Animal models for assessing impact of C-section delivery on biological systems

Mode of delivery alters sensitivity to thermal and chemical stimuli in adult rats: An experimental study

“…It reinforces the hypothesis that exposure to different levels of endogenous stressors during vaginal or C-section delivery may be reflected by a long-term effect on hypothalamus-pituitary axis function. It may alter emotional behaviors and stress responsiveness.Cesarean deliveries have been associated with many changes in the physiology and behavior of the offspring(22). Interestingly recent data findings show sex-dependent differences in C-section offspring mice(23).c-Fos, is a specific marker of neuronal activity that is expressed in nociceptive pathways rapidly after noxious stimuli.…”