Animal Models of Colitis: Lessons Learned, and Their Relevance to the Clinic

Barnett, Matthew P. G.; Fraser, Alan G.

doi:10.5772/27431

Cited by 16 publications

(17 citation statements)

References 78 publications

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“…The available IBD animal models comprise chemically induced models, adoptive transfer models and genetically modified animals (115) .…”

Section: From Mouse To Men -Translation Into the Clinicmentioning

confidence: 99%

“…The establishment of more clearly defined clinical phenotypes and application of genetic tests in clinical medicine would enable more accurate matching of mouse models to patients, which will eventually lead to more appropriate therapy. In terms of monitoring the effectiveness of therapy and classification, the identification of appropriate diagnostic biomarkers would be of important benefit in this context (115) .…”

Section: From Mouse To Men -Translation Into the Clinicmentioning

confidence: 99%

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Nanomedicines for the treatment of inflammatory bowel diseases

Ali

Collnot

Windbergs³

et al. 2013

European Journal of Nanomedicine

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“…The available IBD animal models comprise chemically induced models, adoptive transfer models and genetically modified animals (115) .…”

Section: From Mouse To Men -Translation Into the Clinicmentioning

confidence: 99%

Section: From Mouse To Men -Translation Into the Clinicmentioning

confidence: 99%

Nanomedicines for the treatment of inflammatory bowel diseases

Ali

Collnot

Windbergs³

et al. 2013

European Journal of Nanomedicine

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“…3 The lesions in most IBD models are limited to the mucosa or submucosa area and the observed lesions resemble those found in colitis; as such, no existing models satisfactorily recapitulate the human disease. 4 The animal model used in this study, however, showed inflammatory cell infiltration in all colonic layers (including the muscular layer) and exhibited lesions similar to those found in Crohn's disease. 1 This paper does take a novel approach by studying changes in smooth muscle and motility in an immunodeficiency model.…”

mentioning

confidence: 98%

Does Decreased c-KIT Expression in Myenteric Interstitial Cells of Cajal Cause Decreased Spontaneous Contraction in Murine Proximal Colon?

Lee

2015

J Neurogastroenterol Motil

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In the current issue of the Journal of Neurogastroenterology and Motility, an article entitled "Alterations of colonic contractility in an IL-10 knockout mouse model of inflammatory bowel disease" demonstrated that interleukin-10 (IL-10) knockout mice exhibited altered colonic contractility and damaged interstitial cells of Cajal (ICC) networks. It also exhibited a decreased cholinergic response, caused by lowered expression of muscarinic receptors in the proximal colon and decreased neuronal nitric oxide synthase expression in both proximal and distal colon. For the past decades, more than 60 different animal models have been applied to study inflammatory bowel disease (IBD), which can be divided into chemically induced, cell-transfer, congenital mutant and genetically engineered models.2 Genetic techniques such as inducible knockout and knockin systems make it possible to characterize the mechanisms that are dysregulated in IBD.2 Up to date, most IBD studies have focused on mucosal inflammation and healing or related pathomechanisms. 3 The lesions in most IBD models are limited to the mucosa or submucosa area and the observed lesions resemble those found in colitis; as such, no existing models satisfactorily recapitulate the human disease. 4The animal model used in this study, however, showed inflammatory cell infiltration in all colonic layers (including the muscular layer) and exhibited lesions similar to those found in Crohn's disease. 1 This paper does take a novel approach by studying changes in smooth muscle and motility in an immunodeficiency model. The findings from this paper suggest that IL-10

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“…This should enable more successful strategies for the prevention and amelioration of this debilitating condition [54].…”

Section: Commentmentioning

confidence: 99%

“…The growing prevalence of this disease increases both economic and health care burdens [23]. Animal models of inflammatory bowel diseases have significant advantages -one can investigate not only factors concerned in pathogenesis, but also the secondary effects of ulceration, e.g., liver changes, effects on protein metabolism, electrolytic changes in the cellular and extracellular spaces, and other systemic complications [53,54].…”

Section: Commentmentioning

confidence: 99%

Etiological Role of Sulfate-Reducing Bacteria in the Development of Inflammatory Bowel Diseases and Ulcerative Colitis

Kushkevych¹

2014

AJIDM

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Inflammatory bowel disease and ulcerative colitis are complex multifactorial diseases of unknown etiology. The etiological role of the sulfate-reducing bacteria Desulfovibrio piger Vib-7 and Desulfomicrobium sp. Rod-9 in the development of these inflammatory diseases in rats was studied. Applying sulfate-reducing bacteria, ulcerative colitis in the animals was experimentally induced at the fist time. In total 45 animals in three groups were separated and used in this experiment. Animals in the first group received the standard diet containing a special certified feed for rats and were used as a control. The second group received the standard feed and a dose (1 ml per each day) of modified Kravtsov-Sorokin's liquid medium for the initiation of own potential animal intestinal microflora of sulfate-reducing bacteria. The third group of the animals received the standard feed and dose of a suspension with D. piger Vib-7 and Desulfomicrobium sp. Rod-9 (at a ratio of 1 to 1) in the medium. The changes in the colonic microbiota under these conditions were studied. The bacteria belonging to the normal colonic microbiota were associated with the etiology of inflammatory bowel disease and ulcerative colitis. The concentration of sulfide and acetate in feces from different sections of the large intestine of the rats was determined. The level of ulcerations in the second and third groups of sick animals under the specific conditions was demonstrated. The described experimental results could be particularly useful for the study of inflammatory bowel disease and ulcerative colitis and its therapeutic strategy. These data are also indispensable to apply into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis. Keywords

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Animal Models of Colitis: Lessons Learned, and Their Relevance to the Clinic

Cited by 16 publications

References 78 publications

Nanomedicines for the treatment of inflammatory bowel diseases

Nanomedicines for the treatment of inflammatory bowel diseases

Does Decreased c-KIT Expression in Myenteric Interstitial Cells of Cajal Cause Decreased Spontaneous Contraction in Murine Proximal Colon?

Etiological Role of Sulfate-Reducing Bacteria in the Development of Inflammatory Bowel Diseases and Ulcerative Colitis

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