Animal energy budgets affect the kinetics of xenobiotics

Kooijman, S.A.L.M.; Haren, R.J.F. van

doi:10.1016/0045-6535(90)90035-r

Cited by 28 publications

(21 citation statements)

References 24 publications

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“…From [521]. for PCB153 in aquatic organisms in the field, as given in [521]. Data from Oliver and Niimi [664,676] and from the Dutch Ministry of Public Works and Transport.…”

Section: Bioconcentration Coefficientmentioning

confidence: 99%

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Dynamic Energy and Mass Budgets in Biological Systems

Kooijman

2000

793

1,202

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second editionDynamic Energy Budget theory unifies the commonalities between organisms as prescribed by the implications of energetics, which link different levels of biological organization (cells, organisms and populations). The theory presents simple mechanistic rules that describe the uptake and use of energy and nutrients and the consequences for physiological organization throughout an organism's life cycle, including the relationships between energetics and aging and the effects of toxicants. In this new edition, the theory is broadened to encompass the fluxes of both energy and mass. All living organisms are now covered in a single quantitative framework, the predictions of which are tested against a wide variety of experimental results at the various levels of biological organization. The theory explains many general observations, such as the body size scaling relationships of certain physiological traits, and provides a theoretical basis for the widely used method of indirect calorimetry. In each case, the theory is developed in elementary mathematical terms, but a more detailed discussion of the methodological aspects of mathematical modelling is also included, making the book suitable for biologists and mathematicians with a broad interest in both fundamental and applied quantitative problems in biology.Bas Kooijman is Professor of Applied Theoretical Biology at the Vrije Universiteit in Amsterdam and is also head of the University's Department of Theoretical Biology. His research focuses on mathematical biology, in particular ecotoxicology which provided the framework for the original version of his Dynamic Energy Budget theory published in 1993 (Dynamic Energy Budgets in Biological Systems -Theory and Applications in Ecotoxicology). From the first edition:"This book is an excellent scientific product that informs and forces contemplation of issues relating to population and community ecology. The author has made a complex subject coherent." Thomas G. Hallam, Bulletin of Mathematical Biology "... a very useful and general tool to select more ecologically sound process equations and parameters in ecological models." Sven Erik Jørgensen, Ecological Modelling "The author has made a significant contribution to the problem of modelling the dynamics of biological populations at the level of the individual by synthesizing this very complicated subject into a relatively short list of general assumptions and putting the energetics of sub-models for vital rates on a solid basis." Jim Cushing, Mathematical Biosciences "The family of idealized models offered in this book is capable of playing a role analogous to that of Lotka-Volterra models in population dynamics ... I am confident that any model(s) capable of occupying this niche will be strongly influenced by the ideas in this book." Roger Nisbet, Ecology 9 LIVING TOGETHER Interaction between organisms: The spectrum from competition to preypredator systems. Evaluation of the consequences of the DEB model for population dynamics, food chains, and communities....

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“…From [521]. for PCB153 in aquatic organisms in the field, as given in [521]. Data from Oliver and Niimi [664,676] and from the Dutch Ministry of Public Works and Transport.…”

Section: Bioconcentration Coefficientmentioning

confidence: 99%

“…The least-squares-fitted curves are the cubic spline function for concentrations in the water and the model-based expectation for the concentration in the wet weight. From [521]. for PCB153 in aquatic organisms in the field, as given in [521].…”

Section: Bioconcentration Coefficientmentioning

confidence: 99%

Dynamic Energy and Mass Budgets in Biological Systems

Kooijman

2000

793

1,202

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“…We consider that this model provides a correct quantitative characterization of the baseline metabolism of (control) zebrafish. The model can be extended with a one compartment toxico-kinetics module (Kooijman and van Haren, 1990) which specifies the dynamics of the internal concentration, expressed in [M Q ] (nmol U cm −3 ), which then gets treated as a state variable. In line with deb theory we assume three ranges of [M Q ] for all compounds: too little, enough and too much.…”

Section: Introductionmentioning

confidence: 99%

Effects of uranium on the metabolism of zebrafish, Danio rerio

et al. 2012

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The increasing demand for nuclear energy results in heightened levels of uranium (U) in aquatic systems which present a potential health hazard to resident organisms. The aim of this study was to mechanistically assess how chronic exposure to environmentally relevant concentrations of U perturbs the complex interplay between feeding, growth, maintenance, maturation and reproduction throughout the life-cycle of an individual. To this end we analysed literature-based and original zebrafish toxicity data within a same mass and energy balancing conceptual framework. U was found to increase somatic maintenance leading to inhibition of spawning as well as increase hazard rate and costs for growth during the early life stages. The fish's initial conditions and elimination through reproduction greatly affected toxico-kinetics and effects. We demonstrate that growth and reproduction should be measured on specific individuals since mean values were hardly interpretable. The mean food level differed between experiments, conditions and individuals. This last 'detail' contributed substantially to the observed variability by its combined effect on metabolism, toxic effects and toxico-kinetics. The significance of this work is that we address exactly how these issues are related and derive conclusions which are independent of experimental protocol and coherent with a very large body of literature on zebrafish eco-physiology.

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“…Outputs of DEB models -energy utilization in each of the compartments and the transfer of energy between them -can be readily used as inputs to pharmacokinetic models to investigate the interactions between energy and toxicant intake (e.g. Kooijman and van Haren 1990, Nisbet et al 1996.…”

Section: Introductionmentioning

confidence: 99%

“…They can guide experimental research and reduce the necessary amounts of data. Two types of models are often used for this purpose: pharmacokinetic models (Boon et al 1994, Hickie et al 1999, Emond et al 2005) that determine distribution of the toxicant throughout the body, and energy budget models that determine energy intake and utilization and, because energy and toxicants are connected, help drive the pharmacokinetic models (Kooijman and van Haren 1990 2). Models of toxicant action connect the distribution of the toxicant to the effects on individuals.…”

Section: Introductionmentioning

confidence: 99%

Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations

Klanjšček¹

2006

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Animal energy budgets affect the kinetics of xenobiotics

Cited by 28 publications

References 24 publications

Dynamic Energy and Mass Budgets in Biological Systems

Dynamic Energy and Mass Budgets in Biological Systems

Effects of uranium on the metabolism of zebrafish, Danio rerio

Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations

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