Animal models of osteoarthritis for the understanding of the bone contribution

Cohen‐Solal, Martine; Funck‐Brentano, Thomas; Haÿ, Eric

doi:10.1038/bonekey.2013.156

Cited by 20 publications

(19 citation statements)

References 36 publications

(37 reference statements)

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“…Numerous animal models of OA have been developed to mimic pathologic human cartilage 22 . Among these different models, transection of the ACLT+MM has been one of the most widely used to induce OA, The joint instability caused by ACLT damage further leads to biological mechanics changes resemble the morphologic and biochemical changes seen in human OA 23 .…”

Section: Effects Of Cos On the Ratio Of Opg/rankl And Rankl/rank In Rmentioning

confidence: 99%

The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

Zhang

Jiang

et al. 2017

Acta Cir. Bras.

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Purpose: To investigate the effect of chitosan oligosaccharides (COS) against osteoarthritis (OA) and preliminarily discuss the osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL) and RANK expression in a rat OA model. Methods: Thirty-six 6-week-old Male SD rats were randomly divided into three groups: shamoperated group(CON), OA-induction group(OA), COS intervention group(n=12/group). At 4 weeks after the operation, COS (50 ul) intervention weekily for consecutive 5 weeks. The OA and CON groups received an injection of 50 ul physiological saline. At death, 11 weeks following surgery, cartilage was harvested and total RNA and protein were extracted. Both the morphological changes of the cartilage were observed and harvested the total RNA and protein.Meanwhile, the expression of OPG, RANKL and RANK in cartilage were determined. Results: The expression of OPG and RANKL were both enhanced in the cartilage of the OA model. Compared with the OA group, COS treatment improved the cartilage damage (both extent and grade). Furthermore, the COS group showed highly OPG and lower RANKL. Simultaneously, COS treatment upregulated the ratio of OPG/RANKL and downregulated the RANKL/RANK. Conclusion: Chitosan oligosaccharides may be used as a unique biological agent to prevent and treat osteoarthritis, and this effect is associated with modulation of the expression of osteoprotegerin and receptor activator of NF-κB ligand.

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Section: Effects Of Cos On the Ratio Of Opg/rankl And Rankl/rank In Rmentioning

confidence: 99%

The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

Zhang

Jiang

et al. 2017

Acta Cir. Bras.

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“…Very little is known about the early changes of bone microstructure in human osteoarthritis studies, and the majority of our current knowledge is brought by animal models [42]. Most of these models are consistent and report an early increase in bone resorption followed in later stages with an increase in formation [43].…”

Section: Subchondral Bone Changes At the Tissue Levelmentioning

confidence: 96%

Subchondral bone and osteoarthritis

Funck‐Brentano

Cohen‐Solal

2015

Current Opinion in Rheumatology

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103

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The involvement of bone in osteoarthritis has long been thought to be secondary to cartilage damage as an adaptation of the joint. Recent clinical studies with MRI have demonstrated that bone changes could be observed in early stages of the disease, even preceding cartilage lesions. Moreover, there is clear evidence of an association between subchondral bone mineral density and osteoarthritis. The level of bone remodeling plays a critical role under mechanical loading conditions as demonstrated by consistent experimental studies. Yet new clinical biomarkers are being developed to assess the bone phenotype of osteoarthritic patients. This stratification strategy is likely to better identify groups of patients who would benefit from bone-acting drugs to decrease disease progression and improve pain and disability.

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“…In addition, these findings could also explain regional and subregional variation in bone microstructure of the OA BML group. The conclusion was that BML areas represent "hot spots" in the tibial plateau where changes in the bone microstructure might be the result of an acute localised tissue response as well as a pathophysiological interaction between the bone and cartilage 1,24 .…”

Section: Structural Differences In the Subchondral Bone Plate And Tramentioning

confidence: 99%

Bone marrow lesions in knee osteoarthritis: regional differences in tibial subchondral bone microstructure and their association with cartilage degeneration

Muratovic

Findlay

Cicuttini

et al. 2019

Osteoarthritis and Cartilage

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The aim of this study was to investigate how bone microstructure within bone marrow lesions (BMLs) relates to the bone and cartilage across the whole human tibial plateau. Design: Thirty-two tibial plateaus from patients with osteoarthritis (OA) at total knee arthroplasty and eleven age-matched non-OA controls, were scanned ex vivo by MRI to identify BMLs and by micro CT to quantitate the subchondral (plate and trabecular) bone microstructure. For cartilage evaluation, specimens were processed histologically. Results: BMLs were detected in 75% of the OA samples (OA-BML), located predominantly in the anteriormedial (AM) region. In contrast to non-OA control and OA-no BML, in OA-BML differences in microstructure were significantly more evident between subregions. In OA-BML, the AM region contained the most prominent structural alterations. Between-group comparisons showed that the AM region of the OA-BML group had significantly higher histological degeneration (OARSI grade) (P < .0001, P < .05), thicker subchondral plate (P < .05, P < .05), trabeculae that are more anisotropic (P < .0001, P < .05), well connected (P < .05, P ¼ n.s), and more plate-like (P < 0.05, P < 0.05), compared to controls and OA-no BML at this site. Compared to controls, OA-no BML had significantly higher OARSI grade (P < .0001), and lower trabecular number (P < .05). Conclusion: In established knee OA, both the extent of cartilage damage and microstructural degeneration of the subchondral bone were dependent on the presence of a BML. In OA-no BML, bone microstructural alterations are consistent with a bone attrition phase of the disease. Thus, the use of BMLs as MRI image-based biomarkers appear to inform on the degenerative state within the osteochondral unit.

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Animal models of osteoarthritis for the understanding of the bone contribution

Cited by 20 publications

References 36 publications

The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model

Subchondral bone and osteoarthritis

Bone marrow lesions in knee osteoarthritis: regional differences in tibial subchondral bone microstructure and their association with cartilage degeneration

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