Anhydrous Uric Acid: Nature and Occurrence of a New Form in Urinary Calculi

Shirley, Robin; Sutor, D. June

doi:10.1126/science.159.3814.544

Cited by 19 publications

(7 citation statements)

References 3 publications

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“…It is possible that in the stones, the TPEF signal of the small crystallites is not distinguished from the strong TPEF signal of the surrounding major constituents. The shape of the structures is also consistent with the usual monoclinic, pseudo‐orthorhombic shapes of uric acid crystallites . We also measured multimodal images of synthetic uric acid dihydrate [refer to Fig.…”

Section: Resultssupporting

confidence: 74%

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Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Pučetaitė

Tamošaitytė

Galli

et al. 2016

J Raman Spectroscopy

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Tracing aetiology and pathogenesis of urinary stone disease is of great importance in order to prescribe appropriate treatment and prevent recurrences. For this purpose, morphological examination combined with determination of chemical composition of urinary stones is fundamental. In this work, we have evaluated the potential of multimodal nonlinear optical imaging for investigation of (micro)structure and chemical composition of human urinary stones. The method provides high‐resolution multimodal images of the cross‐sectioned stones without any labelling or some other pretreatment of the samples. We have shown that various constituents of urinary stones can be well discriminated in the multimodal images according to their optical signals. In addition, small structures (1–5 µm in size) were observed in the cross‐sections of urinary stones of various types. These structures were identified as crystallites of uric acid. They could either act as an active element during formation of urinary stones or, more probably, be accidentally incorporated into their structure, as it is suggested by random distribution of the crystallites. The results of this work show that multimodal nonlinear optical imaging can provide relevant information about growth processes of urinary stones and deliver useful insights in aetiology and pathogenesis of urolithiasis. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Resultssupporting

confidence: 74%

“…The shape of the structures is also consistent with the usual monoclinic, pseudoorthorhombic shapes of uric acid crystallites. [44] We also measured multimodal images of synthetic uric acid dihydrate [refer to Fig. S4 (Supporting Information)]a possible uric acid hydration state in urinary stones.…”

Section: Resultsmentioning

confidence: 99%

Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Pučetaitė

Tamošaitytė

Galli

et al. 2016

J Raman Spectroscopy

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“…This a monoclinic pseudorhombic (I) and a monoclinic (II) unstable form. 35,36 Uric acid stones are charagrees with previous studies of Dosch 41 that concluded that the cation-stabilized uric acid dihyacterized by a high degree of mineralization and by a conchoidal structure consisting of characterdrate is not a pure compound but contains variable quantities of different cations. istic radii, comparable with that of whewellite.…”

Section: W0cmentioning

confidence: 64%

“…96 34 Infrared spectroscopy allows the identification of all these calculi drate and uric acid II on a stone surface has suggested 35 the probability of uric acid II being components.…”

Section: W0cmentioning

confidence: 99%

Infrared and Raman spectroscopy of urinary calculi: A review

1997

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The application of infrared and Raman spectroscopic techniques to the analysis of urinary calculi is reviewed and their relative efficiency and adaptability to routine analysis are discussed. Using the classification of urinary calculi based on their main constituents, infrared and Raman spectra of calcium oxalates, phosphates, uric acid, urates, and cystine are reported. Some characteristic bands are suggested as useful for analytical purposes. References to other constituents such as drugs are included. Although this review is aimed principally at human stones, it also extends to literature references dealing with urinary calculi from canine, feline, and equine animal species. © 1997 John Wiley & Sons, Inc. Biospectroscopy 3: 331–346, 1997

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“…Anhydrous and dihydrate uric acids are often found as constituents of urinary calculi, frequently associated with other materials (calcium oxalates, calcium phosphates, urates, etc.). Moreover, at least two crystalline forms (a monoclinic (i) pseudorhombic and a monoclinic (ii) unstable form) of anhydrous uric acid have been found in urinary stones 1 …”

Section: Introductionmentioning

confidence: 99%

Urates in uric acid renal calculi

et al. 2009

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Objectives:To investigate the presence of calcium urate, sodium, potassium and calcium in 'pure' uric acid calculi. Methods: Ten spontaneously passed uric acid urinary calculi have been examined by stereoscopic microscopy, infrared spectroscopy, scanning electron microscopy and energy dispersive X-Ray analysis. Results: The analysis of selected uric acid calculi revealed the presence of a near-pure calcium urate in two cases and of calcium enriched urate zones in all of the samples. Furthermore, in some cases complex urates containing sodium, potassium and calcium in different proportions appeared on the surface of the uric acid calculi studied , potassium being generally predominant. Ammonium urate was not detected. Conclusions: Most urinary uric acid calculi are not pure in composition. 'Complex urates', sodium, potassium and calcium were found together in various proportions in many areas of uric acid stones.

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Anhydrous Uric Acid: Nature and Occurrence of a New Form in Urinary Calculi

Cited by 19 publications

References 3 publications

Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Microstructure of urinary stones as studied by means of multimodal nonlinear optical imaging

Infrared and Raman spectroscopy of urinary calculi: A review

Urates in uric acid renal calculi

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