and Contracaecum sp. PB-2010. The ITS1-5.8S-ITS2 region was sequenced and analyzed phylogenetically, revealing that our anisakids were distributed by the two distinct clades reported previously, corresponding to the two recognized larval morphotypes. Moreover, a group of organisms, including our specimens from Madeira and the previously reported Anisakis sp. HC-2005, cluster together and seem to belong to clade I. A certain degree of intraspecific diversity was also detected. Samples from mainland waters had the highest infection levels and were dominated by A. pegreffii. Madeira had the highest diversity overall, dominated by Anisakis sp. PB-2010. Fish from the Azores had the lowest infection levels, and the species with the highest relative abundance was A. physeteris. The anisakid nematode communities were relatively similar in mainland waters but very distinct in both the Azores and Madeira islands, suggesting the existence of at least three different stocks of P. bogaraveo in the northeast Atlantic.

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Anisakis simplex as a risk factor for relapsing acute urticaria: a case-control study

Abstract: Sensitisation to A simplex increases the risk of relapsing acute urticaria in subjects not sensitised to Ascaris or fish, and this is independent of aeroallergen sensitisation.

Cited by 28 publications

References 12 publications

Management of Childhood Urticaria: Current Knowledge and Practical Recommendations

Management of Childhood Urticaria: Current Knowledge and Practical Recommendations

Urticaria and infections

Infection levels and diversity of anisakid nematodes in blackspot seabream, Pagellus bogaraveo, from Portuguese waters

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