Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes

Xian, Mu; Wawrzyniak, Paulina; Rückert, Beate; Duan, Su; Meng, Yifan; Sokołowska, Milena; Głobińska, Anna; Zhang, Luo; Akdiş, Mübeccel

doi:10.1016/j.jaci.2016.07.003

Cited by 76 publications

(79 citation statements)

References 11 publications

(19 reference statements)

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“…The deteriorating effect of detergents is not limited to the SC. A recent study showed that anionic surfactants affect the barrier integrity through disruption of tight junctions . The changes on molecular level observed after exposures to SLS are consistent with reduction in the skin barrier function commonly assessed as transepidermal water loss (TEWL) and decreased hydration …”

Section: The Effects Of Skin Irritants and Allergens On The Skin Barriermentioning

confidence: 64%

The role of skin barrier in occupational contact dermatitis

Jakaša

Thyssen

Kežić

2018

Experimental Dermatology

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Skin diseases represent one of the most common work-related diseases and may have a detrimental effect on social, personal and occupational aspects of life. Contact dermatitis (CD), which comprises predominately irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), accounts for vast majority of occupational skin diseases, especially in occupations associated with frequent skin contact with irritants and contact allergens. Although ICD and ACD have similar clinical manifestation, their pathophysiology and the role of the skin barrier are different. In ICD, perturbation of the skin barrier is the primary event which sets into motion diverse metabolic processes and triggers activation of innate immunity without the involvement of adaptive immune system. In ACD, a type IV hypersensitivity reaction induced by contact allergens, the skin barrier impairment may evoke innate signalling pathways during the sensitization phase required for the activation of T-cell adaptive response. Thus, skin barrier impairment may increase the risk of ICD or ACD not only because of enhanced permeability and ingress of irritants and allergens but also by the generation of innate immune signal needed for the induction of allergic response. Hence, an efficient way to prevent CD is to avoid skin barrier damage in the workplace. This review focuses on the skin barrier, how it is affected by skin irritants and how its impairment contributes to the development of ICD and ACD.

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Section: The Effects Of Skin Irritants and Allergens On The Skin Barriermentioning

confidence: 64%

The role of skin barrier in occupational contact dermatitis

Jakaša

Thyssen

Kežić

2018

Experimental Dermatology

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“…157 Increased TEWL may reflect the spectrum of genetic and environmental factors leading to barrier impairment, such as water hardness, 158,159 frequency of washing, and commercial detergents (known to decrease tight junction barrier integrity in human keratinocytes). 127,128 These findings are being assessed in randomized controlled trials (RCTs) to prevent AD such as the SOFTER (Softened Water for Eczema Prevention) trial. 160 If the skin barrier is impaired, more water evaporates from the skin enabling allergens, irritants, and bacteria to penetrate the skin.…”

Section: Phenot Ypi C Me a Sure Of S K In Barrier Dys Fun C Tionmentioning

confidence: 99%

Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?

Brough

Nadeau

Sindher

et al. 2020

Allergy

180

168

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There is increasing evidence regarding the importance of allergic sensitization through the skin. In this review, we provide an overview of the atopic march and immune mechanism underlying the sensitization and effector phase of food allergy. We present experimental models and human data that support the concept of epicutaneous sensitization and how this forms one half of the dual‐allergen exposure hypothesis. We discuss specific important elements in the skin (FLG and other skin barrier gene mutations, Langerhans cells, type 2 innate lymphoid cells, IL‐33, TSLP) that have important roles in the development of allergic responses as well as the body of evidence on environmental allergen exposure and how this can sensitize an individual. Given the link between skin barrier impairment, atopic dermatitis, food allergy, allergic asthma, and allergic rhinitis, it is logical that restoring the skin barrier and prevention or treating atopic dermatitis would have beneficial effects on prevention of related allergic diseases, particularly food allergy. We present the experimental and human studies that have evaluated this approach and discuss various factors which may influence the success of these approaches, such as the type of emollient chosen for the intervention, the role of managing skin inflammation, and differences between primary and secondary prevention of atopic dermatitis to achieve the desired outcome.

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“…Barrier epithelial cells function as an origin of allergic response to external signals from the mucous membranes of the respiratory tract, intestinal tract, or skin. Tight junction barriers are extremely sensitive to detergents . LPS also increases tight junction permeability in a TLR4‐dependent manner .…”

Section: Toll‐like Receptorsmentioning

confidence: 99%

Innate immunity in allergy

Maeda

Caldez

Akira

2019

Allergy

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Innate immune system quickly responds to invasion of microbes and foreign substances through the extracellular and intracellular sensing receptors, which recognize distinctive molecular and structural patterns. The recognition of innate immune receptors leads to the induction of inflammatory and adaptive immune responses by activating downstream signaling pathways. Allergy is an immune‐related disease and results from a hypersensitive immune response to harmless substances in the environment. However, less is known about the activation of innate immunity during exposure to allergens. New insights into the innate immune system by sensors and their signaling cascades provide us with more important clues and a framework for understanding allergy disorders. In this review, we will focus on recent advances in the innate immune sensing system.

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Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes

Cited by 76 publications

References 11 publications

The role of skin barrier in occupational contact dermatitis

The role of skin barrier in occupational contact dermatitis

Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?

Innate immunity in allergy

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