A gut (microbiome) feeling about addiction: Interactions with stress and social systems

García-Cabrerizo, Rubén; Cryan, John F.

doi:10.1016/j.ynstr.2024.100629

Cited by 2 publications

(2 citation statements)

References 258 publications

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“…With approximately 300 million people using illicit drugs, and nearly 40 million people affected by substance use disorders (SUDs), resulting in over 600,000 deaths annually worldwide, the challenge for public health and economic burden is staggering [67]. The challenge is exacerbated by the fact that there is a high relapse rate of 50 to 70%, despite the advances in our understanding of the neurobiological substrates and availability of newer treatment modalities [68]. Thus, the urgent need for more effective therapies.…”

Section: Drug Addictionmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

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Section: Drug Addictionmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…With approximately 300 million people using illicit drugs, and nearly 40 million people affected by SUD, resulting in over 600,000 deaths annually worldwide, the challenge for public health and the economic burden is staggering [79]. This challenge is exacerbated by the fact that there is a high relapse rate of 50 to 70% despite the advances in our understanding of the neurobiological substrates and availability of newer treatment modalities [80]. Thus, there is an urgent need for more effective therapies.…”

Section: Drug Addictionmentioning

confidence: 99%

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.

show abstract

A gut (microbiome) feeling about addiction: Interactions with stress and social systems

Cited by 2 publications

References 258 publications

Role of Glial Cells in Depression and Drug Addiction

Role of Glial Cells in Depression and Drug Addiction

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

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