Animal models of acute renal failure

Abstract

The animal models are pivotal for understanding the characteristics of acute renal failure (ARF) and development of effective therapy for its optimal management. Since the etiology for induction of renal failure is multifold, therefore, a large number of animal models have been developed to mimic the clinical conditions of renal failure. Glycerol-induced renal failure closely mimics the rhabdomyolysis; ischemia-reperfusion-induced ARF simulate the hemodynamic changes-induced changes in renal functioning; drug-induced such as gentamicin, cisplatin, NSAID, ifosfamide-induced ARF mimics the renal failure due to clinical administration of respective drugs; uranium, potassium dichromate-induced ARF mimics the occupational hazard; S-(1,2-dichlorovinyl)-L-cysteine-induced ARF simulate contaminated water-induced renal dysfunction; sepsis-induced ARF mimics the infection-induced renal failure and radiocontrast-induced ARF mimics renal failure in patients during use of radiocontrast media at the time of cardiac catheterization. Since each animal model has been created with specific methodology, therefore, it is essential to describe the model in detail and consequently interpret the results in the context of a specific model.

Myocardial and Renal Ischemia/Reperfusion Injury and Experimental Models: Review

“…107 Hücre zedelenmesinin selüler ve moleküler ayrıntılı mekanizmaları ve ardından gelişen yeniden yapılanma tam olarak bilinmemesine karşın, önceki çalışmalar renal epitelyal hücrelerin İ/R zedelenmesinin korteks ve medulla arasındaki çizgiye lokalize, nekroz ya da apoptoz yoluyla tübüler epitelyal hücrelerin ölümü ile ilişkili ve iskemik durumun şiddetine bağlı olduğunu göstermiştir. 108 1960'lı yıllardan itibaren iskemik ARY için birçok hayvan modeli geliştirilmiş ve test edilmiş-tir. Günümüzde ise başlıca iki farklı sıcak renal İ/R modeli kullanılmaktadır: 1) Çift taraflı (bilateral) renal İ/R ve 2) Tek taraflı (unilateral) renal İ/R.…”

“…ise, 45 dk iskeminin ardından 24 saat reperfüzyonun, insanlardaki hemodinamik değişimler ile indüklenen renal işlevleri taklit eden, daha uygun ve yaygın kullanılan hayvan modeli olduğunu ileri sürmüşlerdir. 108 …”

The first histopathological evidence of trimetazidine for the prevention of contrast-induced nephropathy

“…10 On d 6 of the experiment, 24-h urine and serum samples were again collected. 11 Final blood samples were collected from the tail vein under ether anesthesia.…”

The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

“…In a study conducted as a review reported that a lot of methods have been used to induce renal failure in rats that include IP administration of gentamicin sulfate at a dose of 100 mg/kg/day for 5-8 days (34). A number of drugs or chemicals have been used to prevent aminoglycoside-induced renal injury (6,21,33).…”