Animal models of rheumatoid arthritis and their relevance to human disease

Kannan, K.; Ortmann, Robert A.; Kimpel, Donald L.

doi:10.1016/j.pathophys.2005.07.011

Cited by 197 publications

(196 citation statements)

References 123 publications

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“…Production of TNF␣, IL-1␤, and IL-6 correlates with the degree of inflammation in arthritic rats (55) ( Table 3). No clear correlation exists between the severity of arthritis and antibody production to PG-PS, which is minimal (8). Two strains of rats with the same MHC differ in susceptibility, indicating that there is no association between disease development and specific MHC alleles.…”

Section: Evaluation Of Therapeutic Targets In Animal Models Of Arthritismentioning

confidence: 95%

“…This subsides in a few days, with diffuse infiltration of the synovium containing lymphocytes and monocytes remaining in the joint. After the initial intraarticular injection, the joints are sensitized, and inflammation in the joint can be reactivated by intravenously administered PG-PS 100P, lipopolysaccharide, or superantigen (8).…”

Section: Evaluation Of Therapeutic Targets In Animal Models Of Arthritismentioning

confidence: 99%

“…In addition to the induced-arthritis models, arthritis develops spontaneously in some genetically modified mice (8,61). These are mice that are either deficient in (knockout) or transgenic for a specific gene of interest.…”

Section: Transgenic Mouse Models Of Ramentioning

confidence: 99%

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Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Bevaart¹,

Vervoordeldonk²,

Tak³

2010

Arthritis & Rheumatism

229

193

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There are accumulating data describing the association between diabetes and cancer mortality from Westernised populations. There are no data describing the relationship between diabetes and cancer mortality in African or South Asian populations from developing countries. We explored the relationship of abnormal glucose tolerance and diabetes on cancer mortality risk in a large, multi‐ethnic cohort from the developing nation of Mauritius. Population‐based surveys were undertaken in 1987, 1992 and 1998. The 9559 participants comprised 66% of South Asian (Indian), 27% of African (Creole), and 7% of Chinese descent. Cox's proportional hazards model with time varying covariates was used to obtain hazard ratios (HRs) and 95% confidence intervals (95% CI) for risk of cancer mortality, after adjustment for confounding factors. In men, but not women, cancer mortality risk increased with rising 2h‐PG levels with HR for the top versus bottom quintile of 2.77 (95%CI: 1.28 to 5.98). South Asian men with known diabetes had a significantly greater risk of cancer mortality than those with normal glucose tolerance (NGT) HR: 2.74 (95%CI: 1.00‐7.56). Overall, impaired glucose tolerance was associated with an elevated risk of cancer mortality compared to NGT (HR: 1.47, 95% CI: 0.98–2.19), though this was not significant. We have shown that the association between abnormal glucose tolerance and cancer extends to those of African and South Asian descent. These results highlight the importance of understanding this relationship in a global context to direct future health policy given the rapid increase in type 2 diabetes, especially in developing nations.

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Section: Evaluation Of Therapeutic Targets In Animal Models Of Arthritismentioning

confidence: 95%

Section: Evaluation Of Therapeutic Targets In Animal Models Of Arthritismentioning

confidence: 99%

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Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Bevaart¹,

Vervoordeldonk²,

Tak³

2010

Arthritis & Rheumatism

229

193

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“…1 Numerous studies have indicated the participation of the MHC class II alleles and non-MHC genes, such as the solute carrier family 11a member 1 (SLC11A1) (formerly named NRAMP1 -natural resistance associated macrophage protein 1) related to macrophage activation. [2][3][4] Several studies have used different animal models for arthritis, generally induced by the injection of adjuvants, proteoglycan (PGIA), type II collagen (CIA) or pristane (PIA), 5 to investigate RA-controlling loci. Pristane-induced arthritis (PIA) has proven to be a valuable experimental model for RA.…”

Section: Introductionmentioning

confidence: 99%

Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice

et al. 2006

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Mice selected for the maximum acute inflammatory reaction (AIRmax) are highly susceptible to pristane-induced arthritis (PIA), whereas mice selected for the minimum response (AIRmin) are resistant. These lines show distinct patterns of leukocyte infiltration and R and S allele frequency disequilibrium of the solute carrier family 11a member 1 (Slc11a1) gene. In order to study the interactions of the Slc11a1 R and S alleles with the inflammation modulating Quantitative Trait Loci (QTL) during PIA development, homozygous AIRmax RR , AIRmax SS , AIRmin RR and AIRmin SS lines were produced by genotype-assisted breedings. These mice received two intraperitoneal injections of 0.5 ml pristane at 60-day intervals, and the subsequent development of arthritis was assessed for 210 days. Cytokine-secreting cell profiles were investigated using enzyme-linked immunospot. Arthritis incidence in AIRmax RR mice reached 29%, whereas PIA incidence in AIRmax SS mice was 70% by day 180. AIRmin RR mice were resistant, whereas 13.3% of AIRmin SS mice became arthritic. The presence of the defective S allele also increased arthritis severity, although acute inflammation was higher in mice bearing the R allele. A predominant Th0/Th2-type response in Slc11a1 SS mice was observed. These results indicate that Slc11a1 is a strong candidate for the QTL modulating acute inflammation and for PIA.

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“…To dissect disease pathways and genes modulating arthritis development, several animal models are used [1,2]. Most of the induced models of arthritis (both chronic and acute) use an adjuvant either at the time of administration of protein antigen or later for inducing/ enhancing disease development.…”

Section: Introductionmentioning

confidence: 99%

Adjuvant properties of a biocompatible thermo-responsive polymer of N -isopropylacrylamide in autoimmunity and arthritis

Shakya

Kumar

Nandakumar

2011

J. R. Soc. Interface.

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To evaluate the thermo-responsive poly(N-isopropylacrylamide) (PNiPAAm) polymer as an adjuvant, we synthesized PNiPAAm through free radical polymerization and characterized it both in vitro and in vivo. The polymer when mixed with collagen type II (CII) induced antigen-specific autoimmunity and arthritis. Mice immunized with PNiPAAm-CII developed significant levels of CII-specific IgG response comprising major IgG subclasses. Antigen-specific cellular recall response was also enhanced in these mice, while negligible level of IFN-g was detected in splenocyte cultures, in vitro. PNiPAAm-CII-immunized arthritic mouse paws showed massive infiltration of immune cells and extensive damage to cartilage and bone. As determined by immunostaining, most of the CII protein retained its native configuration after injecting it with PNiPAAm in naive mice. Physical adsorption of CII and the highmolecular-weight form of moderately hydrophobic PNiPAAm induced a significant anti-CII antibody response. Similar to CII, mice immunized with PNiPAAm and ovalbumin (PNiPAAm-Ova) induced significant anti-ovalbumin antibody response. Comparable levels of serum IFN-g, IL-1b and IL-17 were observed in ovalbumin-immunized mice with complete Freund, incomplete Freund (CFA and IFA) or PNiPAAm adjuvants. However, serum IL-4 levels were significantly higher in PNiPAAm-Ova and CFA-Ova groups compared with the IFA-Ova group. Thus, we show for the first time, biocompatible and biodegradable thermo-responsive PNiPAAm can be used as an adjuvant in several immunological applications as well as in better understanding of the autoimmune responses against self-proteins.

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Animal models of rheumatoid arthritis and their relevance to human disease

Cited by 197 publications

References 123 publications

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Evaluation of therapeutic targets in animal models of arthritis: How does it relate to rheumatoid arthritis?

Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice

Adjuvant properties of a biocompatible thermo-responsive polymer of N -isopropylacrylamide in autoimmunity and arthritis

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