Angle-Resolved Low Coherence Interferometry for Detection of Dysplasia in Barrett's Esophagus

Wax, Adam; Terry, Neil G.; Dellon, Evan S.; Shaheen, Nicholas J.

doi:10.1053/j.gastro.2011.06.020

Cited by 34 publications

(26 citation statements)

References 28 publications

(31 reference statements)

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“…a/LCI collects scattered light over a range of angles near the backscattering direction, which is analyzed to determine nuclear size and optical density, a significant biomarker of dysplasia. A substantial body of work has shown the effectiveness of a/LCI for precancer detection in the cervix [2, 3], esophagus [4, 5], and colon [6]. While these studies have demonstrated high diagnostic accuracy, the inability to scan large areas of tissue without mechanical displacement of the probe has been a limiting factor in clinical application.…”

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confidence: 99%

Scanning system for angle-resolved low-coherence interferometry

Steelman

Chu

et al. 2017

Opt. Lett.

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Angle-resolved low-coherence interferometry (a/LCI) detects precancer by enabling depth-resolved measurements of nuclear morphology in vivo. A significant limitation of a/LCI is the point-probe nature of the method, sampling <0.5 mm2 before probe relocation is necessary. In this work, we demonstrate a scanning method capable of assessing an area >100 mm2 without repositioning. By utilizing a reflection-only three-optic rotator (ROTOR) prism and two-axis scanning mirror, we demonstrate radial scans of a sample with a linear range of 12 mm and a full rotational range of 180°. Use of this design will improve the diagnostic utility of a/LCI for wide-area screening of tissue health.

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confidence: 99%

Scanning system for angle-resolved low-coherence interferometry

Steelman

Chu

et al. 2017

Opt. Lett.

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“…The sensitivity of this method is 69% and specificity 85%. 67 Nuclear magnetic resonance spectroscopy uses the magnetic properties of certain atomic nuclei to determine the physical and chemical properties of atoms or the molecules in which they are contained. This technique has been used to identify metabolic signatures of oral squamous cell carcinoma compared with normal tissues.…”

Section: J Dermatol Case Rep 2015 4 Pp 89-97mentioning

confidence: 99%

Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

Warszawik-Hendzel

Olszewska

Maj

et al. 2015

J Dermatol Case Rep

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Squamous cell carcinoma is the second most common cutaneous malignancy after basal cell carcinoma. Although the gold standard of diagnosis for squamous cell carcinoma is biopsy followed by histopathology evaluation, optical non-invasive diagnostic tools have obtained increased attention. Dermoscopy has become one of the basic diagnostic methods in clinical practice. The most common dermoscopic features of squamous cell carcinoma include clustered vascular pattern, glomerular vessels and hyperkeratosis. Under reflectance confocal microscopy, squamous cell carcinoma shows an atypical honeycomb or disarranged pattern of the spinous-granular layer of the epidermis, round nucleated bright cells in the epidermis and round vessels in the dermis. High frequency ultrasound and optical coherence tomography may be helpful in predominantly in pre-surgical evaluation of tumor size. Emerging non-invasive or minimal invasive techniques with possible application in the diagnosis of squamous cell carcinoma of the skin, lip, oral mucosa, vulva or other tissues include high-definition optical coherence tomography, in vivo multiphoton tomography, direct oral microscopy, electrical impedance spectroscopy, fluorescence spectroscopy, Raman spectroscopy, elastic scattering spectroscopy, differential path-length spectroscopy, nuclear magnetic resonance spectroscopy, and angle-resolved low coherence interferometry. (J Dermatol Case Rep. 2015; 9(4): 89-97)

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“…Techniques such as optical coherence tomography (OCT) [1–3] and angle-resolved low-coherence interferometry (a/LCI) [4–6] rely on the precise delivery and collection of single-mode illumination to image biological tissues, providing information on epithelial substructure [7,8] and nuclear morphology [9]. Typically, single-mode fibers are used to transmit coherent light, with high throughput and rejection of all but the fundamental mode.…”

Section: Introductionmentioning

confidence: 99%

Comparison of imaging fiber bundles for coherence-domain imaging

et al. 2018

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Use of imaging fiber bundles for coherence-domain imaging has remained limited to date. In this work, we provide characterization of commercially available imaging bundles for coherence-domain imaging, by evaluating their modal structure for applicability to interferometric imaging. We further examine custom fabricated bundles developed in collaboration with a corporate partner for their ability to reduce interelement optical path length variability and cross talk between elements. The results presented here will serve as a useful guide for comparing fiber bundles for coherence imaging while also offering an improved understanding of the functionality and limitations of ismaging bundles for advancing coherent imaging technologies.

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Angle-Resolved Low Coherence Interferometry for Detection of Dysplasia in Barrett's Esophagus

Cited by 34 publications

References 28 publications

Scanning system for angle-resolved low-coherence interferometry

Scanning system for angle-resolved low-coherence interferometry

Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

Comparison of imaging fiber bundles for coherence-domain imaging

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