Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder

Young, Christina B.; Chen, T.; Nusslock, Robin; Keller, Jennifer; Schatzberg, Alan F.; Menon, Vinod

doi:10.1038/tp.2016.80

Cited by 85 publications

(52 citation statements)

References 88 publications

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“…This is in line with previous findings that implicate these areas in the receipt of abstract rewards, like money (Kringelbach & Rolls, ; Sescousse et al, ). The OFC/vmPFC may represent the subjective value of a received reward (Bartra et al, ; Diekhof et al, ; Haber & Knutson, ; Levy & Glimcher, ; Peters & Büchel, ) and the subcallosal cortex may represent the subjective experience of pleasure (Anderson et al, ), especially as its dysfunction is linked to anhedonia (Hamani et al, ; Young et al, ). While the OFC and vmPFC are often presented as synonymous in function (Levy & Glimcher, ; Rushworth et al, ), they may have dissociable roles.…”

Section: Discussionmentioning

confidence: 99%

The anticipation and outcome phases of reward and loss processing: A neuroimaging meta‐analysis of the monetary incentive delay task

Oldham

Murawski

Fornito

et al. 2018

Human Brain Mapping

340

374

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The processing of rewards and losses are crucial to everyday functioning. Considerable interest has been attached to investigating the anticipation and outcome phases of reward and loss processing, but results to date have been inconsistent. It is unclear if anticipation and outcome of a reward or loss recruit similar or distinct brain regions. In particular, while the striatum has widely been found to be active when anticipating a reward, whether it activates in response to the anticipation of losses as well remains ambiguous. Furthermore, concerning the orbitofrontal/ventromedial prefrontal regions, activation is often observed during reward receipt. However, it is unclear if this area is active during reward anticipation as well. We ran an Activation Likelihood Estimation meta‐analysis of 50 fMRI studies, which used the Monetary Incentive Delay Task (MIDT), to identify which brain regions are implicated in the anticipation of rewards, anticipation of losses, and the receipt of reward. Anticipating rewards and losses recruits overlapping areas including the striatum, insula, amygdala and thalamus, suggesting that a generalised neural system initiates motivational processes independent of valence. The orbitofrontal/ventromedial prefrontal regions were recruited only during the reward outcome, likely representing the value of the reward received. Our findings help to clarify the neural substrates of the different phases of reward and loss processing, and advance neurobiological models of these processes.

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Section: Discussionmentioning

confidence: 99%

The anticipation and outcome phases of reward and loss processing: A neuroimaging meta‐analysis of the monetary incentive delay task

Oldham

Murawski

Fornito

et al. 2018

Human Brain Mapping

340

374

View full text Add to dashboard Cite

show abstract

“…Resveratrol increased levels of 5-HT, norepinephrine, and dopamine in various brain regions associated with depression, which coincides with the monoamine hypothesis [ 88 ]. Depression is associated with low levels of dopamine, and irregularities in dopaminergic neurons that play a large role in reward and motivation may be responsible for the anhedonia exhibited by depressed patients [ 89 ]. Based on the large body of research that has implicated these monoamines in depression, resveratrol may decrease depressive behaviors in animals by increasing neurotransmitter levels.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms

2018

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Depression is currently treated by pharmacotherapies that can elicit debilitating side effects for patients. Novel treatment options with limited side effects are currently being researched. Resveratrol is a polyphenol and phytoalexin found in the skins of grapes, red wine, Japanese knotweed, and peanuts. It has been studied extensively for its antioxidant and anti-inflammatory properties. Resveratrol has also gained attention for its neuroprotective properties. The aim of the review was to examine the mechanisms by which resveratrol reduces depressive behaviors in animal models. In total, 22 studies met the established criteria for final review. Behavioral aspects of depression were investigated using validated measures such as the forced swimming test, tail suspension test, sucrose preference test, and open field test. While many physical measures were taken, three main biological mechanisms were explored: Regulation of the hypothalamic–pituitary–adrenal axis; decreased inflammation; and increased Brain-Derived Neurotrophic Factor and neurogenesis. Based on these findings, resveratrol may be deemed an effective treatment for depression in animal models at doses between 10–80 mg/kg/day, although higher doses had the most significant effects. Future studies should examine the effects of resveratrol on depression in humans to determine the eligibility of resveratrol as a natural antidepressant with less severe side effects.

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“…Connectivity disruptions in the lateral PFC have, moreover, been associated with depressive symptoms, like anhedonia and distress (Young et al, 2016), supporting the assumption that better emotional stability supports the ability to work on a task unhindered by negative emotions (compare Perkins et al (2015)).…”

Section: /32mentioning

confidence: 75%

Modulations in resting state networks of subcortical structures linked to creativity

et al. 2019

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Creativity is a sine qua non ability for almost all aspects of everyday life. Although very profound behavioural models were provided by 21th century psychologists, the neural correlates of these personality features associated with creativity are largely unknown. Recent models suggest strong relationships between dopamine release and various creative skills. Herein, we employed functional connectivity analyses of resting-state functional magnetic imaging data in order to shed light on these neural underpinnings of creative aspects. For improved sensitivity, we performed the study at ultra-high magnetic field (7 Tesla). Seed regions were defined based on subcortical (ventral tegmental area/substantia nigra, nucleus caudatus) activation foci of a remote associates task (RAT). In addition, bilateral PCC was used as seed region to examine the default-mode network. Network strength across subjects was regressed against a battery of psychological variables related to creativity. Dopaminergic network variations turned out to be indicative for individual differences in creative traits. In this regard, the caudate network showed stronger connectivity in individuals with higher extraversion measures, while connectivity with the midbrain network was found increased with higher ideational behaviour and emotional stability.

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Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder

Cited by 85 publications

References 88 publications

The anticipation and outcome phases of reward and loss processing: A neuroimaging meta‐analysis of the monetary incentive delay task

The anticipation and outcome phases of reward and loss processing: A neuroimaging meta‐analysis of the monetary incentive delay task

Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms

Modulations in resting state networks of subcortical structures linked to creativity

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