Urates in uric acid renal calculi

Bellanato, J.; Cifuentes, José-Luis Rodríguez-Miñón; Salvador, Esperanza; Medina, J. A.

doi:10.1111/j.1442-2042.2008.02244.x

Cited by 12 publications

(13 citation statements)

References 13 publications

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“…We acknowledge that not all of the crystals we have found may be MSU monohydrate. Urates aside from MSU, including calcium urate, potassium urate and magnesium urate, are known to form within the urinary tract leading to renal calculi47 48 and could be contributing to this other type of crystal seen in renal tophi and other tissues as well. Additionally, urate is a well-known chelator of metal ions such as zinc, copper and iron, and may form salts of metallourate complexes 49 50.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of birefringent crystals in cardiac and prostatic tissues, an observational study

et al. 2014

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IntroductionThe prevalence of urate crystals in residual tissue samples from coronary arteries, aortic valves and prostate glands was assessed.MethodsAlcohol-fixed coronary arteries from 55 explanted hearts, alcohol-fixed aortic valves collected from 75 valve replacement surgeries and 40 frozen, unfixed prostate specimens resected during cancer surgery were examined for birefringent crystals with polarising microscopy.ResultsIn the 55 explanted hearts, 6 (10.9%) contained a coronary artery with birefringent crystals. One of the 75 aortic valves (1.4%) contained negatively and positively birefringent crystals. Nineteen of the 40 (47.5%) prostates contained birefringent crystals.ConclusionsWe found that a remarkable percentage of coronary arteries and prostate specimens contained birefringent crystals. Crystal presence is an obvious prerequisite for possible crystal induced-inflammation in these tissues, just as similar crystals elicit a gouty inflammatory cascade in synovial joints. Further studies are necessary to determine whether urate crystals may play this role in these tissues and, if so, to establish whether urate-lowering therapy may be beneficial in prostatitis and coronary disease.

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Section: Discussionmentioning

confidence: 99%

Prevalence of birefringent crystals in cardiac and prostatic tissues, an observational study

et al. 2014

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“…6 Most urinary uric acid calculi are not pure in composition and complex urates, sodium, potassium, and calcium have been found together in various proportions. 7 An analysis of stones in gout patients in Japan showed that the incidence of common calcium salt stones was over 60%, while that of uric acid stones was only 30%. 8 This implies that the disruption of uric acid metabolism promotes not only uric acid stones, but also calcium salt stones.…”

Section: Introductionmentioning

confidence: 99%

Nephrolithiasis among male patients with newly diagnosed gout

Wan

Liu

et al. 2016

Hong Kong Med J

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“…In recent years more publications concerning the composition of kidney stones have been published. These publications address the causes of kidney stone disease and its relationship with metabolic syndrome [1,[7][8][9][10][11][12]. Nevertheless, the data concerning the relationship of metabolic syndrome and type of kidney stone remain contradictory.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome in Patients with Uric Acid and Calcium–based Kidney Stones

Hendrixson¹,

Malyško²,

Maţeikienė³

et al. 2014

JAMR

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The aim of the study was to investigate the prevalence of metabolic syndrome in patients with uric acid and calcium-based kidney stones and to investigate the relationship between metabolic syndrome and type of kidney stone using infrared spectroscopy to evaluate the chemical composition of kidney stones Sixty patients with urolithiasis were examined. Metabolic syndrome was diagnosed according to clinical and laboratory criteria. Weight, height, body mass index, waist circumference, and blood pressure of patients were measured. Blood tests were performed. Concentrations of total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, glucose and uric acid in blood, were analyzed. The kidney stones of patients were removed and the composition of each kidney stone was analyzed using Fourier transform infrared spectroscopy. Metabolic syndrome was diagnosed in 55% of the patients; 86.7% of patients with uric acid (UA) kidney stones and 44.4% of patients with calcium (Ca) based stones had metabolic syndrome. All patients diagnosed with metabolic syndrome were overweight or obese. Even though there were no statistically significant differences observed concerning the anthropometrical measures and arterial blood pressure (BP) between the UA stone formers and Ca-based stone formers, the results show a trend that failed to reach significance: higher waist size, BMI and arterial BP means in the group of patients with UA stones than in the patients with Ca-based stones. No statistically significant differences in lipid profile between the groups were found. Concentration of UA in blood serum was significantly higher in patients with UA kidney stones than it was in patients with Ca-based kidney stones. Significant positive correlation between triglycerides and serum UA concentrations, as well as body mass index and serum UA concentration, and negative correlation between concentrations of high-density lipoprotein cholesterol and UA was found. Conclusion: Metabolic syndrome was more prevalent in patients with uric acid stones than in the patients with calcium-based kidney stones, even though this relationship was not statistically significant, most likely because of the limited number of patients investigated.

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Urates in uric acid renal calculi

Cited by 12 publications

References 13 publications

Prevalence of birefringent crystals in cardiac and prostatic tissues, an observational study

Prevalence of birefringent crystals in cardiac and prostatic tissues, an observational study

Nephrolithiasis among male patients with newly diagnosed gout

Prevalence of Metabolic Syndrome in Patients with Uric Acid and Calcium–based Kidney Stones

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