Animal Models of Traumatic Brain Injury

Clausen, Fredrik

doi:10.1007/978-1-4939-3730-1_1

Cited by 1 publication

(4 citation statements)

References 15 publications

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“…Following the same protocol previously described 11,12 . The implants were harvested with its surrounding capsule (granulation tissue), then were placed in a solution of Saline 0.9% at room temperature.…”

Section: Methodsmentioning

confidence: 99%

“…Eye lubricant was applied routinely to prevent corneal lesions. A local single dose of lidocaine 1 mg/kg in the region of incision 11,12 …”

Section: Methodsmentioning

confidence: 99%

“…A local single dose of lidocaine 1 mg/kg in the region of incision. 11,12 The subjects were monitored in search of pain, and continuous anesthetic plane was inspected. Antiseptics and aseptic measures were taken according to International Council for Laboratory Animal Science and Institutional protocols.…”

Section: First Stage Proceduresmentioning

confidence: 99%

“…Following the same protocol previously described. 11,12 The implants were harvested with its surrounding capsule (granulation tissue), then were placed in a solution of Saline 0.9% at room temperature. The wound was closed again, and then in the previously prepared cranial area a craniectomy was performed.…”

Section: Second Stage Proceduresmentioning

confidence: 99%

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Initial Histological Evaluation of a Novel Dura Mater Graft Based on Capsule Granulation Harvested From Subcutaneous Tissue: Experimental Model

Rendón-Medina¹,

Galeana-Pavón

Vázquez-Medina³

et al. 2021

Journal of Craniofacial Surgery

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Introduction: Autografts are useful but unfortunately are limited in big dural defects, in such cases, synthetic implants have been recommended. Extensive evidence in the literature suggests that sometimes synthetic implants had high rates of complications like infections. This paper aims to present a novel dura matter graft based on capsule granulation tissue harvested from subcutaneous space as a dura substitute and its histological findings. Materials and Methods: Wistar rats between 240 and 430 grams of both genders were included. First stage procedure introducing silicon spheres in the subcutaneous tissue. Second stage procedure 4 weeks later harvested de capsule granulation tissue that contain them. Then a craniectomy was performed to create a dura mater defect. This defect was reconstructed with the granulation tissue was placed onlay the defect. After another 4 weeks the subjects were euthanized and sent to an external pathology unit for analysis with validated integration scales. Results: A total of 5 subjects were included (3 males and 2 females) with weight between 240 and 430 grams. Only 2 outcome out of 6 scales had significance difference between the samples: adhesions P ¼ 0.011 and integration P ¼ 0.006. Conclusions: The histological findings shown that capsule granulation graft is a compatible, autologous compatible substitute for dura mater. It has a great potential of full integration and an acceptable grade of adhesions.

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Section: Methodsmentioning

confidence: 99%

“…Eye lubricant was applied routinely to prevent corneal lesions. A local single dose of lidocaine 1 mg/kg in the region of incision 11,12 …”

Section: Methodsmentioning

confidence: 99%

Section: First Stage Proceduresmentioning

confidence: 99%

Section: Second Stage Proceduresmentioning

confidence: 99%

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