Anguibactin‐ versus vanchrobactin‐mediated iron uptake in <i>Vibrio anguillarum</i>: evolution and ecology of a fish pathogen

Lemos, Manuel L.; Balado, Miguel; Osorio, Carlos R.

doi:10.1111/j.1758-2229.2009.00103.x

Cited by 25 publications

(21 citation statements)

References 52 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An example of a phase variable system in fish pathogens is the production of bacterial siderophore for iron acquisition during infection events. Some pathogenic marine bacteria, e.g., Vibrio anguillarum, Yersinia ruckeri , and Aeromonas salmonicida subspecies salmonicida , are known for their production of siderophore to increase their virulence (Fernández et al, 2007; Lemos et al, 2009; Najimi, 2011). In Vibrio harveyi , phase variation also involve a switch from a luminous to a non-luminous strain.…”

Section: Eco-physiology Of Microbe-microbe and Host-microbe Interactimentioning

confidence: 99%

Managing the Microbial Community of Marine Fish Larvae: A Holistic Perspective for Larviculture

et al. 2018

View full text Add to dashboard Cite

The availability of high-quality juveniles is a bottleneck in the farming of many marine fish species. Detrimental larvae-microbe interactions are a main reason for poor viability and quality in larval rearing. In this review, we explore the microbial community of fish larvae from an ecological and eco-physiological perspective, with the aim to develop the knowledge basis for microbial management. The larvae are exposed to a huge number of microbes from external and internal sources in intensive aquaculture, but their relative importance depend on the rearing technology used (especially flow-through vs. recirculating systems) and the retention time of the water in the fish tanks. Generally, focus has been on microbes entering the system, but microbes from growth within the system is normally a substantial part of the microbes encountered by larvae. Culture independent methods have revealed an unexpected high richness of bacterial species associated with larvae, with 100–250 operational taxonomic units associated with one individual. The microbiota of larvae changes rapidly until metamorphosis, most likely due to changes in the selection pressure in the digestive tract caused by changes in host-microbe and microbe-microbe interactions. Even though the microbiota of larvae is distinctly different from the microbiota of the water and the live food, the microbiota of the water strongly affects the microbiota of the larvae. We are in the early phase of understanding larvae-microbe interactions in vivo, but some studies with other animals than fish emphasize that we so far have underestimated the complexity of these interactions. We present examples demonstrating the diversity of these interactions. A large variety of microbial management methods exist, focusing on non-selective reduction of microbes, selective enhancement of microbes, and on improvement of the resistance of larvae against microbes. However, relatively few methods have been studied extensively. We believe that there is a lot to gain by increasing the diversity of approaches for microbial management. As many microbial management methods are perturbations of the microbial community, we argue that ecological theory is needed to foresee and test for longer term consequences in microbe-microbe and microbe-larvae interactions. We finally make some recommendations for future research and development.

show abstract

Section: Eco-physiology Of Microbe-microbe and Host-microbe Interactimentioning

confidence: 99%

Managing the Microbial Community of Marine Fish Larvae: A Holistic Perspective for Larviculture

et al. 2018

View full text Add to dashboard Cite

show abstract

“…) and the genes responsible for vanchrobactin synthesis are present in all V. anguillarum strains suggesting that the vanchrobactin iron‐uptake system is ancestral to the anguibactin‐based system which was likely acquired later via horizontal gene transfer (Lemos et al . ). Evidence suggests that V. harveyi is the likely ancestor of the anguibactin‐based iron‐uptake system which is present in V. anguillarum , although the transition could have also been the reverse (Naka et al .…”

Section: Pathology and Virulencementioning

confidence: 99%

A comprehensive review of Vibrio (Listonella) anguillarum: ecology, pathology and prevention

Hickey

Lee

2017

Reviews in Aquaculture

View full text Add to dashboard Cite

Vibrio (Listonella) anguillarum is a marine bacteria that is pathogenic to a number of aquatic organisms including several species which are important to the aquaculture industry. Organisms that are infected by V. anguillarum are diagnosed with vibriosis which can be lethal in a matter of days. Vibriosis can be particularly devastating to aquaculture businesses and measures of prevention or treatment are generally quite expensive. Efforts to understand and control V. anguillarum virulence have been of high‐priority among international aquatic research studies. The knowledge that has accumulated as a result of this collective research effort is reviewed in this article.

show abstract

“…The problem becomes particularly intriguing in instances where a molecular system seems disused. This is apparently the case for siderophore-based iron acquisition systems, where so-called 'secondary' siderophores are usually expressed only weakly or not at all under iron limitation [4,6,7]. An evolutionary consequence of this disuse should be that selection eliminates superfluous systems [8].…”

Section: Introductionmentioning

confidence: 99%

Switching between apparently redundant iron-uptake mechanisms benefits bacteria in changeable environments

2013

View full text Add to dashboard Cite

Bacteria often possess multiple siderophore-based iron uptake systems for scavenging this vital resource from their environment. However, some siderophores seem redundant, because they have limited iron-binding efficiency and are seldom expressed under iron limitation. Here, we investigate the conundrum of why selection does not eliminate this apparent redundancy. We focus on Pseudomonas aeruginosa, a bacterium that can produce two siderophores-the highly efficient but metabolically expensive pyoverdine, and the inefficient but metabolically cheap pyochelin. We found that the bacteria possess molecular mechanisms to phenotypically switch from mainly producing pyoverdine under severe iron limitation to mainly producing pyochelin when iron is only moderately limited. We further show that strains exclusively producing pyochelin grew significantly better than strains exclusively producing pyoverdine under moderate iron limitation, whereas the inverse was seen under severe iron limitation. This suggests that pyochelin is not redundant, but that switching between siderophore strategies might be beneficial to trade off efficiencies versus costs of siderophores. Indeed, simulations parameterized from our data confirmed that strains retaining the capacity to switch between siderophores significantly outcompeted strains defective for one or the other siderophore under fluctuating iron availabilities. Finally, we discuss how siderophore switching can be viewed as a form of collective decision-making, whereby a coordinated shift in behaviour at the group level emerges as a result of positive and negative feedback loops operating among individuals at the local scale.

show abstract

Anguibactin‐ versus vanchrobactin‐mediated iron uptake in Vibrio anguillarum: evolution and ecology of a fish pathogen

Cited by 25 publications

References 52 publications

Managing the Microbial Community of Marine Fish Larvae: A Holistic Perspective for Larviculture

Managing the Microbial Community of Marine Fish Larvae: A Holistic Perspective for Larviculture

A comprehensive review of Vibrio (Listonella) anguillarum: ecology, pathology and prevention

Switching between apparently redundant iron-uptake mechanisms benefits bacteria in changeable environments

Contact Info

Product

Resources

About