Animal studies in orthodontics—Are they useful for clinicians?

Hans, Mark G.; Tsolakis, Konstantinos I.; Cain, David A.; Elbarnashawy, Sherif; Valiathan, Manish

doi:10.1053/j.sodo.2017.07.006

Cited by 2 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The predominant animal in the studies of our review was the rat [ 12 , 16 , 18 , 42 , 59 , 60 ], although Desai et al [ 44 ] experimented on rabbits and earlier studies have selected the monkey. The age of the animals is of importance because mandibular growth is related to general growth, and varies in relation to chronological age [ 6 , 70 , 71 ]. The age of the animals was clearly reported, but varied from 4 weeks [ 59 ], 5 weeks [ 12 ], 6 weeks in the papers by Hua et al [ 60 ] and Wang et al [ 42 ] up to 8 weeks [ 16 , 18 ], and even 9 months in rabbits [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dental professionals treating patients would like to know whether a given treatment modality involving posterior mandibular dislocation has a stable effect on the net growth and consequently the facial dimensions, which affect the appearance [ 6 ]. Nevertheless, the studies being reviewed here are heterogeneous regarding their outcomes and they predominantly report on histology and biochemistry despite the use of lateral radiography.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment in cases of extreme mandibular growth has been a challenge [ 6 , 7 ] and research has focused on the anatomy, histology and function of the TMJ [ 8 , 9 , 10 ] seeking the trigger of growth [ 11 ]. In experiments and in clinical practice, the mandible has been pushed backwards, mainly during the period of growth, for protrusion to alleviate [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Posterior Mandibular Displacement—A Systematic Review Based on Animal Studies

Lyros

Makrygiannakis

Lykogeorgos³

et al. 2021

Animals

View full text Add to dashboard Cite

Treating extreme mandibular growth is challenging. The mandible is pushed backwards to address itsprotrusion. Nevertheless, conclusions after such displacement in animals have been contradictory. The aim of the present review is to present measurable alterations of the mandible and the condyle following retractionin healthy rats or rabbits. PubMed, Scopus and Web of Science were accessed for relevant studies up to October 2020. Eligibility was determined by the PICOS process, while the risk of bias was estimated with SYRCLE’s risk of bias tool. Retraction resulted in a more distal molar occlusion and the condyle rested more posteriorly. Mandibular anteroposterior bilateral growth restriction was achieved, the condylar process measured smaller and its angulation increased. The condylar neck thickened, its posterior surface flattened, the coronoid process was measured longer, and enlarged retromolar density was registered. Differences in the ramus height and the intercondylar distance were insignificant. Changes persisted for the period of study and subsequently the mandible resumed its inherited growth pattern. The timing of mandibular shaping and TMJ outcomes might depend on the properties of the applied force. Stability is of concern and well-structured, long-term studies are expected to resolve the issue and further clarify the results of posterior mandibular displacement.

show abstract