Subchondral bone and osteoarthritis

Funck‐Brentano, Thomas; Cohen‐Solal, Martine

doi:10.1097/bor.0000000000000181

Cited by 103 publications

(91 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Yet, new clinical biomarkers have being developed to assess the bone phenotype of osteoarthritic patients. This stratification strategy is likely to better identify groups of patients who would benefit from bone-acting drugs to decrease disease progression and improve pain and disability[13]. …”

Section: Etiopathology Of Arthritismentioning

confidence: 99%

Role of fetuin A in the diagnosis and treatment of joint arthritis

Pappa

Perrea

Pneumaticos

et al. 2017

WJO

View full text Add to dashboard Cite

Osteoarthritis is a slowly progressive disease which includes the intervention of several cytokines, macrophage metalleinoproteinases reaction, leading to the degradation of the local cartilage but also having an impact on the serum acute phase proteins (APPs). Subsequently, biomarkers seem to be essential to estimate its progression and the need for any surgical intervention such as total arthroplasty, but also can be used as therapeutic agents. Recently, among APPs, fetuin A drew attention regarding its possible anti-inflammatory role in animal models but also as a therapeutic agent in the inflammatory joint disease in clinical trials. In contrast with other APPs such as C-reactive protein, fetuin A appears to be lower in the serum of patients with degenerative joint disease in comparison with the healthy ones, and also acts as an antagonist of the anti-proliferative potential of transforming growth factor-β (TGF-β) cytokines. Because of its lower serum levels in arthritis, an unregulated binding of TGF-β and bone morphogenetic proteins takes place leading to further arthritic lesions. The purpose of the present review is to assess the current evidence regarding the multipotent role of the alpha-2-HS-glycoprotein or as also known Fetuin-a in animal models but also as a biomarker of the degenerative joint arthritis in clinical trials.

show abstract

Section: Etiopathology Of Arthritismentioning

confidence: 99%

Role of fetuin A in the diagnosis and treatment of joint arthritis

Pappa

Perrea

Pneumaticos

et al. 2017

WJO

View full text Add to dashboard Cite

show abstract

“…Decreased local mineralization, increases in subchondral bone metabolism, and sclerosis occur in the progression of OA [Lories and Luyten, 2011;Suri and Walsh, 2012]. Biochemical and molecular crosstalk between subchondral bone and cartilage are of particular importance in pathogenesis of the disease [Hayami et al, 2004;Lories and Luyten, 2011;Yuan et al, 2014;Funck-Brentano and Cohen-Solal, 2015]. Biochemical and molecular crosstalk between subchondral bone and cartilage are of particular importance in pathogenesis of the disease [Hayami et al, 2004;Lories and Luyten, 2011;Yuan et al, 2014;Funck-Brentano and Cohen-Solal, 2015].…”

Section: Introductionmentioning

confidence: 99%

Pulsed electromagnetic field at different stages of knee osteoarthritis in rats induced by low‐dose monosodium iodoacetate: Effect on subchondral trabecular bone microarchitecture and cartilage degradation

Yang

Zhou

et al. 2016

Bioelectromagnetics

View full text Add to dashboard Cite

The aim of the study was to investigate the efficacy of pre-emptive, early, and delayed pulsed electromagnetic field (PEMF) treatment on cartilage and subchondral trabecular bone in knee osteoarthritis (OA) rats induced by low-dose monosodium iodoacetate (MIA). Seventy-five 12-week-old male Sprague-Dawley rats were assigned to five groups: OA (n = 30), pre-emptive PEMF (n = 10), early PEMF (n = 10), delayed PEMF (n = 10), and control (n = 15). Osteoarthritis was induced by injecting 0.2 mg MIA in rat's right knee joint. Control rats received a single sterile saline injection in the right knee. Male rats received pre-emptive (n = 10, day 0-end of week 4), early (n = 10, end of week 4-end of week 8), or delayed (n = 10, end of week 8-end of week 12) PEMF treatment (75 Hz, 1.6 mT). After 4, 8, and 12 weeks, rats were sacrificed at each time point and right knees were harvested. After sacrifice, micro-computed tomography, histology, and biomarker analyses were performed. We found pre-emptive PEMF treatment preserved subchondral trabecular bone microarchitecture and prevented subchondral bone loss in MIA-induced OA rat model. Early and delayed PEMF treatment maintained subchondral trabeculae. PEMF treatment increased bone and cartilage formation, and decreased bone and cartilage resorption. Pre-emptive and early PEMF treatment had moderate effects on cartilage degradation. Time point of treatment initiation is crucial for treating OA. PEMF might become a potential biophysical treatment modality for osteoarthritis. Bioelectromagnetics. 38:227-238, 2017. © 2016 Wiley Periodicals, Inc.

show abstract

“…Subchondral trabecular bone changes such as metabolism and sclerosis, as well as modification of trabecular architecture happen before symptoms occur[19,20]. The inability to quantify phenotypes of abnormal subchondral bone texture is a severe bottleneck in understanding early stages of OA.…”

Section: Discussionmentioning

confidence: 99%

Detection of bone loss via subchondral bone analysis

Vimort

Ruellas

Prothero

et al. 2018

Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging

View full text Add to dashboard Cite

To date, there is no single sign, symptom, or test that can clearly diagnose early stages of Temporomandibular Joint Osteoarthritis (TMJ OA). However, it has been observed that changes in the bone occur in early stages of this disease, involving structural changes both in the texture and morphometry of the bone marrow and the subchondral cortical plate. In this paper we present a tool to detect and highlight subtle variations in subchondral bone structure obtained from high resolution Cone Beam Computed Tomography (hr-CBCT) in order to help with detecting early TMJ OA. The proposed tool was developed in ITK and 3DSlicer and it has been disseminated as open-source software tools. We have validated both our texture analysis and morphometry analysis biomarkers for detection of TMJ OA comparing hr-CBCT to μCT. Our initial statistical results using the multidimensional features computed with our tool indicate that it is possible to classify areas of demonstrated loss of trabecular bone in both μCT and hr-CBCT. This paper describes the first steps to alleviate the current inability of radiological changes to diagnose TMJ OA before morphological changes are too advanced by quantifying subchondral bone biomarkers. This paper indicates that texture based and morphometry based biomarkers have the potential to identify OA patients at risk for further bone destruction.

show abstract

Subchondral bone and osteoarthritis

Cited by 103 publications

References 67 publications

Role of fetuin A in the diagnosis and treatment of joint arthritis

Role of fetuin A in the diagnosis and treatment of joint arthritis

Pulsed electromagnetic field at different stages of knee osteoarthritis in rats induced by low‐dose monosodium iodoacetate: Effect on subchondral trabecular bone microarchitecture and cartilage degradation

Detection of bone loss via subchondral bone analysis

Contact Info

Product

Resources

About