Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

Warszawik-Hendzel, Olga; Olszewska, Małgorzata; Maj, Małgorzata; Rakowska, Adriana; Czuwara, Joanna; Rudnicka, Lidia

doi:10.3315/jdcr.2015.1221

Cited by 60 publications

(47 citation statements)

References 71 publications

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“…Dermoscopy, reflectance confocal microscopy and optical coherence tomography are being used as diagnostic tools prior to surgery 3 . However, all of these optical devices have limited detection depth (<1 mm) 2 .…”

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confidence: 99%

Photoacoustic and Fluorescence Imaging of Cutaneous Squamous Cell Carcinoma in Living Subjects Using a Probe Targeting Integrin αvβ6

Zhang

Hong

et al. 2017

Sci Rep

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Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer worldwide. Today, cSCC is diagnosed by visual inspection followed by invasive skin biopsy. There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection. Photoacoustic imaging (PAI) possesses high ultrasonic resolution and strong optical contrast at new depths (<1–5 cm). Together with exogenous contrast agents, PAI has found promising use in various tumors in living subjects. The expression of integrin αvβ6 is significantly up-regulated in cSCC. We fabricated an anti-integrin αvβ6 antibody and labeled it with indocyanine green (ICG) to form an ICG-αvβ6 antibody. The results showed that the ICG-αvβ6 antibody probe could be used to detect cSCC with high specificity (3-fold over the control by PAI) and deep penetration (approximately 1 cm) by PAI. This suggests that the ICG-αvβ6 antibody is a promising probe targeting the integrin αvβ6 for detection of cSCC tumors by PAI and fluorescence imaging. It may find clinical application in the early diagnosis of cSCC as well as in intraoperative navigation.

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confidence: 99%

Photoacoustic and Fluorescence Imaging of Cutaneous Squamous Cell Carcinoma in Living Subjects Using a Probe Targeting Integrin αvβ6

Zhang

Hong

et al. 2017

Sci Rep

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“…In fact, in case of completely ulcerated BCCs lacking specific dermoscopic criteria, and presenting vascular patterns traditionally associated with melanoma and/or SCC (Fig. 5) (16,17), the clinician simply lacks the means to correctly identify a BCC, and is driven towards an incorrect diagnosis of melanoma or SCC. This results in overdiagnosis of SCC/melanoma and in more urgent and radical surgical removal; this, of course, does not pose any particular concern to the patient management (except perhaps increased patient psychological stress and unnecessary increased burden of urgent surgical removals), as the lesion will be ultimately excised.…”

Section: Discussionmentioning

confidence: 99%

Vascular Patterns in Cutaneous Ulcerated Basal Cell Carcinoma: A Retrospective Blinded Study Including Dermoscopy

Arpaia¹,

Filoni²,

Bonamonte³

et al. 2017

Acta Derm Venerol

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The aim of this retrospective study was to determine the type and prevalence of vascular patterns in the ulcerated and non-ulcerated portions of histologically proven basal cell carcinomas (BCCs) and correlate them with other dermoscopic and clinical features, including the clinically supposed diagnosis. Three authors retrospectively collected 156 clinical and 156 dermoscopic digital images of ulcerated BCCs (histologically confirmed); each image was blindly evaluated by 2 other authors, who did not know the histological diagnosis. Seventeen lesions were completely ulcerated, while 139 lesions presented ulcerated and non-ulcerated portions. Correct clinical diagnosis was associated with the type of lesion, in particular 90.6% of partially ulcerated lesions were correctly diagnosed with clinical-dermoscopic examination, compared with 11.8% of totally ulcerated lesions (χ2 = 64.00, p = 0.000). Presence of arborizing pattern in the ulcerated portion was associated with a correct diagnosis (Fisher's exact test, p = 0.015). Correct diagnosis was also associated with absence of dotted pattern in the non-ulcerated area (χ2 = 16.18, p = 0.000); the absence of hairpin (χ2 = 6.08, p = 0.000) and glomerular patterns were associated with correct diagnosis in the ulcerated areas (χ2 = 18.64, p = 0.000). In case of completely ulcerated BCC the clinician lacks the means to correctly identify the correct nature of the lesion, and is driven towards an incorrect diagnostic conclusion.

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“…In these cases of uncertain diagnosis, dermoscopy is a very useful method with high sensitivity and specificity (98.7% and 95%, respectively) for the diagnosis of AK. 7 …”

Section: Introductionmentioning

confidence: 99%

Clinical utility of ingenol mebutate in the management of actinic keratosis: perspectives from clinical practice

Skroza¹,

Bernardini²,

Proietti³

et al. 2018

TCRM

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Actinic keratoses (AKs) are epidermal cutaneous neoplasia observed predominantly in middle-aged and older subjects with mainly photo type I and photo type II on sun-exposed surfaces as a result of DNA damage. AKs have historically been characterized as being “precancerous”; however, now it is considered by many authors a carcinoma in situ that can persist or progress to invasive squamous cell carcinoma (SCC) with metastatic potential. Despite the advances in the recognition of typical clinic, dermoscopic and histologic patterns, currently it is not yet possible to predict which AKs will progress to SCC. For this reason, early diagnosis and effective therapy are recommended based on cost/risk/benefit analysis. Current treatment consists of lesion-directed or field-directed therapies or a combination of both. Among the topical field therapies, ingenol mebutate stands out for its therapeutic efficacy, both as directed lesion therapy and as field directed therapy. The aim of this review is to demonstrate the utility of ingenol mebutate in the management of AK in daily clinical practice and to highlight data from real world in order to confirm evidence from pivotal studies. In order to explore clinical data from real world, PubMed searches were performed with the search terms “clinical data ingenol mebutate” and “real world ingenol mebutate”. The hits were examined for relevant articles using defaults criteria. The timeframe for the sample search started from the first publication on this topic in 2008 up to now. A total of 23 articles were found using the keywords specified above. The overview points out a low number of real-life studies on the effectiveness and tolerability of this novel treatment due to short period of clinical experience for its recent approval. Further real-life studies are required in order to better identify the efficacy, safety and adherence of the drug on a larger population.

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Non-invasive diagnostic techniques in the diagnosis of squamous cell carcinoma

Cited by 60 publications

References 71 publications

Photoacoustic and Fluorescence Imaging of Cutaneous Squamous Cell Carcinoma in Living Subjects Using a Probe Targeting Integrin αvβ6

Photoacoustic and Fluorescence Imaging of Cutaneous Squamous Cell Carcinoma in Living Subjects Using a Probe Targeting Integrin αvβ6

Vascular Patterns in Cutaneous Ulcerated Basal Cell Carcinoma: A Retrospective Blinded Study Including Dermoscopy

Clinical utility of ingenol mebutate in the management of actinic keratosis: perspectives from clinical practice

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